Hybrids of Ixodes ricinus and Ixodes persulcatus ticks effectively acquire and transmit tick-borne encephalitis virus

Ixodes rici nus and Ixodes persulcatus ticks are the main vectors of tick-borne encephalitis virus (TBEV), which has three main subtypes connected with certain tick species: the European subtype, associated with I. ricinus , and the Siberian and Far-Eastern subtypes, associated with I. persulcatus ....

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Vydáno v:Frontiers in cellular and infection microbiology Ročník 13; s. 1104484
Hlavní autoři: Belova, Oxana A., Polienko, Alexandra E., Averianova, Anastasia D., Karganova, Galina G.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media SA 20.01.2023
Frontiers Media S.A
Témata:
Animals
Arachnid Vectors
Arachnids
Cellular and Infection Microbiology
Encephalitis
Encephalitis Viruses, Tick-Borne - genetics
Encephalitis, Tick-Borne - epidemiology
Epidemiology
Female
Geographical distribution
Hybridization
Hybrids
Ixodes - genetics
Ixodes persulcatus
Ixodes ricinus
Laboratories
Male
Mice
Molting
Sympatric populations
Sympatry
Tick-borne encephalitis
tick-borne encephalitis virus
trans-stadial transmission
vector
Vectors
Viral infections
Viruses
West Nile virus
Europe
Russia
vector
Ixodes ricinus
hybrids
trans-stadial transmission
Ixodes persulcatus
tick-borne encephalitis virus
ISSN:2235-2988, 2235-2988
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Shrnutí:Ixodes rici nus and Ixodes persulcatus ticks are the main vectors of tick-borne encephalitis virus (TBEV), which has three main subtypes connected with certain tick species: the European subtype, associated with I. ricinus , and the Siberian and Far-Eastern subtypes, associated with I. persulcatus . Distribution ranges of these species overlap and form large sympatric areas in the East European Plain and Baltic countries. It has previously been shown that crossing of I. ricinus and I. persulcatus is possible, with the appearance of sterile hybrids. Hybridization of ticks can affect not only the spread of ticks but also the properties of natural foci of arbovirus infections, in particular TBEV. In the present study, we analyzed the effectiveness of virus transmission from infected mice to larvae and nymphs and trans-stadial transmission (from larvae to nymph and adult) in I. ricinus , I. persulcatus , and hybrids. For this purpose, we bred a hybrid generation from the crossing of I. persulcatus females and I. ricinus males, and we used the Siberian and European subtypes of TBEV. We showed that after feeding on infected mice, virus prevalence in engorged ticks decreased over time, and after molting, the opposite was true. In hybrids we observed the highest acquisition effectiveness and RNA copy numbers during Siberian TBEV subtype transmission. The efficiency of trans-stadial transmission of both TBEV subtypes was similar in hybrids and parental species. After the second trans-stadial TBEV transmission, a significant increase in ticks’ infection rates was observed only in specific subtype-tick combination. Our data demonstrate the possible features of TBEV circulation in the I. ricinus and I. persulcatus sympatry area.
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Reviewed by: Sara Moutailler, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (ANSES), France; Vaclav Honig, Academy of Sciences of the Czech Republic (ASCR), Czechia
Edited by: Ryan Oliver Marino Rego, Academy of Sciences of the Czech Republic (ASCR), Czechia
This article was submitted to Virus and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2023.1104484