Second-generation autologous chondrocyte transplantation: MRI findings and clinical correlations at a minimum 5-year follow-up

To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters. Fifty consecutive patients were included in the study and evaluated clinically using the Cartilage Sta...

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Vydáno v:	European journal of radiology Ročník 79; číslo 3; s. 382 - 388
Hlavní autoři:	Kon, E., Di Martino, A., Filardo, G., Tetta, C., Busacca, M., Iacono, F., Delcogliano, M., Albisinni, U., Marcacci, M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier Ireland Ltd 01.09.2011 Elsevier
Témata:	Adolescent Adult Analysis of Variance Arthroscopy Biological and medical sciences Cartilage Chi-Square Distribution Chondrocytes - transplantation Female Follow-Up Studies Humans Hyaluronic Acid Knee Knee Injuries - surgery Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Orthopedic surgery Osteoarthritis, Knee - surgery Prospective Studies Radiology Scoring system Second-generation autologous chondrocyte implantation Statistics, Nonparametric Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation, Autologous Treatment Outcome Knee Cartilage Second-generation autologous chondrocyte implantation Magnetic resonance imaging Scoring system Chondrocyte implantation Nuclear magnetic resonance imaging Autograft implantation Orthopedic surgery Treatment Articular cartilage Second-generation autologous chondrocyte Medical imagery
ISSN:	0720-048X, 1872-7727, 1872-7727
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Abstract	To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters. Fifty consecutive patients were included in the study and evaluated clinically using the Cartilage Standard Evaluation Form as proposed by ICRS and the Tegner score. Forty lesions underwent MRI evaluation at a minimum 5-year follow-up. For the description and evaluation of the graft, we employed the MOCART-scoring system. A statistically significant improvement in all clinical scores was observed at 2 and over 5 years. The total MOCART score and the signal intensity (3D-GE-FS) of the repair tissue were statistically correlated to the IKDC subjective evaluation. Larger size of the treated cartilage lesions had a negative influence on the degree of defect repair and filling, the integration to the border zone and the subchondral lamina integrity, whereas more intensive sport activity had a positive influence on the signal intensity of the repair tissue, the repair tissue surface, and the clinical outcome. Our findings confirm the durability of the clinical results obtained with Hyalograft C and the usefulness of MRI as a non-invasive method for the evaluation of the repaired tissue and the outcome after second-generation autologous transplantation over time.
AbstractList	To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters.OBJECTIVETo evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters.Fifty consecutive patients were included in the study and evaluated clinically using the Cartilage Standard Evaluation Form as proposed by ICRS and the Tegner score. Forty lesions underwent MRI evaluation at a minimum 5-year follow-up. For the description and evaluation of the graft, we employed the MOCART-scoring system.METHODSFifty consecutive patients were included in the study and evaluated clinically using the Cartilage Standard Evaluation Form as proposed by ICRS and the Tegner score. Forty lesions underwent MRI evaluation at a minimum 5-year follow-up. For the description and evaluation of the graft, we employed the MOCART-scoring system.A statistically significant improvement in all clinical scores was observed at 2 and over 5 years. The total MOCART score and the signal intensity (3D-GE-FS) of the repair tissue were statistically correlated to the IKDC subjective evaluation. Larger size of the treated cartilage lesions had a negative influence on the degree of defect repair and filling, the integration to the border zone and the subchondral lamina integrity, whereas more intensive sport activity had a positive influence on the signal intensity of the repair tissue, the repair tissue surface, and the clinical outcome.RESULTSA statistically significant improvement in all clinical scores was observed at 2 and over 5 years. The total MOCART score and the signal intensity (3D-GE-FS) of the repair tissue were statistically correlated to the IKDC subjective evaluation. Larger size of the treated cartilage lesions had a negative influence on the degree of defect repair and filling, the integration to the border zone and the subchondral lamina integrity, whereas more intensive sport activity had a positive influence on the signal intensity of the repair tissue, the repair tissue surface, and the clinical outcome.Our findings confirm the durability of the clinical results obtained with Hyalograft C and the usefulness of MRI as a non-invasive method for the evaluation of the repaired tissue and the outcome after second-generation autologous transplantation over time.CONCLUSIONOur findings confirm the durability of the clinical results obtained with Hyalograft C and the usefulness of MRI as a non-invasive method for the evaluation of the repaired tissue and the outcome after second-generation autologous transplantation over time. To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters. Fifty consecutive patients were included in the study and evaluated clinically using the Cartilage Standard Evaluation Form as proposed by ICRS and the Tegner score. Forty lesions underwent MRI evaluation at a minimum 5-year follow-up. For the description and evaluation of the graft, we employed the MOCART-scoring system. A statistically significant improvement in all clinical scores was observed at 2 and over 5 years. The total MOCART score and the signal intensity (3D-GE-FS) of the repair tissue were statistically correlated to the IKDC subjective evaluation. Larger size of the treated cartilage lesions had a negative influence on the degree of defect repair and filling, the integration to the border zone and the subchondral lamina integrity, whereas more intensive sport activity had a positive influence on the signal intensity of the repair tissue, the repair tissue surface, and the clinical outcome. Our findings confirm the durability of the clinical results obtained with Hyalograft C and the usefulness of MRI as a non-invasive method for the evaluation of the repaired tissue and the outcome after second-generation autologous transplantation over time. Abstract Objective To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate it with the MRI evaluation parameters. Methods Fifty consecutive patients were included in the study and evaluated clinically using the Cartilage Standard Evaluation Form as proposed by ICRS and the Tegner score. Forty lesions underwent MRI evaluation at a minimum 5-year follow-up. For the description and evaluation of the graft, we employed the MOCART-scoring system. Results A statistically significant improvement in all clinical scores was observed at 2 and over 5 years. The total MOCART score and the signal intensity (3D-GE-FS) of the repair tissue were statistically correlated to the IKDC subjective evaluation. Larger size of the treated cartilage lesions had a negative influence on the degree of defect repair and filling, the integration to the border zone and the subchondral lamina integrity, whereas more intensive sport activity had a positive influence on the signal intensity of the repair tissue, the repair tissue surface, and the clinical outcome. Conclusion Our findings confirm the durability of the clinical results obtained with Hyalograft C and the usefulness of MRI as a non-invasive method for the evaluation of the repaired tissue and the outcome after second-generation autologous transplantation over time.
Author	Filardo, G. Tetta, C. Albisinni, U. Di Martino, A. Kon, E. Marcacci, M. Iacono, F. Delcogliano, M. Busacca, M.
Author_xml	– sequence: 1 givenname: E. surname: Kon fullname: Kon, E. organization: Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, 40136 Bologna, Italy – sequence: 2 givenname: A. surname: Di Martino fullname: Di Martino, A. email: a.dimartino@biomec.ior.it organization: Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, 40136 Bologna, Italy – sequence: 3 givenname: G. surname: Filardo fullname: Filardo, G. organization: Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, 40136 Bologna, Italy – sequence: 4 givenname: C. surname: Tetta fullname: Tetta, C. organization: Radiology, Rizzoli Orthopaedic Institute, Bologna, Italy – sequence: 5 givenname: M. surname: Busacca fullname: Busacca, M. organization: Radiology, Rizzoli Orthopaedic Institute, Bologna, Italy – sequence: 6 givenname: F. surname: Iacono fullname: Iacono, F. organization: Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, 40136 Bologna, Italy – sequence: 7 givenname: M. surname: Delcogliano fullname: Delcogliano, M. organization: Orthopaedic Departement San Carlo di Nancy Hospital, Rome, Italy – sequence: 8 givenname: U. surname: Albisinni fullname: Albisinni, U. organization: Radiology, Rizzoli Orthopaedic Institute, Bologna, Italy – sequence: 9 givenname: M. surname: Marcacci fullname: Marcacci, M. organization: Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, 40136 Bologna, Italy
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Keywords	Knee Cartilage Second-generation autologous chondrocyte implantation Magnetic resonance imaging Scoring system Chondrocyte implantation Nuclear magnetic resonance imaging Autograft implantation Orthopedic surgery Treatment Articular cartilage Second-generation autologous chondrocyte Medical imagery
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Snippet	To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of follow-up and to correlate... Abstract Objective To evaluate the clinical outcome of hyaluronan-based arthroscopic autologous chondrocyte transplantation at a minimum of 5 years of...
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SubjectTerms	Adolescent Adult Analysis of Variance Arthroscopy Biological and medical sciences Cartilage Chi-Square Distribution Chondrocytes - transplantation Female Follow-Up Studies Humans Hyaluronic Acid Knee Knee Injuries - surgery Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Orthopedic surgery Osteoarthritis, Knee - surgery Prospective Studies Radiology Scoring system Second-generation autologous chondrocyte implantation Statistics, Nonparametric Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation, Autologous Treatment Outcome
Title	Second-generation autologous chondrocyte transplantation: MRI findings and clinical correlations at a minimum 5-year follow-up
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