Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury

Cellular processes that drive sterile inflammatory injury after hepatic ischemia/reperfusion (I/R) injury are not completely understood. Activation of the inflammasome plays a key role in response to invading intracellular pathogens, but mounting evidence suggests that it also plays a role in inflam...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 191; no. 5; p. 2665
Main Authors:	Huang, Hai, Chen, Hui-Wei, Evankovich, John, Yan, Wei, Rosborough, Brian R, Nace, Gary W, Ding, Qing, Loughran, Patricia, Beer-Stolz, Donna, Billiar, Timothy R, Esmon, Charles T, Tsung, Allan
Format:	Journal Article
Language:	English
Published:	United States 01.09.2013
Subjects:	Animals Blotting, Western Carrier Proteins - immunology Carrier Proteins - metabolism Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Histones - immunology Histones - metabolism Immunity, Innate - immunology Inflammasomes - immunology Inflammasomes - metabolism Kupffer Cells - immunology Kupffer Cells - metabolism Liver - immunology Liver - injuries Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal NLR Family, Pyrin Domain-Containing 3 Protein Real-Time Polymerase Chain Reaction Reperfusion Injury - immunology Reverse Transcriptase Polymerase Chain Reaction
ISSN:	1550-6606, 1550-6606
Online Access:	Get more information
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