Mitochondrial calcium cycling in neuronal function and neurodegeneration
Mitochondria are essential for proper cellular function through their critical roles in ATP synthesis, reactive oxygen species production, calcium (Ca 2+ ) buffering, and apoptotic signaling. In neurons, Ca 2+ buffering is particularly important as it helps to shape Ca 2+ signals and to regulate num...
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| Vydané v: | Frontiers in cell and developmental biology Ročník 11; s. 1094356 |
|---|---|
| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Switzerland
Frontiers Media SA
24.01.2023
Frontiers Media S.A |
| Predmet: | |
| ISSN: | 2296-634X, 2296-634X |
| On-line prístup: | Získať plný text |
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| Shrnutí: | Mitochondria are essential for proper cellular function through their critical roles in ATP synthesis, reactive oxygen species production, calcium (Ca
2+
) buffering, and apoptotic signaling. In neurons, Ca
2+
buffering is particularly important as it helps to shape Ca
2+
signals and to regulate numerous Ca
2+
-dependent functions including neuronal excitability, synaptic transmission, gene expression, and neuronal toxicity. Over the past decade, identification of the mitochondrial Ca
2+
uniporter (MCU) and other molecular components of mitochondrial Ca
2+
transport has provided insight into the roles that mitochondrial Ca
2+
regulation plays in neuronal function in health and disease. In this review, we discuss the many roles of mitochondrial Ca
2+
uptake and release mechanisms in normal neuronal function and highlight new insights into the Ca
2+
-dependent mechanisms that drive mitochondrial dysfunction in neurologic diseases including epilepsy, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. We also consider how targeting Ca
2+
uptake and release mechanisms could facilitate the development of novel therapeutic strategies for neurological diseases. |
|---|---|
| Bibliografia: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Reviewed by: Cecilia Hidalgo, University of Chile, Chile Edited by: Karthik Babu Mallilankaraman, National University of Singapore, Singapore Evgeny V. Pavlov, New York University, United States This article was submitted to Molecular and Cellular Pathology, a section of the journal Frontiers in Cell and Developmental Biology |
| ISSN: | 2296-634X 2296-634X |
| DOI: | 10.3389/fcell.2023.1094356 |