The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling

Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require it...

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Bibliographic Details
Published in:FEBS letters Vol. 584; no. 9; pp. 1923 - 1930
Main Authors: Blasi, Francesco, Sidenius, Nicolai
Format: Journal Article
Language:English
Published: England Elsevier B.V 03.05.2010
Subjects:
Animals
Cell Adhesion
Cell migration
Cell proliferation
Humans
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - metabolism
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Models, Molecular
Molecular Conformation
Protein Binding - physiology
Protein Processing, Post-Translational
Receptors, Urokinase Plasminogen Activator - chemistry
Receptors, Urokinase Plasminogen Activator - metabolism
Receptors, Urokinase Plasminogen Activator - physiology
Signal Transduction - physiology
Signaling
Urokinase receptor uPAR
Cell proliferation
Signaling
Urokinase receptor uPAR
Cell migration
Cell adhesion
ISSN:0014-5793, 1873-3468, 1873-3468
Online Access:Get full text
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Abstract Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require its protease ligand or its proteolytic function. uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over-expression of components of the uPA/uPAR-system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.
AbstractList uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over‐expression of components of the uPA/uPAR‐system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.
Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require its protease ligand or its proteolytic function. uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over-expression of components of the uPA/uPAR-system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells-extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.
Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require its protease ligand or its proteolytic function. uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over-expression of components of the uPA/uPAR-system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells-extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require its protease ligand or its proteolytic function. uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over-expression of components of the uPA/uPAR-system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells-extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.
Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require its protease ligand or its proteolytic function. uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over-expression of components of the uPA/uPAR-system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.
Author Blasi, Francesco
Sidenius, Nicolai
Author_xml – sequence: 1
  givenname: Francesco
  surname: Blasi
  fullname: Blasi, Francesco
  email: Francesco.blasi@ifom-ieo-campus.it
  organization: Università Vita Salute San Raffaele, via Olgettina 60, 20132 Milano, Italy
– sequence: 2
  givenname: Nicolai
  surname: Sidenius
  fullname: Sidenius, Nicolai
  email: nicolai.sidenius@ifom-ieo-campus.it
  organization: Unit of Cell Matrix Signaling, IFOM (Fondazione Istituto FIRC di Oncologia Molecolare), IFOM-IEO-Campus, Via Adamello 16, 20139 Milano, Italy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20036661$$D View this record in MEDLINE/PubMed
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Copyright 2009 Federation of European Biochemical Societies
FEBS Letters 584 (2010) 1873-3468 © 2015 Federation of European Biochemical Societies
Copyright 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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– notice: FEBS Letters 584 (2010) 1873-3468 © 2015 Federation of European Biochemical Societies
– notice: Copyright 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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Issue 9
Keywords Cell proliferation
Signaling
Urokinase receptor uPAR
Cell migration
Cell adhesion
Language English
License http://www.elsevier.com/open-access/userlicense/1.0
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Copyright 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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Snippet Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine...
uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as...
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wiley
elsevier
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StartPage 1923
SubjectTerms Animals
Cell Adhesion
Cell migration
Cell proliferation
Humans
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - metabolism
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Models, Molecular
Molecular Conformation
Protein Binding - physiology
Protein Processing, Post-Translational
Receptors, Urokinase Plasminogen Activator - chemistry
Receptors, Urokinase Plasminogen Activator - metabolism
Receptors, Urokinase Plasminogen Activator - physiology
Signal Transduction - physiology
Signaling
Urokinase receptor uPAR
Title The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling
URI https://dx.doi.org/10.1016/j.febslet.2009.12.039
https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.febslet.2009.12.039
https://www.ncbi.nlm.nih.gov/pubmed/20036661
https://www.proquest.com/docview/733592222
Volume 584
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