The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling

Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require it...

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Bibliographic Details
Published in:	FEBS letters Vol. 584; no. 9; pp. 1923 - 1930
Main Authors:	Blasi, Francesco, Sidenius, Nicolai
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 03.05.2010
Subjects:	Animals Cell Adhesion Cell migration Cell proliferation Humans Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Models, Molecular Molecular Conformation Protein Binding - physiology Protein Processing, Post-Translational Receptors, Urokinase Plasminogen Activator - chemistry Receptors, Urokinase Plasminogen Activator - metabolism Receptors, Urokinase Plasminogen Activator - physiology Signal Transduction - physiology Signaling Urokinase receptor uPAR Cell proliferation Signaling Urokinase receptor uPAR Cell migration Cell adhesion
ISSN:	0014-5793, 1873-3468, 1873-3468
Online Access:	Get full text
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