Second-generation autologous chondrocyte transplantation: MRI findings and clinical correlations at a minimum 5-year follow-up

To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters. Fifty consecutive patients were included in the study and evaluated clinically using the Cartilage Sta...

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Vydané v:	European journal of radiology Ročník 79; číslo 3; s. 382 - 388
Hlavní autori:	Kon, E., Di Martino, A., Filardo, G., Tetta, C., Busacca, M., Iacono, F., Delcogliano, M., Albisinni, U., Marcacci, M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Amsterdam Elsevier Ireland Ltd 01.09.2011 Elsevier
Predmet:	Adolescent Adult Analysis of Variance Arthroscopy Biological and medical sciences Cartilage Chi-Square Distribution Chondrocytes - transplantation Female Follow-Up Studies Humans Hyaluronic Acid Knee Knee Injuries - surgery Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Orthopedic surgery Osteoarthritis, Knee - surgery Prospective Studies Radiology Scoring system Second-generation autologous chondrocyte implantation Statistics, Nonparametric Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation, Autologous Treatment Outcome Knee Cartilage Second-generation autologous chondrocyte implantation Magnetic resonance imaging Scoring system Chondrocyte implantation Nuclear magnetic resonance imaging Autograft implantation Orthopedic surgery Treatment Articular cartilage Second-generation autologous chondrocyte Medical imagery
ISSN:	0720-048X, 1872-7727, 1872-7727
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Popis
Shrnutí:	To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters. Fifty consecutive patients were included in the study and evaluated clinically using the Cartilage Standard Evaluation Form as proposed by ICRS and the Tegner score. Forty lesions underwent MRI evaluation at a minimum 5-year follow-up. For the description and evaluation of the graft, we employed the MOCART-scoring system. A statistically significant improvement in all clinical scores was observed at 2 and over 5 years. The total MOCART score and the signal intensity (3D-GE-FS) of the repair tissue were statistically correlated to the IKDC subjective evaluation. Larger size of the treated cartilage lesions had a negative influence on the degree of defect repair and filling, the integration to the border zone and the subchondral lamina integrity, whereas more intensive sport activity had a positive influence on the signal intensity of the repair tissue, the repair tissue surface, and the clinical outcome. Our findings confirm the durability of the clinical results obtained with Hyalograft C and the usefulness of MRI as a non-invasive method for the evaluation of the repaired tissue and the outcome after second-generation autologous transplantation over time.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0720-048X 1872-7727 1872-7727
DOI:	10.1016/j.ejrad.2010.04.002