Sodium Nitrite Improves Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction

There is no effective medical treatment for heart failure with preserved ejection fraction (HFpEF). Increases in pulmonary capillary wedge pressure (PCWP) develop in patients with HFpEF during exercise coupled with impaired nitric oxide (NO) signaling. Nitrite can be reduced to bioactive NO in vivo,...

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Bibliographic Details
Published in:	Journal of the American College of Cardiology Vol. 66; no. 15; p. 1672
Main Authors:	Borlaug, Barry A, Koepp, Katlyn E, Melenovsky, Vojtech
Format:	Journal Article
Language:	English
Published:	United States 13.10.2015
Subjects:	Aged Cardiac Catheterization Double-Blind Method Exercise Test Exercise Tolerance - drug effects Exercise Tolerance - physiology Female Heart Failure - diagnosis Heart Failure - drug therapy Heart Failure - physiopathology Heart Ventricles - physiopathology Humans Male Prospective Studies Sodium Nitrite - therapeutic use Stroke Volume - drug effects Ventricular Function, Left - drug effects Ventricular Function, Left - physiology cardiac output nitrate pressure stroke volume
ISSN:	1558-3597, 1558-3597
Online Access:	Get more information
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