Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan

In Karachi, Pakistan, a South Asian megacity with a high prevalence of tuberculosis (TB) and low HIV prevalence, we assessed the effectiveness of fluoroquinolone-based preventive therapy for drug-resistant (DR) TB exposure. During February 2016–March 2017, high-risk household contacts of DR TB patie...

Full description

Saved in:

Bibliographic Details
Published in:	Emerging infectious diseases Vol. 27; no. 3; pp. 805 - 812
Main Authors:	Malik, Amyn A., Gandhi, Neel R., Lash, Timothy L., Cranmer, Lisa M., Omer, Saad B., Ahmed, Junaid F., Siddiqui, Sara, Amanullah, Farhana, Khan, Aamir J., Keshavjee, Salmaan, Hussain, Hamidah, Becerra, Mercedes C.
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01.03.2021 Centers for Disease Control and Prevention
Subjects:	Age Antibiotics Antitubercular Agents - therapeutic use CME contact investigation Diabetes Disease prevention Dosage and administration Drug resistance drug-resistant tuberculosis infection Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan fluoroquinolone Households Humans latent infection Malnutrition Medicine, Preventive Megacities Methods Mycobacterium tuberculosis Pakistan Patients Prevention Preventive health services preventive therapy prophylaxis Quinolone antibacterial agents Quinolones Risk factors Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Pakistan Micronesia Karachi Pakistan Karachi Pakistan bacteria antimicrobial resistance fluoroquinolone preventive therapy contact investigation drug-resistant tuberculosis infection tuberculosis and other mycobacteria latent infection prophylaxis
ISSN:	1080-6040, 1080-6059, 1080-6059
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	In Karachi, Pakistan, a South Asian megacity with a high prevalence of tuberculosis (TB) and low HIV prevalence, we assessed the effectiveness of fluoroquinolone-based preventive therapy for drug-resistant (DR) TB exposure. During February 2016–March 2017, high-risk household contacts of DR TB patients began a 6-month course of preventive therapy with a fluoroquinolone-based, 2-drug regimen. We assessed effectiveness in this cohort by comparing the rate and risk for TB disease over 2 years to the rates and risks reported in the literature. Of 172 participants, TB occurred in 2 persons over 336 person-years of observation. TB disease incidence rate observed in the cohort was 6.0/1,000 person-years. The incidence rate ratio ranged from 0.29 (95% CI 0.04–1.3) to 0.50 (95% CI 0.06–2.8), with a pooled estimate of 0.35 (95% CI 0.14–0.87). Overall, fluoroquinolone-based preventive therapy for DR TB exposure reduced risk for TB disease by 65%.
AbstractList	In Karachi, Pakistan, a South Asian megacity with a high prevalence of tuberculosis (TB) and low HIV prevalence, we assessed the effectiveness of fluoroquinolone-based preventive therapy for drug-resistant (DR) TB exposure. During February 2016–March 2017, high-risk household contacts of DR TB patients began a 6-month course of preventive therapy with a fluoroquinolone-based, 2-drug regimen. We assessed effectiveness in this cohort by comparing the rate and risk for TB disease over 2 years to the rates and risks reported in the literature. Of 172 participants, TB occurred in 2 persons over 336 person-years of observation. TB disease incidence rate observed in the cohort was 6.0/1,000 person-years. The incidence rate ratio ranged from 0.29 (95% CI 0.04–1.3) to 0.50 (95% CI 0.06–2.8), with a pooled estimate of 0.35 (95% CI 0.14–0.87). Overall, fluoroquinolone-based preventive therapy for DR TB exposure reduced risk for TB disease by 65%. Fluoroquinolone-based preventive therapy reduced risk for tuberculosis disease by 65%. In Karachi, Pakistan, a South Asian megacity with a high prevalence of tuberculosis (TB) and low HIV prevalence, we assessed the effectiveness of fluoroquinolone-based preventive therapy for drug-resistant (DR) TB exposure. During February 2016–March 2017, high-risk household contacts of DR TB patients began a 6-month course of preventive therapy with a fluoroquinolone-based, 2-drug regimen. We assessed effectiveness in this cohort by comparing the rate and risk for TB disease over 2 years to the rates and risks reported in the literature. Of 172 participants, TB occurred in 2 persons over 336 person-years of observation. TB disease incidence rate observed in the cohort was 6.0/1,000 person-years. The incidence rate ratio ranged from 0.29 (95% CI 0.04–1.3) to 0.50 (95% CI 0.06–2.8), with a pooled estimate of 0.35 (95% CI 0.14–0.87). Overall, fluoroquinolone-based preventive therapy for DR TB exposure reduced risk for TB disease by 65%.
Audience	Professional Academic
Author	Keshavjee, Salmaan Amanullah, Farhana Omer, Saad B. Khan, Aamir J. Malik, Amyn A. Becerra, Mercedes C. Hussain, Hamidah Gandhi, Neel R. Lash, Timothy L. Cranmer, Lisa M. Ahmed, Junaid F. Siddiqui, Sara
Author_xml	– sequence: 1 givenname: Amyn A. surname: Malik fullname: Malik, Amyn A. – sequence: 2 givenname: Neel R. surname: Gandhi fullname: Gandhi, Neel R. – sequence: 3 givenname: Timothy L. surname: Lash fullname: Lash, Timothy L. – sequence: 4 givenname: Lisa M. surname: Cranmer fullname: Cranmer, Lisa M. – sequence: 5 givenname: Saad B. surname: Omer fullname: Omer, Saad B. – sequence: 6 givenname: Junaid F. surname: Ahmed fullname: Ahmed, Junaid F. – sequence: 7 givenname: Sara surname: Siddiqui fullname: Siddiqui, Sara – sequence: 8 givenname: Farhana surname: Amanullah fullname: Amanullah, Farhana – sequence: 9 givenname: Aamir J. surname: Khan fullname: Khan, Aamir J. – sequence: 10 givenname: Salmaan surname: Keshavjee fullname: Keshavjee, Salmaan – sequence: 11 givenname: Hamidah surname: Hussain fullname: Hussain, Hamidah – sequence: 12 givenname: Mercedes C. surname: Becerra fullname: Becerra, Mercedes C.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33624580$$D View this record in MEDLINE/PubMed
BookMark	eNp1kk1vEzEQhleoiH7AlSOyhIQ4dIO_1mtfKlUl0IpKRCicLa89mzhs1qm9W9F_j9OEiFbiZHv8zPt6xnNaHPWhh6J4S_CEUUw-gXe0xmxCMVNEvChOCJa4FLhSR4c9x8fFaUorjElOUa-KY8YE5ZXEJ8XdtG3BDv4eekgJhRbNIuTDNoLmS4hm84DaENEMYgp9QtPfm5DAITOg67AGNAT0OY6L8gcknwbTD2g-NhDt2IUcOEffTDR26c_RzPx6BF4XL1vTJXizX8-Kn1-m86vr8vb715ury9vSciVEKSmIXFTTCCY5YcxYozjFsgJeyxo7wrghwBpGQFauaaWy0DhmGXGyVQ1hZ8XNTtcFs9Kb6NcmPuhgvH4MhLjQJg7edqCpBCydrYirMXeEGm6V4TKbO66yQ9a62GltxmYNzub-RNM9EX160_ulXoR7XSuKRb0V-LgXiOFuhDTotU8Wus70EMakKVcM4yrbZ_T9M3QVxtjnVmlaYaVyVwTO1IcdtTC5gCWYblim0I2Dz5-kL0UlBMudoxl89-_TD2_-OwIZmOwAG0NKEdoDQrDezpjez5jezVhO4M8SrB_M1jiX7rv_pf0BufDUIg
CitedBy_id	crossref_primary_10_3390_pathogens11101189 crossref_primary_10_1093_cid_ciae024 crossref_primary_10_3390_tropicalmed7120418 crossref_primary_10_1093_cid_ciaf069 crossref_primary_10_1016_j_cmi_2023_09_015 crossref_primary_10_1093_ofid_ofad087 crossref_primary_10_25100_cm_v56i1_5918 crossref_primary_10_1016_j_heliyon_2024_e30942 crossref_primary_10_7759_cureus_25454 crossref_primary_10_1016_S2213_2600_23_00084_X crossref_primary_10_3390_pathogens12050728 crossref_primary_10_2147_IDR_S531874 crossref_primary_10_1016_S1473_3099_25_00157_4 crossref_primary_10_1056_NEJMoa2314318 crossref_primary_10_3390_tropicalmed8020089
Cites_doi	10.1093/cid/ciz438 10.1016/S1473-3099(17)30447-4 10.1183/13993003.02414-2019 10.1183/13993003.01179-2015 10.1093/cid/cix208 10.1201/9781351249980-21 10.1097/INF.0b013e3181783aca 10.1093/cid/ciaa613 10.1371/journal.pone.0215322 10.1164/rccm.201406-1159OC 10.5588/ijtld.13.0028 10.1093/cid/cit655 10.1542/peds.109.5.765 10.1093/cid/cit643 10.1183/13993003.00224-2020 10.1183/09031936.00070812 10.1136/bmj.l5894 10.1093/cid/ciz502 10.1183/09031936.00205512 10.3201/eid2103.141313 10.1093/cid/ciaa327 10.1097/INF.0b013e31826f6063 10.5588/ijtld.13.0593 10.1016/S0140-6736(10)61972-1 10.1097/INF.0000000000000260
ContentType	Journal Article
Copyright	COPYRIGHT 2021 U.S. National Center for Infectious Diseases Published 2021. This article is a U.S. Government work and is in the public domain in the USA.
Copyright_xml	– notice: COPYRIGHT 2021 U.S. National Center for Infectious Diseases – notice: Published 2021. This article is a U.S. Government work and is in the public domain in the USA.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7X7 7XB 8C1 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BENPR CCPQU FYUFA GHDGH K9- K9. KB0 M0R M0S NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 7X8 5PM DOA
DOI	10.3201/eid2703.203916
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Public Health Database ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) Consumer Health Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Consumer Health Database ProQuest Health & Medical Collection Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Family Health (Alumni Edition) ProQuest Central ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection ProQuest Central (New) ProQuest Public Health ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest One Academic Middle East (New)
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Public Health
DocumentTitleAlternate	Preventive Therapy for Drug-Resistant TB
EISSN	1080-6059
EndPage	812
ExternalDocumentID	oai_doaj_org_article_28e08dc51d704d12a4c9a483bbd49b31 PMC7920671 A656636382 33624580 10_3201_eid2703_203916
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GeographicLocations	Pakistan Micronesia Karachi Pakistan
GeographicLocations_xml	– name: Pakistan – name: Karachi Pakistan – name: Micronesia
GrantInformation_xml	– fundername: NIAID NIH HHS grantid: P30 AI050409 – fundername: NCATS NIH HHS grantid: UL1 TR001863 – fundername: NIAID NIH HHS grantid: K23 AI143479 – fundername: NIAID NIH HHS grantid: K24 AI114444 – fundername: NIAID NIH HHS grantid: U19 AI111211
GroupedDBID	--- -~X .GJ 186 29G 2WC 36B 53G 5GY 5VS 6PF 7RV 7X7 85S 8C1 8FI 8FJ 9K5 A8Z AAWTL AAYXX ABDBF ABUWG ACGFO ACUHS ADBBV ADRAZ AEGXH AENEX AETEA AEUYN AFFHD AFKRA AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC B0M BAIFH BANNL BAWUL BBTPI BCNDV BENPR C1A CCPQU CITATION DIK DO4 E3Z EAD EAP EAS EBC EBD EBS EDH EJD EMB EMH EMI EMK EMOBN EPL EPT ESX F5P FRP FYUFA GROUPED_DOAJ GX1 HMCUK HYE IAO IBB IEA IEP IHR IHW IMI INH INR IOF IOV IPO ISR ITC K9- KQ8 M0R M48 NAPCQ NEJ O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PJZUB PPXIY PV9 Q.E QF4 QM9 QN7 QO4 Q~Q RGD RGQ RNS RPM RXW RZL SV3 TAE TR2 TUS TWZ UKHRP UQL W2D WH7 WOQ WOW XSB YRT YV5 YXF ZBA ZGI ~8M 0ZS AAYOK ACZ ALIPV CGR CUY CVF ECM EIF M~E NPM XJT 3V. 7XB 8FK K9. PKEHL PQEST PQQKQ PQUKI 7X8 ESTFP PUEGO 5PM
ID	FETCH-LOGICAL-c4966-82e6203bb6384133aca942085e47870d134a1e3b31e85dbf89cebd3c31d8f9b13
IEDL.DBID	BENPR
ISSN	1080-6040 1080-6059
IngestDate	Fri Oct 03 12:53:14 EDT 2025 Tue Nov 04 02:01:37 EST 2025 Fri Sep 05 06:07:05 EDT 2025 Sat Nov 29 14:53:14 EST 2025 Thu May 22 20:59:50 EDT 2025 Wed Feb 19 02:28:09 EST 2025 Tue Nov 18 22:34:26 EST 2025 Sat Nov 29 05:36:15 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	Karachi Pakistan bacteria antimicrobial resistance fluoroquinolone preventive therapy contact investigation drug-resistant tuberculosis infection tuberculosis and other mycobacteria latent infection prophylaxis
Language	English
License	This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c4966-82e6203bb6384133aca942085e47870d134a1e3b31e85dbf89cebd3c31d8f9b13
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://doaj.org/article/28e08dc51d704d12a4c9a483bbd49b31
PMID	33624580
PQID	2509962060
PQPubID	105375
PageCount	8
ParticipantIDs	doaj_primary_oai_doaj_org_article_28e08dc51d704d12a4c9a483bbd49b31 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7920671 proquest_miscellaneous_2493005704 proquest_journals_2509962060 gale_healthsolutions_A656636382 pubmed_primary_33624580 crossref_primary_10_3201_eid2703_203916 crossref_citationtrail_10_3201_eid2703_203916
PublicationCentury	2000
PublicationDate	2021-03-00 20210301 2021-03-01
PublicationDateYYYYMMDD	2021-03-01
PublicationDate_xml	– month: 03 year: 2021 text: 2021-03-00
PublicationDecade	2020
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: Atlanta
PublicationTitle	Emerging infectious diseases
PublicationTitleAlternate	Emerg Infect Dis
PublicationYear	2021
Publisher	U.S. National Center for Infectious Diseases Centers for Disease Control and Prevention
Publisher_xml	– name: U.S. National Center for Infectious Diseases – name: Centers for Disease Control and Prevention
References	Sloot (key-10.3201/eid2703.203916-202102222300-R-2-28) 2014; 190 Saunders (key-10.3201/eid2703.203916-202102222300-R-2-29) 2017; 17 key-10.3201/eid2703.203916-202102222300-R-2-6 Fox (key-10.3201/eid2703.203916-202102222300-R-2-22) 2013; 41 Seddon (key-10.3201/eid2703.203916-202102222300-R-2-15) 2013; 57 Feja (key-10.3201/eid2703.203916-202102222300-R-2-13) 2008; 27 Becerra (key-10.3201/eid2703.203916-202102222300-R-2-24) 2011; 377 Becerra (key-10.3201/eid2703.203916-202102222300-R-2-25) 2013; 32 Chiang (key-10.3201/eid2703.203916-202102222300-R-2-9) 2020 key-10.3201/eid2703.203916-202102222300-R-2-19 Matteelli (key-10.3201/eid2703.203916-202102222300-R-2-8) 2015; 46 key-10.3201/eid2703.203916-202102222300-R-2-16 Rodina (key-10.3201/eid2703.203916-202102222300-R-2-3) 2019; 54 Adler-Shohet (key-10.3201/eid2703.203916-202102222300-R-2-11) 2014; 33 Schaaf (key-10.3201/eid2703.203916-202102222300-R-2-14) 2002; 109 Malik (key-10.3201/eid2703.203916-202102222300-R-2-21) 2020 Gebreselassie (key-10.3201/eid2703.203916-202102222300-R-2-5) 2020; 55 key-10.3201/eid2703.203916-202102222300-R-2-10 Cegielski (key-10.3201/eid2703.203916-202102222300-R-2-2) 2020; 55 Malik (key-10.3201/eid2703.203916-202102222300-R-2-20) 2020; 70 Trieu (key-10.3201/eid2703.203916-202102222300-R-2-17) 2015; 21 Shah (key-10.3201/eid2703.203916-202102222300-R-2-7) 2014; 58 Amanullah (key-10.3201/eid2703.203916-202102222300-R-2-31) 2014; 18 Smieja (key-10.3201/eid2703.203916-202102222300-R-2-30) 2000; 1999 Martin-Sanchez (key-10.3201/eid2703.203916-202102222300-R-2-27) 2019; 14 Marks (key-10.3201/eid2703.203916-202102222300-R-2-18) 2017; 64 Bamrah (key-10.3201/eid2703.203916-202102222300-R-2-12) 2014; 18 Reichler (key-10.3201/eid2703.203916-202102222300-R-2-26) 2020; 70 Diel (key-10.3201/eid2703.203916-202102222300-R-2-4) 2013; 42 Becerra (key-10.3201/eid2703.203916-202102222300-R-2-23) 2019; 367 key-10.3201/eid2703.203916-202102222300-R-2-1
References_xml	– volume: 70 start-page: 1562 year: 2020 ident: key-10.3201/eid2703.203916-202102222300-R-2-26 article-title: Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team. Risk factors for tuberculosis and effect of preventive therapy among close contacts of persons with infectious tuberculosis. publication-title: Clin Infect Dis doi: 10.1093/cid/ciz438 – volume: 17 start-page: 1190 year: 2017 ident: key-10.3201/eid2703.203916-202102222300-R-2-29 article-title: A score to predict and stratify risk of tuberculosis in adult contacts of tuberculosis index cases: a prospective derivation and external validation cohort study. publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(17)30447-4 – volume: 55 start-page: 1902414 year: 2020 ident: key-10.3201/eid2703.203916-202102222300-R-2-5 article-title: The case for assessing the full value of new tuberculosis vaccines. publication-title: Eur Respir J doi: 10.1183/13993003.02414-2019 – volume: 46 start-page: 1838 year: 2015 ident: key-10.3201/eid2703.203916-202102222300-R-2-8 article-title: Numbers needed to treat to prevent tuberculosis. publication-title: Eur Respir J doi: 10.1183/13993003.01179-2015 – volume: 64 start-page: 1670 year: 2017 ident: key-10.3201/eid2703.203916-202102222300-R-2-18 article-title: Systematic review, meta-analysis, and cost-effectiveness of treatment of latent tuberculosis to reduce progression to multidrug-resistant tuberculosis. publication-title: Clin Infect Dis doi: 10.1093/cid/cix208 – ident: key-10.3201/eid2703.203916-202102222300-R-2-6 doi: 10.1201/9781351249980-21 – volume: 27 start-page: 907 year: 2008 ident: key-10.3201/eid2703.203916-202102222300-R-2-13 article-title: Management of pediatric multidrug-resistant tuberculosis and latent tuberculosis infections in New York City from 1995 to 2003. publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0b013e3181783aca – start-page: ciaa613 year: 2020 ident: key-10.3201/eid2703.203916-202102222300-R-2-9 article-title: Concordance of drug resistance profiles between persons with drug-resistant tuberculosis and their household contacts: a systematic review and meta-analysis. publication-title: Clin Infect Dis doi: 10.1093/cid/ciaa613 – volume: 14 start-page: e0215322 year: 2019 ident: key-10.3201/eid2703.203916-202102222300-R-2-27 article-title: Tuberculosis incidence among infected contacts detected through contact tracing of smear-positive patients. publication-title: PLoS One doi: 10.1371/journal.pone.0215322 – ident: key-10.3201/eid2703.203916-202102222300-R-2-19 – volume: 190 start-page: 1044 year: 2014 ident: key-10.3201/eid2703.203916-202102222300-R-2-28 article-title: Risk of tuberculosis after recent exposure. A 10-year follow-up study of contacts in Amsterdam. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201406-1159OC – volume: 18 start-page: 912 year: 2014 ident: key-10.3201/eid2703.203916-202102222300-R-2-12 article-title: Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009-2012. publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.13.0028 – volume: 57 start-page: 1676 year: 2013 ident: key-10.3201/eid2703.203916-202102222300-R-2-15 article-title: Preventive therapy for child contacts of multidrug-resistant tuberculosis: a prospective cohort study. publication-title: Clin Infect Dis doi: 10.1093/cid/cit655 – volume: 1999 start-page: CD001363 year: 2000 ident: key-10.3201/eid2703.203916-202102222300-R-2-30 article-title: Isoniazid for preventing tuberculosis in non-HIV infected persons. publication-title: Cochrane Database Syst Rev – volume: 109 start-page: 765 year: 2002 ident: key-10.3201/eid2703.203916-202102222300-R-2-14 article-title: Evaluation of young children in contact with adult multidrug-resistant pulmonary tuberculosis: a 30-month follow-up. publication-title: Pediatrics doi: 10.1542/peds.109.5.765 – ident: key-10.3201/eid2703.203916-202102222300-R-2-1 – volume: 58 start-page: 381 year: 2014 ident: key-10.3201/eid2703.203916-202102222300-R-2-7 article-title: Yield of contact investigations in households of patients with drug-resistant tuberculosis: systematic review and meta-analysis. publication-title: Clin Infect Dis doi: 10.1093/cid/cit643 – volume: 55 start-page: 2000224 year: 2020 ident: key-10.3201/eid2703.203916-202102222300-R-2-2 article-title: The continued hunt for the elusive standard short regimen for treatment of multidrug-resistant tuberculosis. publication-title: Eur Respir J doi: 10.1183/13993003.00224-2020 – volume: 41 start-page: 140 year: 2013 ident: key-10.3201/eid2703.203916-202102222300-R-2-22 article-title: Contact investigation for tuberculosis: a systematic review and meta-analysis. publication-title: Eur Respir J doi: 10.1183/09031936.00070812 – volume: 367 start-page: l5894 year: 2019 ident: key-10.3201/eid2703.203916-202102222300-R-2-23 article-title: Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. publication-title: BMJ doi: 10.1136/bmj.l5894 – volume: 70 start-page: 1958 year: 2020 ident: key-10.3201/eid2703.203916-202102222300-R-2-20 article-title: Tuberculosis preventive therapy for individuals exposed to drug-resistant tuberculosis: feasibility and safety of a community-based delivery of fluoroquinolone-containing preventive regimen. publication-title: Clin Infect Dis doi: 10.1093/cid/ciz502 – volume: 54 start-page: PA5278 year: 2019 ident: key-10.3201/eid2703.203916-202102222300-R-2-3 article-title: Adverse events in patients with MDR TB, treated by three types of the chemotherapy regimens. publication-title: Eur Respir J – volume: 42 start-page: 785 year: 2013 ident: key-10.3201/eid2703.203916-202102222300-R-2-4 article-title: Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination. publication-title: Eur Respir J doi: 10.1183/09031936.00205512 – ident: key-10.3201/eid2703.203916-202102222300-R-2-16 – volume: 21 start-page: 500 year: 2015 ident: key-10.3201/eid2703.203916-202102222300-R-2-17 article-title: Moxifloxacin Prophylaxis against MDR TB, New York, New York, USA. publication-title: Emerg Infect Dis doi: 10.3201/eid2103.141313 – start-page: ciaa327 year: 2020 ident: key-10.3201/eid2703.203916-202102222300-R-2-21 article-title: Risk factors for adverse events in household contacts prescribed preventive treatment for drug-resistant TB exposure. publication-title: Clin Infect Dis doi: 10.1093/cid/ciaa327 – ident: key-10.3201/eid2703.203916-202102222300-R-2-10 – volume: 32 start-page: 115 year: 2013 ident: key-10.3201/eid2703.203916-202102222300-R-2-25 article-title: Tuberculosis in children exposed at home to multidrug-resistant tuberculosis. publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0b013e31826f6063 – volume: 18 start-page: 520 year: 2014 ident: key-10.3201/eid2703.203916-202102222300-R-2-31 article-title: High tuberculosis prevalence in children exposed at home to drug-resistant tuberculosis. publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.13.0593 – volume: 377 start-page: 147 year: 2011 ident: key-10.3201/eid2703.203916-202102222300-R-2-24 article-title: Tuberculosis burden in households of patients with multidrug-resistant and extensively drug-resistant tuberculosis: a retrospective cohort study. publication-title: Lancet doi: 10.1016/S0140-6736(10)61972-1 – volume: 33 start-page: 664 year: 2014 ident: key-10.3201/eid2703.203916-202102222300-R-2-11 article-title: Management of latent tuberculosis infection in child contacts of multidrug-resistant tuberculosis. publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0000000000000260
SSID	ssj0012019
Score	2.477053
Snippet	In Karachi, Pakistan, a South Asian megacity with a high prevalence of tuberculosis (TB) and low HIV prevalence, we assessed the effectiveness of... Fluoroquinolone-based preventive therapy reduced risk for tuberculosis disease by 65%. In Karachi, Pakistan, a South Asian megacity with a high prevalence of...
SourceID	doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	805
SubjectTerms	Age Antibiotics Antitubercular Agents - therapeutic use CME contact investigation Diabetes Disease prevention Dosage and administration Drug resistance drug-resistant tuberculosis infection Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan fluoroquinolone Households Humans latent infection Malnutrition Medicine, Preventive Megacities Methods Mycobacterium tuberculosis Pakistan Patients Prevention Preventive health services preventive therapy prophylaxis Quinolone antibacterial agents Quinolones Risk factors Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1ba9VAEF6k-CCIWK_RqisIvjQ0e0myeazaIiilyBH6tuwt9kBJ2pOk-PM7k80JJ4j44utmc5tL5pvs7DeEfPBlabxhNoVQwFNpeZFWRuZpKQqHcLoWbuSZ_V6enamLi-p8p9UX1oRFeuAouCOuQqa8y5kvM-kZN9LBxZSw1svKjjuoOaCebTI1rR9AWKtiaT0kR2Cnka5RwPBRWHsOZg6pIe45XYSjkbX_z2_zTnBaFk7uRKLTx-TRBCHpcXz0fXIvNE_Iw_j_jcZtRU_JTaQlnr5ltK3plqzpNtBVpBKgAFjp-Qi5O3ry-7rtgqemp9g6nfYt_bIZfqU_QocQs-nparBh44arFgYO6Tcker5cH9IJgzbPyM_Tk9Xnr-nUXiF1EpKcVPFQgBCsBReEUCaMMxUutucBCXsyz4Q0LAiQcVC5t7WqXLBeOMG8qivLxHOy17RNeEmoFZm33mKuZyVTThXM13UheA2nCO4Tkm6lrN3EPY4tMK405CCoFT1pRUetJOTjPP86sm78deYnVNo8C9myxwGwIT3ZkP6XDSXkHapcx62ns8_rYwS7AsTDE3KwtQY9OXmnAT1CtsizIkvI-_kwuCeuuZgmtAPMkRU2BID7JuRFNJ75WQWAB5krOLtcmNXiZZZHmvXlSAFeVki7z179j7d_TR5wLNQZC-sOyF6_GcIbct_d9utu83b0qzvp5SV- priority: 102 providerName: Directory of Open Access Journals
Title	Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan
URI	https://www.ncbi.nlm.nih.gov/pubmed/33624580 https://www.proquest.com/docview/2509962060 https://www.proquest.com/docview/2493005704 https://pubmed.ncbi.nlm.nih.gov/PMC7920671 https://doaj.org/article/28e08dc51d704d12a4c9a483bbd49b31
Volume	27
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1080-6059 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0012019 issn: 1080-6040 databaseCode: DOA dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 1080-6059 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0012019 issn: 1080-6040 databaseCode: M0R dateStart: 20200101 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1080-6059 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0012019 issn: 1080-6040 databaseCode: 7X7 dateStart: 20200101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1080-6059 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0012019 issn: 1080-6040 databaseCode: 7RV dateStart: 20200101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1080-6059 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0012019 issn: 1080-6040 databaseCode: BENPR dateStart: 20200101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1080-6059 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0012019 issn: 1080-6040 databaseCode: 8C1 dateStart: 20200101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdYxwMSGt8QGMVISLwsWvzRxnlC2-iEBFRVVVDfovgjW6Up6Zp22p_PXeyGVQheePGDYyu53Pk-7PPvCPlg07SwBdMxmAIeS82HcVbIQZyKoUF3uhSmxZn9lo7Haj7PJmHDrQlplVud2CpqWxvcIz8GUw2uOU-GyafldYxVo_B0NZTQ2CP7iFQme2T_dDSeTLtzBDBvmU-xhyAJ5NXDNgroPnYLy0HcIUTEu6c7ZqlF7_9TR98xUrsJlHcs0vmj_6XlMTkIvig98cLzhNxz1VPy0G_kUX8_6Rm59vjGQSnSuqRb1KcbR2cek4CC50snre_e0NHtsm6cpcWaYg12uq7p59XmIp66Bn3Vak1nG-1WZnNVQ8cR_YqI0ZeLIxqc2eo5-XE-mp19iUOdhthIiJZixR0QI7SGtQw2URSmyPDUfuAQ-SexTMiCOaEFc2pgdaky47QVRjCrykwz8YL0qrpyrwjVIrHaagwatWTKqCGzZTkUvIQpgtuIxFs25SaAmGMtjascghlkax7Ymnu2RuRjN37p4Tv-OvIUud6NQtjttqNeXeRhFedcuURZM2A2TaRlvJAGJFsB6VZmQF9E3qHM5P4Oa6c88hP0mgX8Hh6Rw61I5EFbNPlveYjI--4xrHM8vCkqV29gjMywsgC8NyIvvfR13yrAC5EDBbPTHbncIWb3SbW4bLHE0wzx-9nrf3_WG_KAYy5Pm3t3SHrr1ca9JffNzXrRrPpkL53-xHaetq2CVp2xfliM_XafA9rvyfQXiyw6Xg
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGQAIJcWcLDGYkEC-LFttp4zwgNNimTS3VNBW0NxNfslWakq5pB_wpfiPnxElYheBtD7w6thMn37nFx98h5LVNksxmTIdgCngYa94P0yzuhYnoG3Snc2FqntlhMhrJk5P0aIX8bM_CYFplqxNrRW1Lg__It8FUg2vOo370fnoRYtUo3F1tS2h4WAzcj28QslXvDnfh-77hfH9v_PEgbKoKhCYG3z6U3ME0QmtAHmhwkZksxT3mnkOemsgyEWfMCS2Ykz2rc5kap60wglmZp5oJmPcGuQl6nGEKWXL8pdu1AGOa-oR-CMlAOjxJpIDmbTexHIQLAlI86bpkBOtaAX9ahCsmcTld84r927__v725B-Re42nTHS8aD8mKKx6Ru_43JfWnrx6TC8_e3Kh8Wua05bS6dHTsGRco-PX0qI5MKrr3fVpWztJsTrHCPJ2XdHe2OA2PXYWeeDGn44V2M7M4L6Fhiw6QD_tsskUbV714Qj5fy6qfktWiLNw6oVpEVluNIbGOmTSyz2ye9wXPYYjgNiBhCwtlGop2rBRyriBUQxipBkbKwyggb7v-U09O8teeHxBlXS8kFa8bytmpanSU4tJF0poes0kUW8az2IDcSli6jVNYX0A2EaPKn9DtVKPawZhAwOvhAdloIagaXVip3_gLyKvuMmgx3JrKClcuoE-cYt0EuG9A1jzau2cV4GPFPQmjkyU5WFrM8pViclYzpScpVidgz_79WJvk9sH401AND0eD5-QOx6ylOstwg6zOZwv3gtwyl_NJNXtZizslX69bSn4B7DmO9g
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGQAgJcb8EBjMSiJdFje20cR4QGusqpk5VhYa0Ny--ZKs0JV3TDvhr_DrOiZOwCsHbHnh1nMtJvnOLj79DyFubJJnNmA7BFfAw1nwQplncDxMxMBhO58LUPLOHyWQij4_T6Qb52e6FwbLK1ibWhtqWBv-R98BVQ2jOo0HUy5uyiOlw9HF-EWIHKVxpbdtpeIiM3Y9vkL5VHw6G8K3fcT7aP9r7HDYdBkITQ5wfSu7gkkJrQCFYc5GZLMX15r5DzprIMhFnzAktmJN9q3OZGqetMIJZmaeaCbjuDXITBBNYTib3uvISBo419cX9kJ6BpnjCSAHDPTezHBQNklPc9brmEOu-AX96hyvucb1084ovHN3_n9_iA3KvicDprleZh2TDFY_IXf_7kvpdWY_JhWd1blwBLXPacl1dOnrkmRgoxPt0WmcsFd3_Pi8rZ2m2pNh5ni5LOlysTsMvrsIIvVjSo5V2C7M6L2Fgh46RJ_tstkObEL54Qr5ei9RPyWZRFu45oVpEVluNqbKOmTRywGyeDwTP4RTBbUDCFiLKNNTt2EHkXEEKh5BSDaSUh1RA3nfz55605K8zPyHiullINl4PlItT1dguxaWLpDV9ZpMotoxnsQF9liC6jVOQLyDbiFfld-52JlPtYq6AqsEDstXCUTU2slK_sRiQN91hsG64ZJUVrlzBnDjFfgpw34A888jvnlVA7BX3JZydrOnEmjDrR4rZWc2gnqTYtYC9-PdjbZPboBzq8GAyfknucCxmqosPt8jmcrFyr8gtc7mcVYvXteZTcnLdSvILS8WXUQ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effectiveness+of+Preventive+Therapy+for+Persons+Exposed+at+Home+to+Drug-Resistant+Tuberculosis%2C+Karachi%2C+Pakistan&rft.jtitle=Emerging+infectious+diseases&rft.au=Malik%2C+Amyn+A&rft.au=Gandhi%2C+Neel+R&rft.au=Lash%2C+Timothy+L&rft.au=Cranmer%2C+Lisa+M&rft.date=2021-03-01&rft.pub=Centers+for+Disease+Control+and+Prevention&rft.issn=1080-6040&rft.eissn=1080-6059&rft.volume=27&rft.issue=3&rft_id=info:doi/10.3201%2Feid2703.203916&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1080-6040&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1080-6040&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1080-6040&client=summon