Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Bi-directional Mendelian randomization (MR) analysis on prospe...
Uložené v:
| Vydané v: | PloS one Ročník 12; číslo 4; s. e0176277 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
Public Library of Science
2017
Public Library of Science (PLoS) |
| Predmet: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.
Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.
Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.
Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).
7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.
BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.
1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).
Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. |
|---|---|
| AbstractList | Context
Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.
Objectives
Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.
Design
Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.
Setting
Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).
Participants
7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.
Main outcome measures
BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.
Results
1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42–-0.09, p = 2.8*10−3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).
Conclusions
Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Design Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Setting Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). Participants 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. Main outcome measures BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. Results 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42–-0.09, p = 2.8*10−3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). Conclusions Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden). 7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs. BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site. 1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42-0.09, p = 2.8*10(-3)). For a body weight reduction altering the BMI from 30 to 25 kg/m(2), the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349). Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.CONTEXTObesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.OBJECTIVESExamine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.DESIGNBi-directional Mendelian randomization (MR) analysis on prospective cohorts.Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).SETTINGFive cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.PARTICIPANTS7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.MAIN OUTCOME MEASURESBMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).RESULTS1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42--0.09, p = 2.8*10-3). For a body weight reduction altering the BMI from 30 to 25 kg/m2, the effect would equal a 13% increase in serum testosterone. No association was seen for genetically instrumented testosterone with BMI, a finding that was confirmed using large-scale data from the GIANT consortium (n = 104349).Our results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men.CONCLUSIONSOur results suggest that there is a causal effect of BMI on serum testosterone in men. Population level interventions to reduce BMI are expected to increase serum testosterone in men. |
| Author | Grarup, Niels Völzke, Henry Lorentzon, Mattias Karlsson, Magnus Haring, Robin Lorentzen, Erik Pedersen, Oluf Linneberg, Allan Hansen, Torben Eriksson, Joel Vandenput, Liesbeth Ohlsson, Claes Nystrup Husemoen, Lise Lotte Nauck, Matthias Wallaschofski, Henri Mellström, Dan Baumeister, Sebastian E. |
| AuthorAffiliation | 1 Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 8 University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany 3 School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia 6 Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden 2 University Medicine Greifswald, Institute of Clinical Chemistry and Laboratory Medicine, Greifswald, Germany Shanghai Diabetes Institute, CHINA 10 Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany 9 Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics and Clinical Sciences, Lund University, Skåne University Hospital (SUS), Malmö, Sweden 4 The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copen |
| AuthorAffiliation_xml | – name: 8 University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany – name: 5 Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden – name: 3 School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia – name: 12 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark – name: 2 University Medicine Greifswald, Institute of Clinical Chemistry and Laboratory Medicine, Greifswald, Germany – name: 4 The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark – name: Shanghai Diabetes Institute, CHINA – name: 10 Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany – name: 1 Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden – name: 6 Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden – name: 7 Research Centre for Prevention and Health, the Capital Region, Copenhagen, Denmark – name: 9 Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics and Clinical Sciences, Lund University, Skåne University Hospital (SUS), Malmö, Sweden – name: 11 Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark |
| Author_xml | – sequence: 1 givenname: Joel surname: Eriksson fullname: Eriksson, Joel – sequence: 2 givenname: Robin surname: Haring fullname: Haring, Robin – sequence: 3 givenname: Niels surname: Grarup fullname: Grarup, Niels – sequence: 4 givenname: Liesbeth surname: Vandenput fullname: Vandenput, Liesbeth – sequence: 5 givenname: Henri surname: Wallaschofski fullname: Wallaschofski, Henri – sequence: 6 givenname: Erik surname: Lorentzen fullname: Lorentzen, Erik – sequence: 7 givenname: Torben surname: Hansen fullname: Hansen, Torben – sequence: 8 givenname: Dan surname: Mellström fullname: Mellström, Dan – sequence: 9 givenname: Oluf surname: Pedersen fullname: Pedersen, Oluf – sequence: 10 givenname: Matthias surname: Nauck fullname: Nauck, Matthias – sequence: 11 givenname: Mattias surname: Lorentzon fullname: Lorentzon, Mattias – sequence: 12 givenname: Lise Lotte surname: Nystrup Husemoen fullname: Nystrup Husemoen, Lise Lotte – sequence: 13 givenname: Henry surname: Völzke fullname: Völzke, Henry – sequence: 14 givenname: Magnus surname: Karlsson fullname: Karlsson, Magnus – sequence: 15 givenname: Sebastian E. surname: Baumeister fullname: Baumeister, Sebastian E. – sequence: 16 givenname: Allan surname: Linneberg fullname: Linneberg, Allan – sequence: 17 givenname: Claes surname: Ohlsson fullname: Ohlsson, Claes |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28448539$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/254175$$DView record from Swedish Publication Index (Göteborgs universitet) |
| BookMark | eNp9kk1v1DAQhiNURNuFf4DAEhcuWZzYieMekKqKj0qVuMDZmiSTrVeOHWyHauHP4_1o1a0Qp0STd555Z_KeZyfWWcyy1wVdFkwUH9Zu9hbMckrlJS1EXQrxLDsrJCvzuqTs5NH7aXYewprSijV1_SI7LRvOm4rJs-zPFcwBDPFoIGpnw62eSIvxDtES12LQcUPA9iSgn0cSMUQXIvo0lIQIcQ5EWzKivSCXpNV5rz12W1BipmqPRoMlPhHcqH_vRiQcmE3Q4WX2fAAT8NXhuch-fP70_eprfvPty_XV5U3ecclj3g9l05ZV1VQ91APFsoa-pm0LaZmGt3038EbCwIaiQgEAQw-VoLRgrMBaCsoW2ds9dzIuqMPdgiqkpJQKma6yyK73it7BWk1ej-A3yoFWu4LzKwU-6s6g4tiUsuesrpngouxBSs6TubKFDqBiiZXvWeEOp7k9oq3mSaXSalYBVVnxQmxnfzy4m9sR-w5t9GCO2o6_WH2rVu6XqjgVDRUJ8P4A8O7nnH6QGnXo0Biw6Oa0ZyNZlYwV21nvnkj_fY03jx09WLlPTRLwvaDzLgSPw4OkoGobznus2oZTHcKZ2i6etHU67iKR9tLm_81_AV_A8VQ |
| CitedBy_id | crossref_primary_10_1111_joim_13509 crossref_primary_10_1111_cen_14342 crossref_primary_10_2147_DMSO_S293259 crossref_primary_10_3390_cancers15225364 crossref_primary_10_1111_obr_13429 crossref_primary_10_1177_15598276241242012 crossref_primary_10_1111_and_13731 crossref_primary_10_1016_j_acuro_2019_10_009 crossref_primary_10_1089_andro_2020_0010 crossref_primary_10_3389_fendo_2021_735638 crossref_primary_10_3390_children6050063 crossref_primary_10_1016_j_steroids_2025_109615 crossref_primary_10_1016_j_metabol_2022_155342 crossref_primary_10_1007_s11695_024_07075_x crossref_primary_10_1038_s43856_022_00226_0 crossref_primary_10_3389_fendo_2023_1230279 crossref_primary_10_1186_s13293_021_00388_x crossref_primary_10_1007_s10654_023_00986_6 crossref_primary_10_1373_clinchem_2018_289355 crossref_primary_10_1089_met_2018_0050 crossref_primary_10_1016_j_beem_2022_101622 crossref_primary_10_1016_j_jse_2019_12_031 crossref_primary_10_1136_bmj_l476 crossref_primary_10_1111_andr_12705 crossref_primary_10_1111_cen_13723 crossref_primary_10_1371_journal_pone_0189042 crossref_primary_10_1111_obr_12863 crossref_primary_10_1210_clinem_dgac236 crossref_primary_10_1530_JOE_18_0673 crossref_primary_10_1002_art_42613 crossref_primary_10_1186_s12916_021_02188_x crossref_primary_10_3389_fendo_2022_960222 crossref_primary_10_1016_j_jse_2019_08_008 crossref_primary_10_1007_s00787_024_02421_x crossref_primary_10_1093_hmg_ddac186 crossref_primary_10_1177_1753193420958553 crossref_primary_10_7554_eLife_58567 crossref_primary_10_1007_s11154_022_09746_5 crossref_primary_10_1016_j_acuroe_2019_10_008 crossref_primary_10_1186_s12944_025_02436_6 crossref_primary_10_1016_j_beem_2022_101654 crossref_primary_10_31083_IJVNR26559 crossref_primary_10_3390_nu10111786 crossref_primary_10_1038_s41443_022_00555_7 crossref_primary_10_1111_and_13035 crossref_primary_10_14814_phy2_15127 crossref_primary_10_1016_j_envres_2024_120054 crossref_primary_10_4103_aja202212 crossref_primary_10_1007_s40619_025_01624_x crossref_primary_10_1038_s41431_020_00712_w crossref_primary_10_1007_s13629_018_0235_2 crossref_primary_10_1016_j_metabol_2022_155326 crossref_primary_10_1186_s43162_024_00358_w crossref_primary_10_1016_j_socscimed_2018_11_004 crossref_primary_10_1042_BCJ20180631 crossref_primary_10_1016_j_ijcard_2021_06_037 crossref_primary_10_1038_s41598_022_07344_8 crossref_primary_10_1002_ijc_31375 crossref_primary_10_1111_cen_13862 crossref_primary_10_3390_cancers15194884 crossref_primary_10_3390_ijerph16193759 crossref_primary_10_1186_s12902_022_01102_7 |
| Cites_doi | 10.1373/clinchem.2008.105841 10.1530/EJE-12-0955 10.1053/euhj.1999.1873 10.1007/s12263-010-0181-y 10.1210/jc.2007-1972 10.1177/2047487312452965 10.1001/jama.288.18.2282 10.1093/oxfordjournals.aje.a008832 10.1371/journal.pgen.1002313 10.1002/gepi.20552 10.1016/j.jacc.2011.07.019 10.1210/jc.2006-1859 10.1001/jama.2013.280386 10.5694/mja13.10111 10.1210/jc.2006-2633 10.1186/1741-7015-9-71 10.1210/jc.2004-1933 10.1126/science.1141634 10.1371/journal.pgen.0030115 10.1210/jc.2015-3505 10.1093/ije/dyt110 10.1038/ng.714 10.1210/jc.2009-1251 10.1056/NEJMp1506632 10.1002/sim.3034 10.1038/sj.ijo.0802964 10.1210/jc.2004-0970 10.1038/ng.140 10.1111/cen.12103 10.1093/gerona/56.5.M266 10.2174/157339912799424573 10.1159/000299767 10.2164/jandrol.108.005561 10.3109/13685538.2010.487553 10.1093/ije/dyh132 10.4093/dmj.2014.38.4.302 10.1016/j.mce.2009.06.007 10.1359/JBMR.050404 10.1038/nature14177 10.1371/journal.pmed.1001383 10.1530/EJE-11-0221 10.1210/jc.2009-2354 10.1359/jbmr.061018 10.1210/jc.2010-2724 10.1136/bmj.g6330 10.1056/NEJMoa1000485 |
| ContentType | Journal Article |
| Copyright | 2017 Eriksson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Eriksson et al 2017 Eriksson et al |
| Copyright_xml | – notice: 2017 Eriksson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Eriksson et al 2017 Eriksson et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM ADTPV AOWAS F1U DOA |
| DOI | 10.1371/journal.pone.0176277 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest SciTech Premium Collection Technology Collection Materials Science & Engineering Database ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Local Electronic Collection Information Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Göteborgs universitet DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Obesity and serum testosterone in men |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1990007905 oai_doaj_org_article_4e829d436637472da99445582bacaa53 oai_gup_ub_gu_se_254175 PMC5407807 28448539 10_1371_journal_pone_0176277 |
| Genre | Journal Article |
| GeographicLocations | Denmark Sweden Germany |
| GeographicLocations_xml | – name: Denmark – name: Germany – name: Sweden |
| GrantInformation_xml | – fundername: ; grantid: 2011-2535 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM ADTPV AOWAS F1U - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c494t-df28b25585da6f0e26ad60bba38684bdcf489af3f15e7aaafda57001331e69703 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 71 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000400383600055&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 18:09:38 EST 2021 Tue Oct 14 19:04:28 EDT 2025 Tue Nov 04 16:47:51 EST 2025 Tue Nov 04 01:50:08 EST 2025 Sun Nov 09 09:04:49 EST 2025 Tue Oct 07 09:15:59 EDT 2025 Wed Feb 19 02:16:22 EST 2025 Sat Nov 29 03:25:49 EST 2025 Tue Nov 18 22:17:29 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c494t-df28b25585da6f0e26ad60bba38684bdcf489af3f15e7aaafda57001331e69703 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: JE RH AL CO.Data curation: JE RH AL CO.Formal analysis: JE RH NG LV HW EL TH DM OP MN ML LLNH HV MK SEB AL CO.Funding acquisition: RH AL CO.Investigation: JE EL CO.Methodology: JE RH LV AL CO.Project administration: JE RH AL CO.Resources: JE RH LV AL CO.Software: JE EL.Supervision: JE RH AL CO.Validation: JE RH AL CO.Visualization: JE RH AL CO.Writing – original draft: JE RH LV AL CO.Writing – review & editing: JE RH NG LV HW EL TH DM OP MN ML LLNH HV MK SEB AL CO. |
| OpenAccessLink | https://doaj.org/article/4e829d436637472da99445582bacaa53 |
| PMID | 28448539 |
| PQID | 1990007905 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1990007905 doaj_primary_oai_doaj_org_article_4e829d436637472da99445582bacaa53 swepub_primary_oai_gup_ub_gu_se_254175 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5407807 proquest_miscellaneous_1893553315 proquest_journals_1990007905 pubmed_primary_28448539 crossref_primary_10_1371_journal_pone_0176277 crossref_citationtrail_10_1371_journal_pone_0176277 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2017 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | DJ Handelsman (ref19) 2013; 199 J Zheng (ref50) 2011; 35 DA Lawlor (ref27) 2008; 27 G Davey Smith (ref32) 2011; 6 FC Wu (ref1) 2008; 93 GD Smith (ref31) 2004; 33 S Afzal (ref30) 2014; 349 RJ Loos (ref36) 2008; 40 TG Travison (ref10) 2007; 92 KM English (ref12) 2000; 21 AM Andersson (ref25) 2007; 92 S Peng (ref45) 2011; 9 G Freeman (ref29) 2013; 42 C Ohlsson (ref18) 2011; 7 CP Nguyen (ref16) 2015; 373 PJ Snyder (ref5) 1999; 84 DE Laaksonen (ref9) 2005; 90 C Ohlsson (ref13) 2011; 58 S Bhasin (ref48) 2010; 95 A Scuteri (ref35) 2007; 3 VA Giagulli (ref39) 1994; 79 JT George (ref43) 2010; 91 JT George (ref44) 2013; 79 M Lorentzon (ref23) 2005; 20 K Song do (ref47) 2014; 38 A Vermeulen (ref40) 1993; 76 ST Page (ref4) 2005; 90 R Vigen (ref15) 2013; 310 P Dandona (ref38) 2011; 96 TM Frayling (ref34) 2007; 316 AM Kenny (ref3) 2001; 56 J Rice (ref26) 1995 R Haring (ref24) 2013; 20 S Basaria (ref14) 2010; 363 F Saad (ref7) 2012; 8 N Friedrich (ref21) 2008; 29 CE Elks (ref46) 2010; 42 R Haring (ref8) 2010; 13 F Saad (ref41) 2011; 165 C Berg (ref49) 2005; 29 L Vandenput (ref20) 2007; 22 PN Taylor (ref33) 2016; 101 KS Vimaleswaran (ref28) 2013; 10 LM Thienpont (ref22) 2008; 54 MR Blackman (ref2) 2002; 288 G Corona (ref37) 2013; 168 PM Mah (ref42) 2010; 316 AE Locke (ref17) 2015; 518 U Srinivas-Shankar (ref6) 2010; 95 SM Haffner (ref11) 1996; 143 10443654 - J Clin Endocrinol Metab. 1999 Aug;84(8):2647-53 20061435 - J Clin Endocrinol Metab. 2010 Feb;95(2):639-50 18599883 - J Androl. 2008 Nov-Dec;29(6):610-7 23393431 - PLoS Med. 2013;10(2):e1001383 8610702 - Am J Epidemiol. 1996 May 1;143(9):889-97 21651756 - BMC Med. 2011 Jun 08;9:71 21254217 - Genet Epidemiol. 2011 Feb;35(2):102-10 21982312 - J Am Coll Cardiol. 2011 Oct 11;58(16):1674-81 26287846 - N Engl J Med. 2015 Aug 20;373(8):689-91 17148559 - J Clin Endocrinol Metab. 2007 Feb;92(2):549-55 23153270 - Clin Endocrinol (Oxf). 2013 Jul;79(1):100-4 18556330 - Clin Chem. 2008 Aug;54(8):1290-7 16007330 - J Bone Miner Res. 2005 Aug;20(8):1334-41 18454148 - Nat Genet. 2008 Jun;40(6):768-75 26595101 - J Clin Endocrinol Metab. 2016 Feb;101(2):730-8 21102462 - Nat Genet. 2010 Dec;42(12):1077-85 8496304 - J Clin Endocrinol Metab. 1993 May;76(5):1140-6 12425705 - JAMA. 2002 Nov 13;288(18):2282-92 21437028 - Genes Nutr. 2011 Feb;6(1):27-43 17434869 - Science. 2007 May 11;316(5826):889-94 23482592 - Eur J Endocrinol. 2013 May 02;168(6):829-43 21753068 - Eur J Endocrinol. 2011 Nov;165(5):675-85 24193080 - JAMA. 2013 Nov 6;310(17):1829-36 24138381 - Med J Aust. 2013 Oct 21;199(8):548-51 25406188 - BMJ. 2014 Nov 18;349:g6330 22711969 - Eur J Prev Cardiol. 2013 Dec;20(6):1061-8 15852045 - Int J Obes (Lond). 2005 Aug;29(8):916-24 22268394 - Curr Diabetes Rev. 2012 Mar;8(2):131-43 20592293 - N Engl J Med. 2010 Jul 8;363(2):109-22 15536158 - J Clin Endocrinol Metab. 2005 Feb;90(2):712-9 17658951 - PLoS Genet. 2007 Jul;3(7):e115 20504090 - Aging Male. 2010 Dec;13(4):247-57 11320105 - J Gerontol A Biol Sci Med Sci. 2001 May;56(5):M266-72 17895324 - J Clin Endocrinol Metab. 2007 Dec;92(12):4696-705 20525905 - J Clin Endocrinol Metab. 2010 Jun;95(6):2536-59 10806012 - Eur Heart J. 2000 Jun;21(11):890-4 21896895 - J Clin Endocrinol Metab. 2011 Sep;96(9):2643-51 15572415 - J Clin Endocrinol Metab. 2005 Mar;90(3):1502-10 7962311 - J Clin Endocrinol Metab. 1994 Oct;79(4):997-1000 23934314 - Int J Epidemiol. 2013 Aug;42(4):1157-63 19540307 - Mol Cell Endocrinol. 2010 Mar 25;316(2):180-6 20628262 - Neuroendocrinology. 2010;91(4):302-7 25673413 - Nature. 2015 Feb 12;518(7538):197-206 17059374 - J Bone Miner Res. 2007 Feb;22(2):220-7 18270261 - J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45 25215277 - Diabetes Metab J. 2014 Aug;38(4):302-10 15075143 - Int J Epidemiol. 2004 Feb;33(1):30-42 21998597 - PLoS Genet. 2011 Oct;7(10):e1002313 17886233 - Stat Med. 2008 Apr 15;27(8):1133-63 |
| References_xml | – volume: 54 start-page: 1290 issue: 8 year: 2008 ident: ref22 article-title: State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry publication-title: Clin Chem doi: 10.1373/clinchem.2008.105841 – year: 1995 ident: ref26 article-title: Mathematical Statistics and Data Analysis – volume: 168 start-page: 829 issue: 6 year: 2013 ident: ref37 article-title: Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis publication-title: European journal of endocrinology / European Federation of Endocrine Societies doi: 10.1530/EJE-12-0955 – volume: 21 start-page: 890 issue: 11 year: 2000 ident: ref12 article-title: Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms publication-title: Eur Heart J doi: 10.1053/euhj.1999.1873 – volume: 6 start-page: 27 issue: 1 year: 2011 ident: ref32 article-title: Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health publication-title: Genes Nutr doi: 10.1007/s12263-010-0181-y – volume: 93 start-page: 2737 issue: 7 year: 2008 ident: ref1 article-title: Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2007-1972 – volume: 20 start-page: 1061 issue: 6 year: 2013 ident: ref24 article-title: The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome publication-title: Eur J Prev Cardiol doi: 10.1177/2047487312452965 – volume: 288 start-page: 2282 issue: 18 year: 2002 ident: ref2 article-title: Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial publication-title: Jama doi: 10.1001/jama.288.18.2282 – volume: 143 start-page: 889 issue: 9 year: 1996 ident: ref11 article-title: Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a008832 – volume: 7 start-page: e1002313 issue: 10 year: 2011 ident: ref18 article-title: Genetic determinants of serum testosterone concentrations in men publication-title: PLoS genetics doi: 10.1371/journal.pgen.1002313 – volume: 35 start-page: 102 issue: 2 year: 2011 ident: ref50 article-title: A comparison of approaches to account for uncertainty in analysis of imputed genotypes publication-title: Genet Epidemiol doi: 10.1002/gepi.20552 – volume: 58 start-page: 1674 issue: 16 year: 2011 ident: ref13 article-title: High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. The MrOS (Osteoporotic Fractures in Men) study in Sweden publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2011.07.019 – volume: 92 start-page: 549 issue: 2 year: 2007 ident: ref10 article-title: The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2006-1859 – volume: 310 start-page: 1829 issue: 17 year: 2013 ident: ref15 article-title: Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels publication-title: Jama doi: 10.1001/jama.2013.280386 – volume: 199 start-page: 548 issue: 8 year: 2013 ident: ref19 article-title: Global trends in testosterone prescribing, 2000–2011: expanding the spectrum of prescription drug misuse publication-title: Med J Aust doi: 10.5694/mja13.10111 – volume: 92 start-page: 4696 issue: 12 year: 2007 ident: ref25 article-title: Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2006-2633 – volume: 9 start-page: 71 year: 2011 ident: ref45 article-title: FTO gene polymorphisms and obesity risk: a meta-analysis publication-title: BMC Med doi: 10.1186/1741-7015-9-71 – volume: 90 start-page: 1502 issue: 3 year: 2005 ident: ref4 article-title: Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2004-1933 – volume: 316 start-page: 889 issue: 5826 year: 2007 ident: ref34 article-title: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity publication-title: Science doi: 10.1126/science.1141634 – volume: 3 start-page: e115 issue: 7 year: 2007 ident: ref35 article-title: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits publication-title: PLoS genetics doi: 10.1371/journal.pgen.0030115 – volume: 101 start-page: 730 issue: 2 year: 2016 ident: ref33 article-title: Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2015-3505 – volume: 42 start-page: 1157 issue: 4 year: 2013 ident: ref29 article-title: Power and sample size calculations for Mendelian randomization studies using one genetic instrument publication-title: International journal of epidemiology doi: 10.1093/ije/dyt110 – volume: 42 start-page: 1077 issue: 12 year: 2010 ident: ref46 article-title: Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies publication-title: Nat Genet doi: 10.1038/ng.714 – volume: 95 start-page: 639 issue: 2 year: 2010 ident: ref6 article-title: Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2009-1251 – volume: 373 start-page: 689 issue: 8 year: 2015 ident: ref16 article-title: Testosterone and "Age-Related Hypogonadism"—FDA Concerns publication-title: The New England journal of medicine doi: 10.1056/NEJMp1506632 – volume: 27 start-page: 1133 issue: 8 year: 2008 ident: ref27 article-title: Mendelian randomization: using genes as instruments for making causal inferences in epidemiology publication-title: Statistics in medicine doi: 10.1002/sim.3034 – volume: 29 start-page: 916 issue: 8 year: 2005 ident: ref49 article-title: Trends in overweight and obesity from 1985 to 2002 in Goteborg, West Sweden publication-title: Int J Obes (Lond) doi: 10.1038/sj.ijo.0802964 – volume: 90 start-page: 712 issue: 2 year: 2005 ident: ref9 article-title: The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2004-0970 – volume: 40 start-page: 768 issue: 6 year: 2008 ident: ref36 article-title: Common variants near MC4R are associated with fat mass, weight and risk of obesity publication-title: Nat Genet doi: 10.1038/ng.140 – volume: 79 start-page: 100 issue: 1 year: 2013 ident: ref44 article-title: Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism publication-title: Clinical endocrinology doi: 10.1111/cen.12103 – volume: 56 start-page: M266 issue: 5 year: 2001 ident: ref3 article-title: Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/56.5.M266 – volume: 8 start-page: 131 issue: 2 year: 2012 ident: ref7 article-title: Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review publication-title: Curr Diabetes Rev doi: 10.2174/157339912799424573 – volume: 79 start-page: 997 issue: 4 year: 1994 ident: ref39 article-title: Pathogenesis of the decreased androgen levels in obese men publication-title: The Journal of clinical endocrinology and metabolism – volume: 91 start-page: 302 issue: 4 year: 2010 ident: ref43 article-title: Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes publication-title: Neuroendocrinology doi: 10.1159/000299767 – volume: 29 start-page: 610 issue: 6 year: 2008 ident: ref21 article-title: Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men publication-title: J Androl doi: 10.2164/jandrol.108.005561 – volume: 13 start-page: 247 issue: 4 year: 2010 ident: ref8 article-title: Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania publication-title: The aging male: the official journal of the International Society for the Study of the Aging Male doi: 10.3109/13685538.2010.487553 – volume: 33 start-page: 30 issue: 1 year: 2004 ident: ref31 article-title: Mendelian randomization: prospects, potentials, and limitations publication-title: International journal of epidemiology doi: 10.1093/ije/dyh132 – volume: 38 start-page: 302 issue: 4 year: 2014 ident: ref47 article-title: FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women publication-title: Diabetes Metab J doi: 10.4093/dmj.2014.38.4.302 – volume: 316 start-page: 180 issue: 2 year: 2010 ident: ref42 article-title: Obesity and testicular function publication-title: Molecular and cellular endocrinology doi: 10.1016/j.mce.2009.06.007 – volume: 84 start-page: 2647 issue: 8 year: 1999 ident: ref5 article-title: Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age publication-title: The Journal of clinical endocrinology and metabolism – volume: 20 start-page: 1334 issue: 8 year: 2005 ident: ref23 article-title: Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study publication-title: J Bone Miner Res doi: 10.1359/JBMR.050404 – volume: 518 start-page: 197 issue: 7538 year: 2015 ident: ref17 article-title: Genetic studies of body mass index yield new insights for obesity biology publication-title: Nature doi: 10.1038/nature14177 – volume: 10 start-page: e1001383 issue: 2 year: 2013 ident: ref28 article-title: Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts publication-title: PLoS medicine doi: 10.1371/journal.pmed.1001383 – volume: 76 start-page: 1140 issue: 5 year: 1993 ident: ref40 article-title: Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men publication-title: The Journal of clinical endocrinology and metabolism – volume: 165 start-page: 675 issue: 5 year: 2011 ident: ref41 article-title: Onset of effects of testosterone treatment and time span until maximum effects are achieved publication-title: European journal of endocrinology / European Federation of Endocrine Societies doi: 10.1530/EJE-11-0221 – volume: 95 start-page: 2536 issue: 6 year: 2010 ident: ref48 article-title: Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2009-2354 – volume: 22 start-page: 220 issue: 2 year: 2007 ident: ref20 article-title: Serum levels of specific glucuronidated androgen metabolites predict BMD and prostate volume in elderly men publication-title: J Bone Miner Res doi: 10.1359/jbmr.061018 – volume: 96 start-page: 2643 issue: 9 year: 2011 ident: ref38 article-title: Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity publication-title: The Journal of clinical endocrinology and metabolism doi: 10.1210/jc.2010-2724 – volume: 349 start-page: g6330 year: 2014 ident: ref30 article-title: Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts publication-title: BMJ doi: 10.1136/bmj.g6330 – volume: 363 start-page: 109 issue: 2 year: 2010 ident: ref14 article-title: Adverse events associated with testosterone administration publication-title: The New England journal of medicine doi: 10.1056/NEJMoa1000485 – reference: 21753068 - Eur J Endocrinol. 2011 Nov;165(5):675-85 – reference: 24138381 - Med J Aust. 2013 Oct 21;199(8):548-51 – reference: 15852045 - Int J Obes (Lond). 2005 Aug;29(8):916-24 – reference: 8496304 - J Clin Endocrinol Metab. 1993 May;76(5):1140-6 – reference: 22268394 - Curr Diabetes Rev. 2012 Mar;8(2):131-43 – reference: 18454148 - Nat Genet. 2008 Jun;40(6):768-75 – reference: 25673413 - Nature. 2015 Feb 12;518(7538):197-206 – reference: 23934314 - Int J Epidemiol. 2013 Aug;42(4):1157-63 – reference: 20525905 - J Clin Endocrinol Metab. 2010 Jun;95(6):2536-59 – reference: 17895324 - J Clin Endocrinol Metab. 2007 Dec;92(12):4696-705 – reference: 8610702 - Am J Epidemiol. 1996 May 1;143(9):889-97 – reference: 22711969 - Eur J Prev Cardiol. 2013 Dec;20(6):1061-8 – reference: 15572415 - J Clin Endocrinol Metab. 2005 Mar;90(3):1502-10 – reference: 20592293 - N Engl J Med. 2010 Jul 8;363(2):109-22 – reference: 25406188 - BMJ. 2014 Nov 18;349:g6330 – reference: 15536158 - J Clin Endocrinol Metab. 2005 Feb;90(2):712-9 – reference: 21896895 - J Clin Endocrinol Metab. 2011 Sep;96(9):2643-51 – reference: 20504090 - Aging Male. 2010 Dec;13(4):247-57 – reference: 17059374 - J Bone Miner Res. 2007 Feb;22(2):220-7 – reference: 21102462 - Nat Genet. 2010 Dec;42(12):1077-85 – reference: 11320105 - J Gerontol A Biol Sci Med Sci. 2001 May;56(5):M266-72 – reference: 20061435 - J Clin Endocrinol Metab. 2010 Feb;95(2):639-50 – reference: 18599883 - J Androl. 2008 Nov-Dec;29(6):610-7 – reference: 21437028 - Genes Nutr. 2011 Feb;6(1):27-43 – reference: 23482592 - Eur J Endocrinol. 2013 May 02;168(6):829-43 – reference: 10443654 - J Clin Endocrinol Metab. 1999 Aug;84(8):2647-53 – reference: 10806012 - Eur Heart J. 2000 Jun;21(11):890-4 – reference: 21254217 - Genet Epidemiol. 2011 Feb;35(2):102-10 – reference: 26595101 - J Clin Endocrinol Metab. 2016 Feb;101(2):730-8 – reference: 21998597 - PLoS Genet. 2011 Oct;7(10):e1002313 – reference: 21651756 - BMC Med. 2011 Jun 08;9:71 – reference: 18556330 - Clin Chem. 2008 Aug;54(8):1290-7 – reference: 19540307 - Mol Cell Endocrinol. 2010 Mar 25;316(2):180-6 – reference: 17434869 - Science. 2007 May 11;316(5826):889-94 – reference: 16007330 - J Bone Miner Res. 2005 Aug;20(8):1334-41 – reference: 17886233 - Stat Med. 2008 Apr 15;27(8):1133-63 – reference: 25215277 - Diabetes Metab J. 2014 Aug;38(4):302-10 – reference: 24193080 - JAMA. 2013 Nov 6;310(17):1829-36 – reference: 23393431 - PLoS Med. 2013;10(2):e1001383 – reference: 23153270 - Clin Endocrinol (Oxf). 2013 Jul;79(1):100-4 – reference: 18270261 - J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45 – reference: 7962311 - J Clin Endocrinol Metab. 1994 Oct;79(4):997-1000 – reference: 17658951 - PLoS Genet. 2007 Jul;3(7):e115 – reference: 26287846 - N Engl J Med. 2015 Aug 20;373(8):689-91 – reference: 21982312 - J Am Coll Cardiol. 2011 Oct 11;58(16):1674-81 – reference: 17148559 - J Clin Endocrinol Metab. 2007 Feb;92(2):549-55 – reference: 15075143 - Int J Epidemiol. 2004 Feb;33(1):30-42 – reference: 20628262 - Neuroendocrinology. 2010;91(4):302-7 – reference: 12425705 - JAMA. 2002 Nov 13;288(18):2282-92 |
| SSID | ssj0053866 |
| Score | 2.476742 |
| Snippet | Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.
Examine the direction and... Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the... Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.CONTEXTObesity in men is... Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Examine the direction... Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.Examine the direction and... Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the... |
| SourceID | plos doaj swepub pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0176277 |
| SubjectTerms | Adolescent Adult Aged Androgens Biology and Life Sciences Body mass Body Mass Index Body size Body weight Clinical Medicine Consortia elderly-men fto gene Genetic Predisposition to Disease genome-wide association hormone-binding globulin Humans hypogonadotropic hypogonadism Klinisk medicin Male Medicine and Health Sciences Men Mendelian Randomization Analysis Meta-analysis metabolic syndrome muscle strength Obesity Obesity - blood Obesity - genetics older men Phenotype Physical Sciences Polymorphism, Single Nucleotide Preventive medicine Randomization Research and Analysis Methods risk-factors Science & Technology - Other Topics Ships Single-nucleotide polymorphism Smoking Social Sciences Studies Testosterone Testosterone - blood Weight reduction Young Adult |
| SummonAdditionalLinks | – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwELWgcOAClI82UJCREIJD2nXiJDYXVCoqThVCgHqL7NjeRuomYbPppX-eGcdZFFHBgVtkO4nteWOPx_YbQl47xSulmItzLZOYW4eOJsbiQklTFdqxhdM-2ERxdibOz-WX4HDrw7HKaUz0A7VpK_SRHzGJ4S2RTupD9zPGqFG4uxpCaNwmdxjaxoDn4uuPaSQGXc7zcF0uLdhRkM5h1zb2EJCYJ0Uxm448az-ynF62_U0W558HJ2f0on5KOn3wv415SO4HY5Qej-jZJbds84jsBnXv6dvASf3uMbk-UUMPRdfT2bmLuqPhjBdtx-ACVDWGAqKHFd1gvBqkYIA-oHhnaehp3dCVbd7TY6rreJxJvRsSU41FbwuFedO0q3AzFD438qU8Id9PP307-RyHuA1xxSXfxMYlQoM4RGZU7hY2yZXJF1orkIfg2lSOC6lc6lhmC6WUMwpZ9mG1zGwuYQh6SnYaqN8-oaLKK-akwu1mnlqpM8NT7eBBWGZlFpF0El9ZBVJzjK1xWfqdugIWN2NXlij0Mgg9IvH2rW4k9fhH-Y-IjG1ZpOT2Ce16WQYNL7kViYTagQkHS7TEKCk5h05ItAJtyNKI7COuph_05W8QRORggsnN2a-22aD8uKOjGtsOUEYgPT70G5TZG6G5rSTYHRxsMRmRYgbaWSvmOU194QnGkZRRLKDZb0Z4z15ZDl0JScuh7G2ZZBzsz2d_r_9zci9BY8g7rg7IzmY92BfkbnW1qfv1S6-yvwCBylJr priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELagcOAClFcDBRkJITikbBzHsbmVihUHVPUAUm-WHdttpG6y2my48OeZSZxFgVaI28oeb-zJN_GMH98Q8iYYXhmThVRYxVLuAy40ZVlaGuWq0oZsEeyQbKI8PZXn5-rsd6D4xw5-XmYfok6P1m3jjwA_gpXlbXKH5UJgsLU8-zp9ecF2hYjX425qOZt-BpZ-ZDW9arvrPMy_D0rO6ESHKWj54H87_5Dcj84mPR7RsU9u-eYR2Y_m3NF3kXP6_WPy88T0HYhuprNxl_WaxjNctB2TB1DTOAqI7Vd0i_lokGIBHkjxTlLf0bqhK998pMfU1uk4Uw7LjFjqPK6mUJgXXbuKNz_h70Y-lCfk-_Lzt5MvaczLkFZc8W3qApMWQhFZOCPCwjNhnFhYa0D_kltXBS6VCXnICl8aY4IzyKIP0XDmhYJPzFOy10D_DgiVlaiyoAxuJ_PcK1s4ntsAP6TPvCoSkk-vS1eRtBxzZ1zpYSeuhOBlVKVGDeuo4YSku1brkbTjH_KfEAk7WaTcHgrgVepowZp7yRT0Dlw0CMGYM0pxDkpg1gDaizwhB4ij6QGdzhQmZEUCtIQcTti6vvr1rhqMG3dsTOPbHmQk0t-D3kDm2QjFXSfBr-Dga6mElDOQzkYxr2nqy4FAHEkX5QKG_XaE86zJRb_WUHTR685rVnDwL5_fPLQX5B5DR2dYlDoke9tN71-Su9WPbd1tXg3m-QsoRUCq priority: 102 providerName: Public Library of Science |
| Title | Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28448539 https://www.proquest.com/docview/1990007905 https://www.proquest.com/docview/1893553315 https://pubmed.ncbi.nlm.nih.gov/PMC5407807 https://gup.ub.gu.se/publication/254175 https://doaj.org/article/4e829d436637472da99445582bacaa53 http://dx.doi.org/10.1371/journal.pone.0176277 |
| Volume | 12 |
| WOSCitedRecordID | wos000400383600055&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest advanced technologies & aerospace journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdg8MAL2vha2aiMhBA8pEtSJ7Z5W6tVoLEqGh8qvEROYm-V1rRqGl7457mz3YqISXvh5RTZ58Q-n3Pnr98R8sYoVioVmSAtZBwwbXChKYoCrmRV8sJEoSlssAk-nYrZTGZ_hfrCM2EOHtgJ7oRpEcuKDcEygucbV0pKxpJExIWCjyQW5zPkcjuZcv9gGMVp6i_KDXl04vtlsFrWegA6mMacdwyRxetHfNObZXObr_nvkckOsKg1RpN98th7kfTU1f6A3NP1E3Lgx2lD33kw6fdPye-xahtgXW8PvV3PV9QfzqJLFxWAqrqioIrtgm4w0AxiJ0ATKF42ahs6r-lC1x_oKS3mgTOBdv0QUyuNyyQUDF61XPgrnfA6B3TyjHybnH0dfwx8wIWgZJJtgsrEooA5hkgqlZpQx6mq0rAoFIhTsKIqDRNSmaGJEs2VUqZSCI8P09xIpxL-Hc_JXg31OyRUlGkZGalwn5gNtSwS6MPCwIPQkZZJjwy30s9Lj0aOQTFucrvFxmFW4kSZY5_lvs96JNiVWjk0jjv4R9ixO17E0rYJoGG517D8Lg3rkUNUi-0HmjySGGkVkc165HirKrdnv95lw6jFrRhV62ULPAJx7UFuwPPCadaukuAwMHCiZI_wjs51WtHNqefXFhkc0RRFCM1-67SzU-SqXeWQdNXmjc7jhIHj-PJ_yOeIPIrR17HrUsdkb7Nu9SvysPy1mTfrPrnPL78jnXFLBVAxjvrkwehsml327bgFOsk-Az0fDYBehOdIeWbpF6BZ8hNKZJ8ush9_AAIbT-s |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKQYILUF5dKGAkQHBIu3GcxEZCqBSqVi2rHopUcTF2bG9X6ibLZgNC_Cd-IzN5LIqo4NQDt5U9yTqTmcnnsf0NIU-95pnWoQ8SI1nAncdEUxgGqZY2S40Ph97UxSbS0UicnMijFfKzOwuD2yq7mFgHaltkmCPfCiWWt0Q6qTezLwFWjcLV1a6ERmMWB-77N5iyla_338H7fcbY7vvjnb2grSoQZFzyRWA9EwaAtIitTvzQsUTbZGiMjkQiuLGZ50JqH_kwdqnW2luNHPAwlwtdIsFB4L6XyGXO2RC96Cj-1EV-iB1J0h7Pi9Jwq7WGzVmRu02w_ISlae_zV1cJQFbVs6I8D-H-uVGzR2dafwJ3b_xvyrtJrrdgm2433rFGVlx-i6y14aykL1rO7Ze3yY8dXZUgOu_2Bp5OZrTdw0aLpngC1bml4LHVlC6wHg9STIDOKZ7Jqko6yenU5a_oNjWToEEKdZoVW63DbBIFXGCLaXvyFW7X8MHcIR8vRAl3yWoO41snVGRJFnqpcTmdR06a2PLIePghXOhkPCBRZy4qa0nbsXbImapXIlOYvDWqVGhkqjWyAQmWV80a0pJ_yL9FS1zKIuV43VDMx6qNYIo7wSSMDiAqTEGZ1VJyDkpgRoO3x9GArKMdd39Qqt9GNyAbnVme3_1k2Q3BDVesdO6KCmQE0v-D3kDmXuMKy0ECruKANeWApD0n6T1FvyefnNYE6kg6KYbw2M8bd-pdMq5mCprGlSqdYjEHfH3_7-N_TK7uHX84VIf7o4MH5BpD4Fcn6TbI6mJeuYfkSvZ1MSnnj-pwQcnni3axX7ZLsKg |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fb9MwELfGQIgXYPxbYYCRAMFD1iZxEhsJobFRMQ1VfQBp2kuwY7uLtCalaUCIb8an4y5xiiImeNoDb5F9SZzL3fl8Pv-OkKdWskxK33qxEoHHjMVAk-97iRQ6S5T1R1Y1xSaSyYQfH4vpBvnZnYXBtMrOJjaGWpcZxsiHvsDylggnNbQuLWJ6MH6z-OJhBSncae3KabQicmS-f4PlW_X68AD-9bMgGL_7uP_ecxUGvIwJtvK0DbgCp5pHWsZ2ZIJY6niklAx5zJnSmWVcSBtaPzKJlNJqiXjwsK7zTSxAWeC5l8jlBNaYmE44jU66WQDsSBy7o3ph4g-dZOwuysLsghbEQZL0psKmYgAirJ6V1Xne7p9Jmz1o02Y6HN_4nxl5k1x3Tjjda7Vmi2yY4hbZcmauoi8cFvfL2-THvqwrIF12OYOn-YK63DZatkUVqCw0BU2u53SFdXoQegL4T_GsVl3RvKBzU7yie1TlXutBNOFXbNUGo0wU_AVdzt2JWHhcixNzh3y6ECbcJZsFjG-bUJ7FmW-FxG12FhqhIs1CZeGCG9-IaEDCTnTSzIG5Y02Rs7TZoUxgUdeyMkWBS53ADYi3vmvRgpn8g_4tSuWaFqHIm4ZyOUudZUuZ4YGA0YHrCkvTQEshGAMmBEqCFYjCAdlGme5eUKW_BXBAdjoRPb_7ybobjB7uZMnClDXQcCwLAHwDmnutWqwHCf4WAx9UDEjSU5jeV_R7ivy0AVZHMEo-gs9-3qpW75ZZvUihaVanlUmDiIHfff_v439MroJmpR8OJ0cPyLUA_cEmdrdDNlfL2jwkV7Kvq7xaPmosByWfL1rDfgGj6rly |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Causal+relationship+between+obesity+and+serum+testosterone+status+in+men%3A+A+bi-directional+mendelian+randomization+analysis&rft.jtitle=PloS+one&rft.au=Joel+Eriksson&rft.au=Robin+Haring&rft.au=Niels+Grarup&rft.au=Liesbeth+Vandenput&rft.date=2017&rft.pub=Public+Library+of+Science+%28PLoS%29&rft.eissn=1932-6203&rft.volume=12&rft.issue=4&rft.spage=e0176277&rft_id=info:doi/10.1371%2Fjournal.pone.0176277&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_4e829d436637472da99445582bacaa53 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |