Molecular nature and physiological role of the mitochondrial calcium uniporter channel

Calcium (Ca ) signaling is critical for cell function and cell survival. Mitochondria play a major role in regulating the intracellular Ca concentration ([Ca ] ). Mitochondrial Ca uptake is an important determinant of cell fate and governs respiration, mitophagy/autophagy, and the mitochondrial path...

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Bibliographic Details
Published in:	American Journal of Physiology: Cell Physiology Vol. 320; no. 4; p. C465
Main Authors:	Alevriadou, B Rita, Patel, Akshar, Noble, Megan, Ghosh, Sagnika, Gohil, Vishal M, Stathopulos, Peter B, Madesh, Muniswamy
Format:	Journal Article
Language:	English
Published:	United States 01.04.2021
Subjects:	Animals Apoptosis Calcium Channels - chemistry Calcium Channels - drug effects Calcium Channels - genetics Calcium Channels - metabolism Calcium Signaling - drug effects Cardiovascular Diseases - drug therapy Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Energy Metabolism - drug effects Gene Expression Regulation Humans Membrane Potential, Mitochondrial Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial Diseases - drug therapy Mitochondrial Diseases - genetics Mitochondrial Diseases - metabolism Mitochondrial Diseases - pathology Molecular Targeted Therapy Muscular Diseases - drug therapy Muscular Diseases - genetics Muscular Diseases - metabolism Muscular Diseases - pathology Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Protein Conformation Reactive Oxygen Species - metabolism Structure-Activity Relationship mitochondrial energetics calcium signaling reactive oxygen species mitochondrial calcium uptake
ISSN:	1522-1563, 1522-1563
Online Access:	Get more information
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