Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans

Monocytes play critical roles in tissue injury and repair following acute myocardial infarction (AMI). Specifically targeting inflammatory monocytes in experimental models leads to reduced infarct size and improved healing. However, data from humans are sparse, and it remains unclear whether monocyt...

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Bibliographic Details
Published in:	European heart journal Vol. 36; no. 29; p. 1923
Main Authors:	Ruparelia, Neil, Godec, Jernej, Lee, Regent, Chai, Joshua T, Dall'Armellina, Erica, McAndrew, Debra, Digby, Janet E, Forfar, J Colin, Prendergast, Bernard D, Kharbanda, Rajesh K, Banning, Adrian P, Neubauer, Stefan, Lygate, Craig A, Channon, Keith M, Haining, Nicholas W, Choudhury, Robin P
Format:	Journal Article
Language:	English
Published:	England 01.08.2015
Subjects:	Aged Animals Case-Control Studies Cell Proliferation - physiology Female Gene Expression Profiling Humans Inflammation - immunology Inflammation - pathology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - pathology Ligation Magnetic Resonance Angiography Male Mice, Inbred C57BL Middle Aged Myocardial Infarction - genetics Myocardial Infarction - immunology Myocardial Infarction - pathology Phenotype Transcription, Genetic - genetics Transcription, Genetic - immunology Transcriptional Activation - physiology Monocytes Inflammation Acute myocardial infarction Mitosis Genomics
ISSN:	1522-9645, 1522-9645
Online Access:	Get more information
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