Histone deacetylases (HDAC) in physiological and pathological bone remodelling

Histone deacetylases (HDACs)22Histone deacetylases (HDACs). play important roles in the epigenetic regulation of gene expression in cells and are emerging therapeutic targets for treating a wide range of diseases. HDAC inhibitors (HDACi)33HDAC inhibitors (HDACi). that act on multiple HDAC enzymes ha...

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Vydáno v:	Bone (New York, N.Y.) Ročník 95; s. 162 - 174
Hlavní autoři:	Cantley, M.D., Zannettino, A.C.W., Bartold, P.M., Fairlie, D.P., Haynes, D.R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.02.2017
Témata:	Animals Bone Remodeling - physiology Cell Differentiation - drug effects Histone Deacetylase Inhibitors - pharmacology Histone deacetylases (HDAC) Histone Deacetylases - metabolism Humans Myeloma bone disease Orthopedics Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Osteoclasts Osteoclasts - drug effects Osteoclasts - metabolism Periodontitis Rheumatoid arthritis RANKL Histone deacetylases (HDAC) CTCL PTH ALP NFATc1 TRAP Osteoblasts Myeloma bone disease RASFs shRNA SOST HDACi MM SAHA TSA BMM siRNA RA BMPs Periodontitis TNF-α TRAF-6 Rheumatoid arthritis Osteoclasts HDAC trichostatin A cutaneous T-cell lymphoma small interfering RNA tumour necrosis factor (TNF) receptor associated factor-6 short hairpin RNA alkaline phosphatase tumour necrosis factor alpha bone marrow macrophages histone deacetylase inhibitors bone morphogenetic proteins parathyroid hormone multiple myeloma receptor activator of nuclear factor kappa B ligand histone deacetylase rheumatoid arthritis synovial fibroblasts nuclear factor of activated T cells sclerostin tartrate resistant acid phosphatase suberanilohydroxamic acid
ISSN:	8756-3282, 1873-2763, 1873-2763
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