A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Despite key roles in sister chromatid cohesion and chromosome organization, the mechanism by which cohesin rings are loaded onto DNA is still unknown. Here we combine biochemical approaches and cryoelectron microscopy (cryo-EM) to visualize a cohesin loading intermediate in which DNA is locked betwe...

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Veröffentlicht in:	Molecular cell Jg. 79; H. 6; S. 917
Hauptverfasser:	Higashi, Torahiko L, Eickhoff, Patrik, Sousa, Joana S, Locke, Julia, Nans, Andrea, Flynn, Helen R, Snijders, Ambrosius P, Papageorgiou, George, O'Reilly, Nicola, Chen, Zhuo A, O'Reilly, Francis J, Rappsilber, Juri, Costa, Alessandro, Uhlmann, Frank
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.09.2020
Schlagworte:	Adenosine Triphosphatases - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - ultrastructure Chromatids - genetics Chromatids - ultrastructure Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - ultrastructure Chromosome Segregation - genetics Cohesins Cryoelectron Microscopy DNA - genetics DNA - ultrastructure Nucleic Acid Conformation Protein Conformation Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - ultrastructure Sister Chromatid Exchange - genetics ABC-ATPase cohesin SMC complexes chromosome segregation sister chromatid cohesion S. pombe DNA-protein crosslink mass spectrometry Mis4/Scc2/NIPBL DNA loop extrusion cryo-electron microscopy
ISSN:	1097-4164, 1097-4164
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