Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverse neurocognitive outcomes. We have previously identified early deregulation of genes controlling neuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the developing brain. While t...

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Vydáno v:	Glia Ročník 67; číslo 2; s. 345 - 359
Hlavní autoři:	Mairesse, Jérôme, Zinni, Manuela, Pansiot, Julien, Hassan‐Abdi, Rahma, Demene, Charlie, Colella, Marina, Charriaut‐Marlangue, Christiane, Rideau Batista Novais, Aline, Tanter, Mickael, Maccari, Stefania, Gressens, Pierre, Vaiman, Daniel, Soussi‐Yanicostas, Nadia, Baud, Olivier
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken, USA John Wiley & Sons, Inc 01.02.2019 Wiley Subscription Services, Inc Wiley
Témata:	Agonists Animals Animals, Genetically Modified Animals, Newborn Brain Brain - pathology Brain damage Brain Injuries - chemically induced Brain Injuries - drug therapy Brain Injuries - pathology Brain injury Cells, Cultured Cognition Computational Biology Damage prevention Danio rerio Deregulation Diet, Protein-Restricted - adverse effects Dietary supplements Disease Models, Animal Female Fetuses Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Head injuries Inflammation Interleukin 1 Interleukin-1beta Life Sciences Lipopolysaccharides - toxicity Low protein diet Microglia Microglia - drug effects Myelination Neural networks Neurobiology Neuromodulation Neurons and Cognition Neuroprotection Nutrient deficiency Oxytocics - therapeutic use Oxytocin Oxytocin - analogs & derivatives Oxytocin - therapeutic use Peptide Fragments perinatal stress Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - physiopathology Proteins Receptors, Oxytocin - metabolism RNA, Messenger - metabolism Substantia alba Transcription activation Zebrafish myelination oxytocin perinatal stress microglia neuroprotection
ISSN:	0894-1491, 1098-1136, 1098-1136
On-line přístup:	Získat plný text
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