Impact of time of flight and point spread function on quantitative parameters of lung lesions in 18F-FDG PET/CT

Background Image reconstruction algorithm is one of the important factors affecting the quantitative parameters of PET/CT. The purpose of this study was to investigate the effects of time of flight (TOF) and point spread function (PSF) on quantitative parameters of lung lesions in 18 F-FDG PET/CT. M...

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Published in:BMC medical imaging Vol. 21; no. 1; pp. 1 - 9
Main Authors: Huang, Kemin, Feng, Yanlin, Liang, Weitang, Li, Lin
Format: Journal Article
Language:English
Published: London BioMed Central 13.11.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Algorithms
Cable television broadcasting industry
Computed tomography
Emission computer
Fluorine isotopes
Glycolysis
Image processing
Image reconstruction
Imaging
Lesions
Liver
Lung cancer
Lung diseases
Lungs
Medicine
Medicine & Public Health
Metastasis
Noise
Parameters
Patients
PET imaging
Point spread function
Point spread functions
Positron emission
Positron emission tomography
Quantitative parameters
Radiology
Signal to noise ratio
Standard deviation
Standard uptake value
Time of flight
Tomography
Tumors
United States
Quantitative parameters
Tomography
Emission computer
Time of flight
Standard uptake value
Point spread function
ISSN:1471-2342, 1471-2342
Online Access:Get full text
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Summary:Background Image reconstruction algorithm is one of the important factors affecting the quantitative parameters of PET/CT. The purpose of this study was to investigate the effects of time of flight (TOF) and point spread function (PSF) on quantitative parameters of lung lesions in 18 F-FDG PET/CT. Methods This retrospective study evaluated 60 lung lesions in 39 patients who had undergone 18 F-fluoro-deoxy-glucose (FDG) PET/CT. All lesions larger than 10 mm in diameter were included in the study. The PET data were reconstructed with a baseline ordered-subsets expectation–maximization (OSEM) algorithm, OSEM + PSF, OSEM + TOF and OSEM + TOF + PSF respectively. The differences of maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG)and signal to noise ratio (SNR)were compared among different reconstruction algorithms. Results Compared with OSEM reconstruction, using OSEM + TOF + PSF increased SUVmean and SUVmax by 23.73% and 22.71% respectively, and SNR increased by 70.18%, MTV decreased by 23.84% ( p  < 0.01). The percentage difference was significantly higher in smaller lesions (diameter 10–22 mm) than in larger lesions (diameter 23–44 mm), and significantly higher in low contrast lesions (SNR ≤ 15.31) than in high contrast lesions (SNR > 15.31). The difference of TLG among various reconstruction algorithms is relatively small, the highest value is − 6.48% of OSEM + TOF + PSF, and the lowest value is 0.81% of OSEM + TOF. Conclusion TOF and PSF significantly affected the quantitative parameters of lung lesions in 18 F-FDG PET/CT. OSEM + TOF + PSF can significantly increased SUVmax, SUVmean and SNR, and significantly reduce MTV, especially in small lesions and low contrast lesions. TLG can be relatively stable in different reconstruction algorithms.
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ISSN:1471-2342
1471-2342
DOI:10.1186/s12880-021-00699-w