Integrin β5 interacts with G3BP1 through activating FAK/Src signaling pathway to promote gastric carcinogenesis

Previous studies demonstrated that integrin β5 (ITGB5) play an important role in the occurrence and development of various malignant tumors. However, its functional mechanism in gastric cancer (GC) remains obscure. We detected that ITGB5 was overexpressed in GC tissues and its high-level expression...

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Veröffentlicht in:	Scientific reports Jg. 15; H. 1; S. 28633 - 13
Hauptverfasser:	Liu, Dongliang, Cao, Jianjian, Hu, Kongwang, Peng, Zhiwei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 05.08.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	692/4028 692/499 692/53 692/699/1503/1504 692/700 Binding sites Cancer therapies Carcinogenesis Cell growth Cell proliferation Chemical bonds Efficiency FAK/Src signaling Focal adhesion kinase G3BP1 Gastric cancer Gastric carcinogenesis Humanities and Social Sciences Integrin β5 Invasion Invasiveness Kinases Ligands Medical prognosis Metastasis multidisciplinary Pancreatic cancer Phosphorylation Protein expression Proteins Science Science (multidisciplinary) Signal transduction Therapeutic targets Tumorigenesis Wound healing Gastric carcinogenesis FAK/Src signaling Integrin β5 Invasion G3BP1
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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