Regulation of transcription and chromatin structure by pRB: Here, there and everywhere

Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step...

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Vydáno v:Cell cycle (Georgetown, Tex.) Ročník 11; číslo 17; s. 3189 - 3198
Hlavní autoři: Talluri, Srikanth, Dick, Frederick A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Taylor & Francis 01.09.2012
Landes Bioscience
Témata:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
cell cycle
Cell Cycle Checkpoints - genetics
Cell Cycle Checkpoints - physiology
Cellular Senescence - physiology
chromatin
Chromatin Assembly and Disassembly - physiology
condensin
Cycle
differentiation
E2F
Gene Expression Regulation - physiology
Genes, cdc - physiology
Landes
Models, Biological
Organogenesis
Promoter Regions, Genetic - physiology
Proteins
retinoblastoma
Retinoblastoma Protein - metabolism
Retinoblastoma Protein - physiology
Review
senescence
Signal Transduction - physiology
transcription
Transcription, Genetic - physiology
ISSN:1538-4101, 1551-4005, 1551-4005
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Shrnutí:Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step in cell cycle regulation. The Retinoblastoma (RB) tumor suppressor pathway regulates this decision-making step. Since being the subject of Knudson's 'two hit hypothesis', there has been considerable interest in understanding pRB's role in cancer. It is best known for repressing E2F dependent transcription of cell cycle genes. However, pRB's role in controlling chromatin structure is expanding and bringing it into new regulatory paradigms. In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains.
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ISSN:1538-4101
1551-4005
1551-4005
DOI:10.4161/cc.21263