Directed phenotype switching as an effective antimelanoma strategy

Therapeutic resistance in melanoma and other cancers arises via irreversible genetic, and dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in melanoma to sensitize melanoma cells to lineage-specific therapy. We show that methotrexate (MTX) induces microphthalmia-associate...

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Veröffentlicht in:	Cancer cell Jg. 24; H. 1; S. 105
Hauptverfasser:	Sáez-Ayala, Magalí, Montenegro, María F, Sánchez-Del-Campo, Luis, Fernández-Pérez, María Piedad, Chazarra, Soledad, Freter, Rasmus, Middleton, Mark, Piñero-Madrona, Antonio, Cabezas-Herrera, Juan, Goding, Colin R, Rodríguez-López, José Neptuno
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 08.07.2013
Schlagworte:	Apoptosis - drug effects Catechin - analogs & derivatives Catechin - pharmacology Cell Differentiation - drug effects Cell Line, Tumor DNA Damage E2F1 Transcription Factor - physiology Humans Melanoma - drug therapy Melanoma - pathology Methotrexate - pharmacology Microphthalmia-Associated Transcription Factor - genetics Phenotype Thymine Nucleotides - metabolism
ISSN:	1878-3686, 1878-3686
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