Work Productivity in Relapsing Multiple Sclerosis: Associations with Disability, Depression, Fatigue, Anxiety, Cognition, and Health-Related Quality of Life

To characterize work productivity in relapsing multiple sclerosis (MS) by using a work productivity scale and to identify associations between work productivity and disability, depression, fatigue, anxiety, cognition, and health-related quality of life. Three hundred seventy-seven subjects with a cl...

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Veröffentlicht in:Value in health Jg. 15; H. 8; S. 1029 - 1035
Hauptverfasser: Glanz, Bonnie I., Dégano, Irene R., Rintell, David J., Chitnis, Tanuja, Weiner, Howard L., Healy, Brian C.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.12.2012
Schlagworte:
Absenteeism
Adult
Anxiety - ethnology
Anxiety - etiology
Anxiety-Depression
Cognition Disorders - ethnology
Cognition Disorders - etiology
depression
Depression - ethnology
Depression - etiology
Disabled Persons - psychology
Disabled Persons - statistics & numerical data
Efficiency
Fatigue
Fatigue - ethnology
Fatigue - etiology
Female
Humans
Internal Medicine
Male
Mental Health - ethnology
Mental Health - statistics & numerical data
Middle Aged
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - ethnology
Multiple Sclerosis - psychology
Productivity
Quality of Life
work productivity
fatigue
depression
work productivity
quality of life
multiple sclerosis
ISSN:1098-3015, 1524-4733, 1524-4733
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Zusammenfassung:To characterize work productivity in relapsing multiple sclerosis (MS) by using a work productivity scale and to identify associations between work productivity and disability, depression, fatigue, anxiety, cognition, and health-related quality of life. Three hundred seventy-seven subjects with a clinically isolated syndrome or relapsing remitting MS participated in the study. Subjects underwent neurological examinations and completed patient-reported outcome and cognitive measures. Subjects also completed the Work Productivity and Activity Impairment Questionnaire: General Health to quantify absenteeism (missing work because of health problems), presenteeism (impairment while working), overall work impairment, and daily activity impairment attributable to health problems. Univariate correlations and multivariate models were used to determine the associations between each work productivity variable and clinical, patient-reported outcome, and cognitive measures. Seventy-six percent of subjects were employed. Fourteen percent of working subjects reported absenteeism, and 47% reported presenteeism. The mean work time lost because of absenteeism was 4%, and the mean work time lost because of presenteeism was 12%. Absenteeism was not significantly associated with disease or patient-reported outcome measures. Statistically significant correlations (0.32–0.53) were found between presenteeism and increasing disability, fatigue, depression, anxiety, and reduced quality of life. No associations were observed between presenteeism and disease duration or cognitive function. Subjects with clinically isolated syndrome/relapsing remitting MS reported substantial work productivity losses due to presenteesim. Presenteeism was associated with increasing fatigue, depression, anxiety, and reduced quality of life. It is possible that the early identification and treatment of fatigue and mental health symptoms may improve productivity while working and extend employment for individuals with MS.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1098-3015
1524-4733
1524-4733
DOI:10.1016/j.jval.2012.07.010