Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and potent small-molecule inhibitor of Gal-3.A randomised, double-blind, multicentre, placebo-controlled, phase 1/2a...

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Bibliographic Details

Published in:	The European respiratory journal Vol. 57; no. 5
Main Authors:	Hirani, Nikhil, MacKinnon, Alison C, Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J, Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J, Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L, Li, Feng, Funston, Wendy, Forrest, Ian A, Simpson, A John, Gibbons, Michael A, Maher, Toby M
Format:	Journal Article
Language:	English
Published:	England 01.05.2021
Subjects:	Double-Blind Method Galectin 3 Humans Idiopathic Pulmonary Fibrosis Lung
ISSN:	1399-3003, 1399-3003
Online Access:	Get more information
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