High-throughput biochemical profiling reveals functional adaptation of a bacterial Argonaute

Argonautes are nucleic acid-guided proteins that perform numerous cellular functions across all domains of life. Little is known about how distinct evolutionary pressures have shaped each Argonaute's biophysical properties. We applied high-throughput biochemistry to characterize how Thermus the...

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Bibliographic Details
Published in:	Molecular cell Vol. 82; no. 7; p. 1329
Main Authors:	Ober-Reynolds, Benjamin, Becker, Winston R, Jouravleva, Karina, Jolly, Samson M, Zamore, Phillip D, Greenleaf, William J
Format:	Journal Article
Language:	English
Published:	United States 07.04.2022
Subjects:	Argonaute Proteins - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism DNA - genetics Endonucleases - metabolism Thermus thermophilus - genetics Thermus thermophilus single-molecule biophysics siDNA Argonaute miRNA high-throughput biochemistry pAGO siRNA RNA silencing TtAgo
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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