Deficiency of miR-155 in Leukemic B-Cells Results in Cell Cycle Arrest and Deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network

Cell cycle progression and leukemia development are tightly regulated processes in which even a small imbalance in the expression of cell cycle regulatory molecules and microRNAs (miRNAs) can lead to an increased risk of cancer/leukemia development. Here, we focus on the study of a ubiquitous, multi...

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Bibliographic Details
Published in:	Archives of medical research Vol. 56; no. 3; p. 103124
Main Authors:	Golovina, Elena, Kokavec, Juraj, Kazantsev, Dmitry, Yurikova, Oxana, Bajecny, Martin, Savvulidi, Filipp Georgijevic, Simersky, Radim, Lenobel, Rene, Tost, Jorg, Herynek, Vit, Sefc, Ludek, Sebela, Marek, Klener, Pavel, Zemanova, Zuzana, Stopka, Tomas, Vargova, Karina Savvulidi
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.04.2025 Elsevier
Subjects:	B-cells Biochemistry, Molecular Biology Carrier Proteins - genetics Carrier Proteins - metabolism Cell cycle Cell Cycle Checkpoints - genetics Cell Line, Tumor Cell Proliferation - genetics CRISPR/Cas9 Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Gene Expression Regulation, Leukemic Genomics Heat-Shock Proteins Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Life Sciences MicroRNAs - genetics MicroRNAs - metabolism miR-155 B-cells CRISPR/Cas9 miR-155 Leukemia Cell cycle miR-155 CRISPR/Cas9 Cell cycle B-cells Leukemia
ISSN:	0188-4409, 1873-5487, 1873-5487
Online Access:	Get full text
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