Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties

In addition to an anticoagulant activity, activated protein C (APC) also exhibits anti-inflammatory and cytoprotective properties. These properties may contribute to the beneficial effect of APC in treating severe sepsis patients. A higher incidence of bleeding because of its anticoagulant function...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 282; no. 12; p. 9251
Main Authors:	Bae, Jong-Sup, Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R
Format:	Journal Article
Language:	English
Published:	United States 23.03.2007
Subjects:	Anti-Inflammatory Agents - pharmacology Anticoagulants - chemistry Anticoagulants - metabolism Apoptosis Calcium - chemistry Cell Line, Transformed Cell Movement Disulfides Humans Mutation Protein Binding Protein C - chemistry Protein Structure, Secondary Protein Structure, Tertiary Signal Transduction Thrombomodulin - chemistry
ISSN:	0021-9258
Online Access:	Get more information
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