Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants

Smelling is a human sense, expressing strong sexual dimorphisms. We aim to improve the knowledge of the genetics of human olfactory perception by performing an exploratory genome-wide association meta-analysis of up to 21,495 individuals of European ancestry. By sex-stratified and overall analysis o...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 5434 - 15
Main Authors:	Förster, Franz, Emmert, David, Horn, Katrin, Pott, Janne, Frasnelli, Johannes, Imtiaz, Mohammed Aslam, Melas, Konstantinos, Talevi, Valentina, Chen, Honglei, Engel, Christoph, Filosi, Michele, Fornage, Myriam, Gögele, Martin, Löffler, Markus, Mosley, Thomas H., Pattaro, Cristian, Pramstaller, Peter, Shrestha, Srishti, Aziz, N. Ahmad, Breteler, Monique M. B., Wirkner, Kerstin, Scholz, Markus, Fuchsberger, Christian
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.07.2025 Nature Publishing Group Nature Portfolio
Subjects:	45/43 631/208/205/2138 692/4017 Alzheimer Disease - genetics Alzheimer's disease Amygdala Chemosensory perception Clusters Disease Female Females Genes Genetic diversity Genetic variance Genetic Variation Genetics Genome-Wide Association Study Genomes Genomic analysis Health risks Hormones Humanities and Social Sciences Humans Identification Male Males Mendelian Randomization Analysis Meta-analysis multidisciplinary Neurodegenerative diseases Odorant receptors Odorants - analysis Odors Olfactory discrimination Olfactory perception Olfactory Perception - genetics Parkinson's disease Perception Polymorphism, Single Nucleotide Receptor density Receptors Receptors, Odorant - genetics Regulatory sequences Science Science (multidisciplinary) Sex Characteristics Sex hormones Sexual dimorphism Smell - genetics White People - genetics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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