Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis

Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process. OPN and miR-21 were significantly increased in cardiac biopsies...

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Bibliographic Details
Published in:	European heart journal Vol. 36; no. 32; p. 2184
Main Authors:	Lorenzen, Johan M, Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K, Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A, Weidemann, Frank, Müller, Oliver J, Haller, Hermann, Thum, Thomas
Format:	Journal Article
Language:	English
Published:	England 21.08.2015
Subjects:	Adenoviridae Aged Angiotensin II - physiology Animals Cell Survival Cells, Cultured Collagen - metabolism Female Fibrosis - genetics Gene Silencing Genetic Vectors - administration & dosage Humans In Vitro Techniques Male Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism Myocardium - pathology Myofibroblasts - physiology Osteopontin - pharmacology Osteopontin - physiology Phosphatidylinositol 3-Kinases - metabolism PTEN Phosphohydrolase - metabolism Recombinant Proteins - pharmacology Transcription Factors Osteopontin Cardiac fibrosis microRNA miR-21 Angiotensin II
ISSN:	1522-9645, 1522-9645
Online Access:	Get more information
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