Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis

Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process. OPN and miR-21 were significantly increased in cardiac biopsies...

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Vydáno v:	European heart journal Ročník 36; číslo 32; s. 2184
Hlavní autoři:	Lorenzen, Johan M, Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K, Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A, Weidemann, Frank, Müller, Oliver J, Haller, Hermann, Thum, Thomas
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 21.08.2015
Témata:	Adenoviridae Aged Angiotensin II - physiology Animals Cell Survival Cells, Cultured Collagen - metabolism Female Fibrosis - genetics Gene Silencing Genetic Vectors - administration & dosage Humans In Vitro Techniques Male Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism Myocardium - pathology Myofibroblasts - physiology Osteopontin - pharmacology Osteopontin - physiology Phosphatidylinositol 3-Kinases - metabolism PTEN Phosphohydrolase - metabolism Recombinant Proteins - pharmacology Transcription Factors Osteopontin Cardiac fibrosis microRNA miR-21 Angiotensin II
ISSN:	1522-9645, 1522-9645
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