Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort

Onset of multiple sclerosis (MS) is typically in early adulthood. The impact, if any, of menopause on the MS course is unknown. Our objective was to determine whether menopause is associated with changes in MS severity in a longitudinal clinical cohort. Responses from an ongoing reproductive questio...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Multiple sclerosis Ročník 22; číslo 7; s. 935
Hlavní autoři:	Bove, Riley, Healy, Brian C, Musallam, Alexander, Glanz, Bonnie I, De Jager, Philip L, Chitnis, Tanuja
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.06.2016
Témata:	Adult Demyelinating Diseases - diagnosis Demyelinating Diseases - physiopathology Disability Evaluation Disease Progression Female Humans Longitudinal Studies Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - physiopathology Postmenopause Predictive Value of Tests Prognosis Retrospective Studies Severity of Illness Index Surveys and Questionnaires Time Factors Young Adult estrogen menopause patient reported outcome disability multiple sclerosis hormone replacement therapy oophorectomy disease progression quality of life Clinically isolated syndrome
ISSN:	1477-0970, 1477-0970
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Onset of multiple sclerosis (MS) is typically in early adulthood. The impact, if any, of menopause on the MS course is unknown. Our objective was to determine whether menopause is associated with changes in MS severity in a longitudinal clinical cohort. Responses from an ongoing reproductive questionnaire deployed in all active female CLIMB observational study participants with a diagnosis of clinically isolated syndrome (CIS) or MS were analyzed when the response rate was 60%. Reproductive data were linked with clinical severity measures that were prospectively collected every six months, including our primary measure, the Expanded Disability Status Scale (EDSS). Over one-half of the respondents (368 of 724 women) were postmenopausal. Median age at natural menopause was 51.5 years. In our primary analysis of 124 women who were followed longitudinally (mean duration 10.4 years) through their menopausal transition (natural or surgical), menopause represented an inflection point in their EDSS changes (difference of 0.076 units; 95% CI 0.010-0.14; p = 0.024). These findings were not explained by vitamin D levels, nor changes in treatment or smoking status over this period. There was no effect of hormone replacement therapy (HRT) exposure, but HRT use was low. We observed a possible worsening of MS disability after menopause. Larger cohorts are required to assess any HRT effects.
AbstractList	Onset of multiple sclerosis (MS) is typically in early adulthood. The impact, if any, of menopause on the MS course is unknown. Our objective was to determine whether menopause is associated with changes in MS severity in a longitudinal clinical cohort. Responses from an ongoing reproductive questionnaire deployed in all active female CLIMB observational study participants with a diagnosis of clinically isolated syndrome (CIS) or MS were analyzed when the response rate was 60%. Reproductive data were linked with clinical severity measures that were prospectively collected every six months, including our primary measure, the Expanded Disability Status Scale (EDSS). Over one-half of the respondents (368 of 724 women) were postmenopausal. Median age at natural menopause was 51.5 years. In our primary analysis of 124 women who were followed longitudinally (mean duration 10.4 years) through their menopausal transition (natural or surgical), menopause represented an inflection point in their EDSS changes (difference of 0.076 units; 95% CI 0.010-0.14; p = 0.024). These findings were not explained by vitamin D levels, nor changes in treatment or smoking status over this period. There was no effect of hormone replacement therapy (HRT) exposure, but HRT use was low. We observed a possible worsening of MS disability after menopause. Larger cohorts are required to assess any HRT effects. Onset of multiple sclerosis (MS) is typically in early adulthood. The impact, if any, of menopause on the MS course is unknown. Our objective was to determine whether menopause is associated with changes in MS severity in a longitudinal clinical cohort.BACKGROUNDOnset of multiple sclerosis (MS) is typically in early adulthood. The impact, if any, of menopause on the MS course is unknown. Our objective was to determine whether menopause is associated with changes in MS severity in a longitudinal clinical cohort.Responses from an ongoing reproductive questionnaire deployed in all active female CLIMB observational study participants with a diagnosis of clinically isolated syndrome (CIS) or MS were analyzed when the response rate was 60%. Reproductive data were linked with clinical severity measures that were prospectively collected every six months, including our primary measure, the Expanded Disability Status Scale (EDSS).METHODSResponses from an ongoing reproductive questionnaire deployed in all active female CLIMB observational study participants with a diagnosis of clinically isolated syndrome (CIS) or MS were analyzed when the response rate was 60%. Reproductive data were linked with clinical severity measures that were prospectively collected every six months, including our primary measure, the Expanded Disability Status Scale (EDSS).Over one-half of the respondents (368 of 724 women) were postmenopausal. Median age at natural menopause was 51.5 years. In our primary analysis of 124 women who were followed longitudinally (mean duration 10.4 years) through their menopausal transition (natural or surgical), menopause represented an inflection point in their EDSS changes (difference of 0.076 units; 95% CI 0.010-0.14; p = 0.024). These findings were not explained by vitamin D levels, nor changes in treatment or smoking status over this period. There was no effect of hormone replacement therapy (HRT) exposure, but HRT use was low.RESULTSOver one-half of the respondents (368 of 724 women) were postmenopausal. Median age at natural menopause was 51.5 years. In our primary analysis of 124 women who were followed longitudinally (mean duration 10.4 years) through their menopausal transition (natural or surgical), menopause represented an inflection point in their EDSS changes (difference of 0.076 units; 95% CI 0.010-0.14; p = 0.024). These findings were not explained by vitamin D levels, nor changes in treatment or smoking status over this period. There was no effect of hormone replacement therapy (HRT) exposure, but HRT use was low.We observed a possible worsening of MS disability after menopause. Larger cohorts are required to assess any HRT effects.CONCLUSIONSWe observed a possible worsening of MS disability after menopause. Larger cohorts are required to assess any HRT effects.
Author	Glanz, Bonnie I Healy, Brian C Bove, Riley Musallam, Alexander Chitnis, Tanuja De Jager, Philip L
Author_xml	– sequence: 1 givenname: Riley surname: Bove fullname: Bove, Riley organization: Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, USA/Harvard Medical School, Boston, MA, USA/Center for Neurologic Diseases, Harvard Medical School, Boston, MA, USA – sequence: 2 givenname: Brian C surname: Healy fullname: Healy, Brian C organization: Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, USA/Harvard Medical School, Boston, MA, USA/Harvard Medical School, Boston, MA, USA/Center for Neurologic Diseases, Harvard Medical School, Boston, MA, USA/Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA – sequence: 3 givenname: Alexander surname: Musallam fullname: Musallam, Alexander organization: Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, USA – sequence: 4 givenname: Bonnie I surname: Glanz fullname: Glanz, Bonnie I organization: Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, USA/Harvard Medical School, Boston, MA, USA – sequence: 5 givenname: Philip L surname: De Jager fullname: De Jager, Philip L organization: Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, USA/Harvard Medical School, Boston, MA, USA/Center for Neurologic Diseases, Harvard Medical School, Boston, MA, USA – sequence: 6 givenname: Tanuja surname: Chitnis fullname: Chitnis, Tanuja email: tchitnis@rics.bwh.harvard.edu organization: Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, USA/Harvard Medical School, Boston, MA, USA/Center for Neurologic Diseases, Harvard Medical School, Boston, MA, USA tchitnis@rics.bwh.harvard.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26447063$$D View this record in MEDLINE/PubMed
BookMark	eNpNkDtPwzAUhS0Eog_YmZBHloCv7cTNiKrykCqxwBxunZvWyLFDnEj030NFkZjOkc6nM3wzdhpiIMauQNwCGHMHKpc6X-SQF6KQACdsCtqYTJRGnP7rEzZL6UMIYYzKz9lEFlobUagpe199dT72OLgYeGy43WHYUuIu8Nol3Djvhj3HZqCetxRih2Oiw4rcx7B1w1i7gJ63ox9c54kn66mPySVu4y72wwU7a9AnujzmnL09rF6XT9n65fF5eb_OrC7zIdMGDQESNGRA2A2pulS4yAVggbXSoKyVBCAWdaGLEjQKJWVJqtFUNFjKObv5_e36-DlSGqrWJUveY6A4pgpMqcqDAPGDXh_RcdNSXXW9a7HfV39W5DcgwmcZ
CitedBy_id	crossref_primary_10_1007_s13311_017_0577_0 crossref_primary_10_1177_1756286420936166 crossref_primary_10_1016_j_msard_2022_104098 crossref_primary_10_3389_fneur_2020_00616 crossref_primary_10_1002_hsr2_1738 crossref_primary_10_1212_NXI_0000000000000339 crossref_primary_10_3389_fneur_2023_1268411 crossref_primary_10_1038_s41467_023_41723_7 crossref_primary_10_1080_14737175_2021_1886082 crossref_primary_10_1212_WNL_0000000000003176 crossref_primary_10_3389_fimmu_2023_1175874 crossref_primary_10_1016_j_brainres_2019_146352 crossref_primary_10_1016_j_ncl_2023_07_003 crossref_primary_10_1016_j_ncl_2023_07_004 crossref_primary_10_1084_jem_20211488 crossref_primary_10_3389_fneur_2023_1286122 crossref_primary_10_1007_s11910_020_01046_2 crossref_primary_10_1007_s11910_018_0846_2 crossref_primary_10_1111_ene_15299 crossref_primary_10_1016_j_yfrne_2018_07_001 crossref_primary_10_3389_fimmu_2022_933415 crossref_primary_10_1177_13524585241254987 crossref_primary_10_1136_jnnp_2019_320587 crossref_primary_10_1111_jon_12709 crossref_primary_10_1093_brain_awaa251 crossref_primary_10_1016_j_msard_2021_103084 crossref_primary_10_1212_NXI_0000000000200106 crossref_primary_10_1016_j_msard_2022_103793 crossref_primary_10_1186_s13293_024_00618_y crossref_primary_10_1007_s11910_023_01326_7 crossref_primary_10_1177_13524585231197056 crossref_primary_10_1371_journal_pone_0238476 crossref_primary_10_1016_j_autrev_2023_103363 crossref_primary_10_1136_jnnp_2022_328994 crossref_primary_10_2147_IJWH_S334719 crossref_primary_10_3389_fneur_2021_554375 crossref_primary_10_3389_fneur_2022_1104552 crossref_primary_10_1016_S1474_4422_22_00184_3 crossref_primary_10_4045_tidsskr_25_0070 crossref_primary_10_1080_17582024_2025_2489878 crossref_primary_10_1007_s12017_017_8443_0 crossref_primary_10_1177_1352458519892491 crossref_primary_10_1111_ene_14782 crossref_primary_10_1007_s11845_016_1544_1 crossref_primary_10_1111_ene_16566 crossref_primary_10_1177_1352458520952022 crossref_primary_10_1177_1352458519865118 crossref_primary_10_1016_j_msard_2022_103747 crossref_primary_10_1212_NXG_0000000000000088 crossref_primary_10_37989_gumussagbil_1558812 crossref_primary_10_1007_s11910_024_01333_2 crossref_primary_10_1212_WNL_0000000000210228 crossref_primary_10_1212_WNL_0000000000004843 crossref_primary_10_1007_s11910_021_01115_0 crossref_primary_10_3389_fneur_2023_1251667 crossref_primary_10_1016_j_jneuroim_2025_578589 crossref_primary_10_1007_s00415_024_12384_3 crossref_primary_10_3389_fneur_2024_1355817 crossref_primary_10_1016_j_msard_2024_105517 crossref_primary_10_1016_j_yfrne_2020_100889 crossref_primary_10_1371_journal_pone_0297091 crossref_primary_10_1177_1352458517692420 crossref_primary_10_1177_1352458517737396 crossref_primary_10_1016_j_yfrne_2024_101172 crossref_primary_10_1080_13697137_2023_2221381 crossref_primary_10_1016_j_yexmp_2017_11_004
ContentType	Journal Article
Copyright	The Author(s), 2015.
Copyright_xml	– notice: The Author(s), 2015.
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1177/1352458515606211
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1477-0970
ExternalDocumentID	26447063
Genre	Journal Article Observational Study
GrantInformation_xml	– fundername: NICHD NIH HHS grantid: K12 HD051959
GroupedDBID	--- -TM .2E .2F .2G .2J .2N 01A 0R~ 123 18M 1~K 29M 31R 31S 31U 31X 31Y 31Z 36B 39C 4.4 53G 54M 5VS 7X7 88E 8FI 8FJ 8R4 8R5 AABMB AABOD AACKU AACMV AACTG AADUE AAEJI AAEWN AAGGD AAGLT AAGMC AAJIQ AAJOX AAJPV AAKGS AANSI AAPEO AAPII AAQDB AAQXH AAQXI AARDL AARIX AATAA AATBZ AAUAS AAXOT AAYTG AAZBJ ABAFQ ABAWC ABAWP ABCCA ABCJG ABDWY ABEIX ABFWQ ABHFT ABHKI ABHQH ABIDT ABJIS ABJNI ABJZC ABKRH ABLUO ABNCE ABPGX ABPNF ABQKF ABQXT ABRHV ABUJY ABUWG ABVFX ABVVC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFO ACGFS ACGZU ACJER ACJTF ACLFY ACLHI ACLZU ACNXM ACOFE ACOXC ACPRK ACROE ACRPL ACSIQ ACUAV ACUIR ACXKE ACXMB ADBBV ADDLC ADEBD ADEIA ADMPF ADNBR ADNMO ADNON ADRRZ ADSTG ADTBJ ADUCT ADUKL ADVBO ADYCS ADZYD ADZZY AECGH AECVZ AEDTQ AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEWDL AEWHI AEXFG AEXNY AFEET AFKBI AFKRA AFKRG AFMOU AFQAA AFUIA AFVCE AFWMB AGHKR AGKLV AGNHF AGPXR AGQPQ AGWFA AGWNL AHDMH AHHFK AHMBA AIGRN AJABX AJEFB AJGYC AJMMQ AJSCY AJUZI AJVBE AJXAJ AJXGE ALIPV ALKWR ALMA_UNASSIGNED_HOLDINGS AMCVQ ANDLU ARTOV ASPBG AUTPY AVWKF AYAKG AZFZN AZQEC B3H B8M B8O B8R B8Z B93 B94 BBRGL BDDNI BENPR BKIIM BKNYI BKSCU BPACV BPHCQ BSEHC BVXVI BWJAD BYIEH CAG CBRKF CCPQU CDWPY CFDXU CGR COF CORYS CQQTX CS3 CUTAK CUY CVF DB0 DC- DC0 DD- DD0 DE- DF0 DO- DOPDO DU5 DV7 DV9 D~Y EBS ECM EIF EJD EMOBN F5P FD6 FEDTE FHBDP FYUFA GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION H13 HF~ HMCUK HVGLF HZ~ J8X K.F K.J K9- M0R M1P N9A NPM O9- P.B P2P PHGZM PHGZT PJZUB PPXIY PQQKQ PROAC PSQYO Q1R Q2X Q7K Q7L Q7R Q7U Q7X Q82 Q83 ROL S01 SASJQ SAUOL SCNPE SDB SFB SFC SFK SFN SFT SGA SGO SGP SGR SGV SGX SGZ SHG SNB SPJ SPQ SPV SQCSI STM UKHRP XJT ZONMY ZPPRI ZRKOI ZSSAH 7X8 AJHME
ID	FETCH-LOGICAL-c495t-47a7e1ae1fe710cbe3d93a8501a6ad3413cc2e1108d646914a03229e3f4e6fa92
IEDL.DBID	7X8
ISICitedReferencesCount	69
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000378449400014&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1477-0970
IngestDate	Wed Oct 01 07:43:16 EDT 2025 Mon Jul 21 06:04:50 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	7
Keywords	estrogen menopause patient reported outcome disability multiple sclerosis hormone replacement therapy oophorectomy disease progression quality of life Clinically isolated syndrome
Language	English
License	The Author(s), 2015.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c495t-47a7e1ae1fe710cbe3d93a8501a6ad3413cc2e1108d646914a03229e3f4e6fa92
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
OpenAccessLink	http://doi.org/10.1177/1352458515606211
PMID	26447063
PQID	1793900770
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_1793900770 pubmed_primary_26447063
PublicationCentury	2000
PublicationDate	2016-06-01
PublicationDateYYYYMMDD	2016-06-01
PublicationDate_xml	– month: 06 year: 2016 text: 2016-06-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Multiple sclerosis
PublicationTitleAlternate	Mult Scler
PublicationYear	2016
References	23555057 - Mult Scler Int. 2013;2013:189624 23822612 - BMC Neurol. 2013 Jul 03;13:73 8148458 - Clin Infect Dis. 1994 Jan;18 Suppl 1:S79-83 8161978 - Qual Life Res. 1993 Dec;2(6):441-9 21762931 - J Neurol Sci. 2011 Dec 15;311(1-2):19-22 24834516 - Nature. 2014 May 15;509(7500):282-3 15177058 - Parkinsonism Relat Disord. 2002 Jun;8(5):289-95 23527256 - PLoS One. 2013;8(3):e59707 19014588 - Health Qual Life Outcomes. 2008 Nov 14;6:100 24598886 - J Nutr. 2014 May;144(5):681-9 1433038 - J R Soc Med. 1992 Oct;85(10):612-3 16283615 - Ann Neurol. 2005 Dec;58(6):840-6 24561324 - Mult Scler. 2014 Apr;20(5):520-6 16688016 - Neurologist. 2006 May;12(3):149-59 16293376 - Maturitas. 2006 May 20;54(2):149-53 25787049 - Mult Scler Relat Disord. 2015 Jan;4(1):18-24 23100399 - Neurology. 2012 Oct 30;79(18):1846-52 22612605 - Climacteric. 2012 Jun;15(3):206-12 11821342 - Int J Epidemiol. 2001 Dec;30(6):1332-41 22736750 - Mult Scler. 2013 Feb;19(2):188-98 24336141 - Neurology. 2014 Jan 21;82(3):222-9 22344196 - J Clin Endocrinol Metab. 2012 Apr;97(4):1159-68 21660468 - Arch Gynecol Obstet. 2011 Sep;284(3):749-55 10467383 - Mult Scler. 1999 Aug;5(4):244-50 6685237 - Neurology. 1983 Nov;33(11):1444-52 23263867 - Lupus. 2013 Jan;22(1):81-6 22383227 - Mult Scler. 2012 Oct;18(10):1472-9 20965156 - Brain Res. 2011 Mar 16;1379:188-98 22760102 - Mult Scler. 2013 Mar;19(3):351-8 20418030 - Maturitas. 2010 Jul;66(3):327-8 22209870 - Front Neuroendocrinol. 2012 Jan;33(1):105-15 11323317 - Am J Epidemiol. 2001 May 1;153(9):865-74
References_xml	– reference: 15177058 - Parkinsonism Relat Disord. 2002 Jun;8(5):289-95 – reference: 23100399 - Neurology. 2012 Oct 30;79(18):1846-52 – reference: 22736750 - Mult Scler. 2013 Feb;19(2):188-98 – reference: 16283615 - Ann Neurol. 2005 Dec;58(6):840-6 – reference: 19014588 - Health Qual Life Outcomes. 2008 Nov 14;6:100 – reference: 22383227 - Mult Scler. 2012 Oct;18(10):1472-9 – reference: 21660468 - Arch Gynecol Obstet. 2011 Sep;284(3):749-55 – reference: 24598886 - J Nutr. 2014 May;144(5):681-9 – reference: 6685237 - Neurology. 1983 Nov;33(11):1444-52 – reference: 25787049 - Mult Scler Relat Disord. 2015 Jan;4(1):18-24 – reference: 16293376 - Maturitas. 2006 May 20;54(2):149-53 – reference: 16688016 - Neurologist. 2006 May;12(3):149-59 – reference: 20418030 - Maturitas. 2010 Jul;66(3):327-8 – reference: 23822612 - BMC Neurol. 2013 Jul 03;13:73 – reference: 8161978 - Qual Life Res. 1993 Dec;2(6):441-9 – reference: 23263867 - Lupus. 2013 Jan;22(1):81-6 – reference: 11821342 - Int J Epidemiol. 2001 Dec;30(6):1332-41 – reference: 22209870 - Front Neuroendocrinol. 2012 Jan;33(1):105-15 – reference: 21762931 - J Neurol Sci. 2011 Dec 15;311(1-2):19-22 – reference: 11323317 - Am J Epidemiol. 2001 May 1;153(9):865-74 – reference: 24561324 - Mult Scler. 2014 Apr;20(5):520-6 – reference: 10467383 - Mult Scler. 1999 Aug;5(4):244-50 – reference: 1433038 - J R Soc Med. 1992 Oct;85(10):612-3 – reference: 22612605 - Climacteric. 2012 Jun;15(3):206-12 – reference: 20965156 - Brain Res. 2011 Mar 16;1379:188-98 – reference: 8148458 - Clin Infect Dis. 1994 Jan;18 Suppl 1:S79-83 – reference: 23555057 - Mult Scler Int. 2013;2013:189624 – reference: 24336141 - Neurology. 2014 Jan 21;82(3):222-9 – reference: 22344196 - J Clin Endocrinol Metab. 2012 Apr;97(4):1159-68 – reference: 23527256 - PLoS One. 2013;8(3):e59707 – reference: 24834516 - Nature. 2014 May 15;509(7500):282-3 – reference: 22760102 - Mult Scler. 2013 Mar;19(3):351-8
SSID	ssj0007735
Score	2.4366581
Snippet	Onset of multiple sclerosis (MS) is typically in early adulthood. The impact, if any, of menopause on the MS course is unknown. Our objective was to determine...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	935
SubjectTerms	Adult Demyelinating Diseases - diagnosis Demyelinating Diseases - physiopathology Disability Evaluation Disease Progression Female Humans Longitudinal Studies Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - physiopathology Postmenopause Predictive Value of Tests Prognosis Retrospective Studies Severity of Illness Index Surveys and Questionnaires Time Factors Young Adult
Title	Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort
URI	https://www.ncbi.nlm.nih.gov/pubmed/26447063 https://www.proquest.com/docview/1793900770
Volume	22
WOSCitedRecordID	wos000378449400014&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB7UFfHi-7G-iOC12LSxaU4i4uLBXfagsLc6TVNYkHbddgX_vTNtlz0JgpdeSmjJTOb7kpnMB3CDqZIEg5kXG4xogyLRw5yCYRTLUFvDINVY-kWPRvFkYsbdgVvVlVUuY2ITqLPS8hn5LTuS4eYz_v3s02PVKM6udhIa69ALicqwV-vJqlu41o3AplRae77R_ipNeSuJeChOiRHiR4GUvxPMBmgGu__9xT3Y6SimeGh9Yh_WXHEAW8MuiX4I723dXWMSUeaivftbiWkhsq7jbv0tGvFwwb3EZ7ioHL9F8VGyvNEiYyktsaxFFBV9hsB2WgmW253XR_A2eHp9fPY6oQXP0v6o9pRG7SQ6mTsiHDZ1YWZCjO_IchFmjHPWBo4vDGQRbaelQp_igHFhrlyUowmOYaMoC3cKIg6sVDKlsUGqrB9jjKnvrB-40ITELvpwvZy7hByZsxNYuHJRJavZ68NJa4Bk1nbcSJi1aSJTZ38YfQ7bRGqitpzrAno5LWN3CZv2q55W86vGQ-g5Gg9_AMwLxP4
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exploration+of+changes+in+disability+after+menopause+in+a+longitudinal+multiple+sclerosis+cohort&rft.jtitle=Multiple+sclerosis&rft.au=Bove%2C+Riley&rft.au=Healy%2C+Brian+C&rft.au=Musallam%2C+Alexander&rft.au=Glanz%2C+Bonnie+I&rft.date=2016-06-01&rft.issn=1477-0970&rft.eissn=1477-0970&rft.volume=22&rft.issue=7&rft.spage=935&rft_id=info:doi/10.1177%2F1352458515606211&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1477-0970&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1477-0970&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1477-0970&client=summon