Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome

Degradation of the endothelial glycocalyx, a glycosaminoglycan (GAG)-rich layer lining the vascular lumen, is associated with the onset of kidney injury in animal models of critical illness. It is unclear if similar pathogenic degradation occurs in critically ill patients. To determine if urinary in...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 194; no. 4; pp. 439 - 449
Main Authors:	Schmidt, Eric P., Overdier, Katherine H., Sun, Xiaojun, Lin, Lei, Liu, Xinyue, Yang, Yimu, Ammons, Lee Anne, Hiller, Terra D., Suflita, Matt A., Yu, Yanlei, Chen, Yin, Zhang, Fuming, Cothren Burlew, Clay, Edelstein, Charles L., Douglas, Ivor S., Linhardt, Robert J.
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 15.08.2016
Subjects:	Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Acute Kidney Injury - mortality Acute Kidney Injury - urine Biomarkers - urine Case-Control Studies Colorado Glycosaminoglycans - urine Hospital Mortality Humans Intensive Care Units - statistics & numerical data Mass Spectrometry - methods Original Predictive Value of Tests Prognosis Prospective Studies Shock, Septic - complications Shock, Septic - diagnosis Shock, Septic - mortality Shock, Septic - urine Trauma Severity Indices Wounds and Injuries - classification Wounds and Injuries - surgery Wounds and Injuries - urine glycocalyx heparan sulfate glycomics chondroitin sulfate hyaluronic acid
ISSN:	1073-449X, 1535-4970, 1535-4970
Online Access:	Get full text
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