Natural Plasmodium falciparum Infection Stimulates Human Antibodies to MSP1 Epitopes Identified in Mice Infection Models upon Non-Natural Modified Peptidomimetic Vaccination
(1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the Plasmodium genus, responsible for increased extreme morbidity and mortality rates. Despite advances in approved vaccines, full protection has not yet been achieved upon vaccination, thus the development of more...
Saved in:
| Published in: | Molecules (Basel, Switzerland) Vol. 28; no. 6; p. 2527 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
MDPI AG
10.03.2023
MDPI |
| Subjects: | |
| ISSN: | 1420-3049, 1420-3049 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | (1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the Plasmodium genus, responsible for increased extreme morbidity and mortality rates. Despite advances in approved vaccines, full protection has not yet been achieved upon vaccination, thus the development of more potent and safe immuno-stimulating agents for malaria prevention is a goal to be urgently accomplished. We have focused our research on a strategy to identify Plasmodium spp. epitopes by naturally acquired human antibodies and rodent malaria infection models immunized with site-directed non-natural antigens. (2) Methods: Some predictive algorithms and bioinformatics tools resembling different biological environments, such as phagosome-lysosome proteolytic degradation, affinity, and the high frequency of malaria-resistant and -sensitive HLA-II alleles were regarded for the proper selection of epitopes and potential testing. Each epitope’s binding profile to both host cells and HLA-II molecules was considered for such initial screening. (3) Results: Once selected, we define each epitope-peptide to be synthesized in terms of size and hydrophobicity, and introduced peptide-bond surrogates and non-natural amino acids in a site-directed fashion, and then they were produced by solid-phase peptide synthesis. Molecules were then tested by their antigenic and immunogenic properties compared to human sera from Colombian malaria-endemic areas. The antigenicity and protective capacity of each epitope-peptide in a rodent infection model were examined. The ability of vaccinated mice after being challenged with P. berghei ANKA and P. yoelii 17XL to control malaria led to the determination of an immune stimulation involving Th1 and Th1/Th2 mechanisms. In silico molecular dynamics and modeling provided some interactions insights, leading to possible explanations for protection due to immunization. (4) Conclusions: We have found evidence for proposing MSP1-modified epitopes to be considered as neutralizing antibody stimulators that are useful as probes for the detection of Plasmodium parasites, as well as for sub-unit components of a site-directed designed malaria vaccine candidate. |
|---|---|
| AbstractList | (1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the Plasmodium genus, responsible for increased extreme morbidity and mortality rates. Despite advances in approved vaccines, full protection has not yet been achieved upon vaccination, thus the development of more potent and safe immuno-stimulating agents for malaria prevention is a goal to be urgently accomplished. We have focused our research on a strategy to identify Plasmodium spp. epitopes by naturally acquired human antibodies and rodent malaria infection models immunized with site-directed non-natural antigens. (2) Methods: Some predictive algorithms and bioinformatics tools resembling different biological environments, such as phagosome-lysosome proteolytic degradation, affinity, and the high frequency of malaria-resistant and -sensitive HLA-II alleles were regarded for the proper selection of epitopes and potential testing. Each epitope’s binding profile to both host cells and HLA-II molecules was considered for such initial screening. (3) Results: Once selected, we define each epitope-peptide to be synthesized in terms of size and hydrophobicity, and introduced peptide-bond surrogates and non-natural amino acids in a site-directed fashion, and then they were produced by solid-phase peptide synthesis. Molecules were then tested by their antigenic and immunogenic properties compared to human sera from Colombian malaria-endemic areas. The antigenicity and protective capacity of each epitope-peptide in a rodent infection model were examined. The ability of vaccinated mice after being challenged with P. berghei ANKA and P. yoelii 17XL to control malaria led to the determination of an immune stimulation involving Th1 and Th1/Th2 mechanisms. In silico molecular dynamics and modeling provided some interactions insights, leading to possible explanations for protection due to immunization. (4) Conclusions: We have found evidence for proposing MSP1-modified epitopes to be considered as neutralizing antibody stimulators that are useful as probes for the detection of Plasmodium parasites, as well as for sub-unit components of a site-directed designed malaria vaccine candidate. (1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the Plasmodium genus, responsible for increased extreme morbidity and mortality rates. Despite advances in approved vaccines, full protection has not yet been achieved upon vaccination, thus the development of more potent and safe immuno-stimulating agents for malaria prevention is a goal to be urgently accomplished. We have focused our research on a strategy to identify Plasmodium spp. epitopes by naturally acquired human antibodies and rodent malaria infection models immunized with site-directed non-natural antigens. (2) Methods: Some predictive algorithms and bioinformatics tools resembling different biological environments, such as phagosome-lysosome proteolytic degradation, affinity, and the high frequency of malaria-resistant and -sensitive HLA-II alleles were regarded for the proper selection of epitopes and potential testing. Each epitope's binding profile to both host cells and HLA-II molecules was considered for such initial screening. (3) Results: Once selected, we define each epitope-peptide to be synthesized in terms of size and hydrophobicity, and introduced peptide-bond surrogates and non-natural amino acids in a site-directed fashion, and then they were produced by solid-phase peptide synthesis. Molecules were then tested by their antigenic and immunogenic properties compared to human sera from Colombian malaria-endemic areas. The antigenicity and protective capacity of each epitope-peptide in a rodent infection model were examined. The ability of vaccinated mice after being challenged with P. berghei ANKA and P. yoelii 17XL to control malaria led to the determination of an immune stimulation involving Th1 and Th1/Th2 mechanisms. In silico molecular dynamics and modeling provided some interactions insights, leading to possible explanations for protection due to immunization. (4) Conclusions: We have found evidence for proposing MSP1-modified epitopes to be considered as neutralizing antibody stimulators that are useful as probes for the detection of Plasmodium parasites, as well as for sub-unit components of a site-directed designed malaria vaccine candidate.(1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the Plasmodium genus, responsible for increased extreme morbidity and mortality rates. Despite advances in approved vaccines, full protection has not yet been achieved upon vaccination, thus the development of more potent and safe immuno-stimulating agents for malaria prevention is a goal to be urgently accomplished. We have focused our research on a strategy to identify Plasmodium spp. epitopes by naturally acquired human antibodies and rodent malaria infection models immunized with site-directed non-natural antigens. (2) Methods: Some predictive algorithms and bioinformatics tools resembling different biological environments, such as phagosome-lysosome proteolytic degradation, affinity, and the high frequency of malaria-resistant and -sensitive HLA-II alleles were regarded for the proper selection of epitopes and potential testing. Each epitope's binding profile to both host cells and HLA-II molecules was considered for such initial screening. (3) Results: Once selected, we define each epitope-peptide to be synthesized in terms of size and hydrophobicity, and introduced peptide-bond surrogates and non-natural amino acids in a site-directed fashion, and then they were produced by solid-phase peptide synthesis. Molecules were then tested by their antigenic and immunogenic properties compared to human sera from Colombian malaria-endemic areas. The antigenicity and protective capacity of each epitope-peptide in a rodent infection model were examined. The ability of vaccinated mice after being challenged with P. berghei ANKA and P. yoelii 17XL to control malaria led to the determination of an immune stimulation involving Th1 and Th1/Th2 mechanisms. In silico molecular dynamics and modeling provided some interactions insights, leading to possible explanations for protection due to immunization. (4) Conclusions: We have found evidence for proposing MSP1-modified epitopes to be considered as neutralizing antibody stimulators that are useful as probes for the detection of Plasmodium parasites, as well as for sub-unit components of a site-directed designed malaria vaccine candidate. (1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the genus, responsible for increased extreme morbidity and mortality rates. Despite advances in approved vaccines, full protection has not yet been achieved upon vaccination, thus the development of more potent and safe immuno-stimulating agents for malaria prevention is a goal to be urgently accomplished. We have focused our research on a strategy to identify spp. epitopes by naturally acquired human antibodies and rodent malaria infection models immunized with site-directed non-natural antigens. (2) Methods: Some predictive algorithms and bioinformatics tools resembling different biological environments, such as phagosome-lysosome proteolytic degradation, affinity, and the high frequency of malaria-resistant and -sensitive HLA-II alleles were regarded for the proper selection of epitopes and potential testing. Each epitope's binding profile to both host cells and HLA-II molecules was considered for such initial screening. (3) Results: Once selected, we define each epitope-peptide to be synthesized in terms of size and hydrophobicity, and introduced peptide-bond surrogates and non-natural amino acids in a site-directed fashion, and then they were produced by solid-phase peptide synthesis. Molecules were then tested by their antigenic and immunogenic properties compared to human sera from Colombian malaria-endemic areas. The antigenicity and protective capacity of each epitope-peptide in a rodent infection model were examined. The ability of vaccinated mice after being challenged with ANKA and 17XL to control malaria led to the determination of an immune stimulation involving Th1 and Th1/Th2 mechanisms. In silico molecular dynamics and modeling provided some interactions insights, leading to possible explanations for protection due to immunization. (4) Conclusions: We have found evidence for proposing MSP1-modified epitopes to be considered as neutralizing antibody stimulators that are useful as probes for the detection of parasites, as well as for sub-unit components of a site-directed designed malaria vaccine candidate. |
| Author | Torres, Angela Lozano, José Manuel Melo, Fredy Leonardo Rodríguez, Zully Johana Agrawal, Nikhil Cortés-Vecino, Jesús Alfredo |
| AuthorAffiliation | 1 Departamento de Farmacia, Mimetismo Molecular de los Agentes Infecciosos, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30#45-03, Bogotá DC 111321, Colombia 4 Laboratorio de Parasitología Veterinaria, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30#45-03, Bogotá DC 111321, Colombia 3 College of Health Sciences, Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Westville, Durban 4000, South Africa 2 Departamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30#45-03, Bogotá DC 111321, Colombia |
| AuthorAffiliation_xml | – name: 4 Laboratorio de Parasitología Veterinaria, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30#45-03, Bogotá DC 111321, Colombia – name: 2 Departamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30#45-03, Bogotá DC 111321, Colombia – name: 1 Departamento de Farmacia, Mimetismo Molecular de los Agentes Infecciosos, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30#45-03, Bogotá DC 111321, Colombia – name: 3 College of Health Sciences, Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Westville, Durban 4000, South Africa |
| Author_xml | – sequence: 1 givenname: Zully Johana surname: Rodríguez fullname: Rodríguez, Zully Johana – sequence: 2 givenname: Fredy Leonardo surname: Melo fullname: Melo, Fredy Leonardo – sequence: 3 givenname: Angela surname: Torres fullname: Torres, Angela – sequence: 4 givenname: Nikhil surname: Agrawal fullname: Agrawal, Nikhil – sequence: 5 givenname: Jesús Alfredo orcidid: 0000-0003-2641-604X surname: Cortés-Vecino fullname: Cortés-Vecino, Jesús Alfredo – sequence: 6 givenname: José Manuel orcidid: 0000-0001-6039-0213 surname: Lozano fullname: Lozano, José Manuel |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36985500$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks9u1DAQxiNURP_AA3BBlrj0suA4juOcUFUVulK3rFTgak3scXGV2CF2kHgo3hFvt4u2RZw8mvm-nz7bc1wc-OCxKF6X9F1VtfT9EHrUc4-RSSpYzZpnxVHJGV1UlLcHe_VhcRzjHaWs5GX9ojisRCvrmtKj4vc1pHmCnqx7iEMwbh6IhV67EaZcLr1FnVzw5Ca5Ye4hYSSX8wCenPnkumzIjRTI6mZdkovRpTDmxtJgnlqHhjhPVk7jHmkVDPaRzGOur4Nf7BLk_tayxjE5EwY3YHKafAOtnYeN92XxPIeL-OrhPCm-frz4cn65uPr8aXl-drXQvOVpobVh1kKDwGktdVWj5Fx0CJJRyYURKBtgJSLqTuiuk7qFmlattrXojLHVSbHcck2AOzVOboDplwrg1H0jTLcKppytRyU7w8BC9oqSc0PBClpRjdxSwRlWmfVhyxrnbkCj88vk2z6CPp54913dhp-qpLRuZCUz4fSBMIUfM8akBhc19j14DHNUrGlZTVtJmyx9-0R6F-bJ57faqEoh8wpsgG_2I_3NsluLLGi2Aj2FGCe0Srt0_wM5oetzNLVZQPXPAmZn-cS5g__f8wddU-ZK |
| CitedBy_id | crossref_primary_10_1007_s00436_024_08276_0 |
| Cites_doi | 10.1111/j.1399-0039.2011.01661.x 10.1016/S0166-6851(98)00045-0 10.1038/nm.3083 10.1016/j.vaccine.2021.09.024 10.1038/nature01094 10.1084/jem.20011194 10.1016/0166-6851(95)02518-9 10.1016/S1471-4906(02)00012-1 10.1016/j.molimm.2004.04.019 10.1016/j.tibs.2009.04.001 10.1111/imm.12889 10.1002/1521-4141(200212)32:12<3667::AID-IMMU3667>3.0.CO;2-C 10.1046/j.1365-3024.1996.d01-15.x 10.1038/s41541-017-0035-3 10.1016/0952-7915(94)90128-7 10.1371/journal.pone.0002830 10.1016/j.bbrc.2004.01.072 10.1016/0022-2836(87)90649-8 10.1093/nar/gkx346 10.1016/j.peptides.2007.07.029 10.1016/j.tips.2022.10.005 10.1186/1471-2164-6-79 10.1016/j.vaccine.2010.01.019 10.2174/138527206776055358 10.1038/mt.2012.223 10.1093/nar/gku938 10.1093/bioinformatics/btp033 10.1016/j.bbrc.2012.10.089 10.1128/IAI.68.3.1252-1258.2000 10.1016/S0300-9084(03)00002-6 10.3389/fimmu.2017.00278 10.1155/2021/7785180 10.3389/fcimb.2021.631019 10.1038/368215a0 10.1016/j.jsb.2004.04.010 10.1002/jmr.893 10.1586/erv.12.57 10.1016/j.bbrc.2014.06.143 10.1007/s00726-013-1541-x 10.1186/1475-2875-13-349 10.1111/j.1399-3011.1998.tb01250.x 10.1016/j.coi.2015.06.008 10.1007/s00726-006-0485-9 10.3390/molecules22111837 |
| ContentType | Journal Article |
| Copyright | 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 by the authors. 2023 |
| Copyright_xml | – notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2023 by the authors. 2023 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.3390/molecules28062527 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database (subscription) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1420-3049 |
| ExternalDocumentID | oai_doaj_org_article_8bd2afa9cf6144d0af6030ce4f0642e3 PMC10057838 36985500 10_3390_molecules28062527 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Universidad Nacional de Colombia, Vicerrectoría de Investigación HERMES grantid: 42129; 48164; 35925 – fundername: Colombian Ministry of Sciences MinCiencias formerly Colciencias |
| GroupedDBID | --- 0R~ 123 2WC 53G 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACGFO ACIWK ACPRK ACUHS AEGXH AENEX AFFHD AFKRA AFPKN AFRAH AFZYC AIAGR ALMA_UNASSIGNED_HOLDINGS BENPR BPHCQ BVXVI CCPQU CITATION CS3 D1I DIK DU5 E3Z EBD EMOBN ESTFP ESX FYUFA GROUPED_DOAJ GX1 HH5 HMCUK HYE HZ~ I09 IAO IHR ITC KQ8 LK8 M1P MODMG O-U O9- OK1 P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO RPM SV3 TR2 TUS UKHRP ~8M 3V. ABJCF ALIPV BBNVY BHPHI CGR CUY CVF ECM EIF HCIFZ KB. M7P M~E NPM PDBOC 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c494t-ccd2ffa7ea4058c35e8446bea820846d6e87a21eeecb6cbb8c9a5039cf56bddf3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 1 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000959222400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1420-3049 |
| IngestDate | Tue Oct 14 19:07:52 EDT 2025 Tue Nov 04 02:07:22 EST 2025 Thu Oct 02 06:16:48 EDT 2025 Tue Oct 07 07:16:48 EDT 2025 Wed Feb 19 02:24:26 EST 2025 Sat Nov 29 07:11:12 EST 2025 Tue Nov 18 22:17:44 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | site-directed modification malaria vaccine synthetic epitopes peptide-bond isostere |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c494t-ccd2ffa7ea4058c35e8446bea820846d6e87a21eeecb6cbb8c9a5039cf56bddf3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0001-6039-0213 0000-0003-2641-604X |
| OpenAccessLink | https://doaj.org/article/8bd2afa9cf6144d0af6030ce4f0642e3 |
| PMID | 36985500 |
| PQID | 2791680218 |
| PQPubID | 2032355 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8bd2afa9cf6144d0af6030ce4f0642e3 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10057838 proquest_miscellaneous_2792509807 proquest_journals_2791680218 pubmed_primary_36985500 crossref_citationtrail_10_3390_molecules28062527 crossref_primary_10_3390_molecules28062527 |
| PublicationCentury | 2000 |
| PublicationDate | 20230310 |
| PublicationDateYYYYMMDD | 2023-03-10 |
| PublicationDate_xml | – month: 3 year: 2023 text: 20230310 day: 10 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Molecules (Basel, Switzerland) |
| PublicationTitleAlternate | Molecules |
| PublicationYear | 2023 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Sheehy (ref_12) 2012; 20 Langhorne (ref_28) 2015; 5 Chen (ref_43) 2007; 33 ref_14 ref_11 Coelho (ref_3) 2017; 2 Garraud (ref_27) 2003; 24 Waterhouse (ref_38) 2009; 25 ref_51 Lozano (ref_48) 2007; 28 Cubillos (ref_17) 2002; 84 Garamszegi (ref_33) 2014; 13 Lozano (ref_53) 2023; 44 Tanabe (ref_10) 1987; 195 Vita (ref_41) 2015; 43 Sanni (ref_16) 2002; 72 Gerold (ref_8) 1996; 75 Vanegas (ref_23) 2014; 451 Murphy (ref_31) 1994; 6 ref_25 Riley (ref_30) 2013; 19 Lyke (ref_32) 2011; 77 Jespersen (ref_45) 2017; 45 Aucan (ref_26) 2000; 68 Stern (ref_34) 1994; 368 Daubenberger (ref_18) 2002; 32 Verspurten (ref_39) 2009; 34 Lozano (ref_15) 1998; 52 Hennecke (ref_35) 2002; 195 Popa (ref_29) 2021; 2021 Marshall (ref_9) 1998; 94 Sanz (ref_5) 2019; 10 Lozano (ref_20) 2004; 148 Fleri (ref_42) 2017; 8 Urquiza (ref_19) 1996; 18 Jensen (ref_46) 2018; 154 Espejo (ref_36) 2004; 315 Florez (ref_52) 2021; 11 Moreno (ref_2) 2015; 35 Singh (ref_50) 2010; 28 Bastian (ref_13) 2004; 41 Dobbs (ref_44) 2008; 21 Gardner (ref_37) 2002; 419 ref_47 Moon (ref_6) 2021; 39 ref_1 Patarroyo (ref_7) 2012; 11 Lozano (ref_21) 2006; 10 Patarroyo (ref_22) 2012; 429 ref_49 Saha (ref_40) 2005; 6 ref_4 Lozano (ref_24) 2013; 45 |
| References_xml | – volume: 77 start-page: 562 year: 2011 ident: ref_32 article-title: Association of HLA alleles with Plasmodium falciparum severity in Malian children publication-title: Tissue Antigens doi: 10.1111/j.1399-0039.2011.01661.x – ident: ref_49 – volume: 94 start-page: 13 year: 1998 ident: ref_9 article-title: Close Linkage of Three Merozoite Surface Protein Genes on Chromosome 2 of Plasmodium Falciparum publication-title: Mol. Biochem. Parasitol. doi: 10.1016/S0166-6851(98)00045-0 – volume: 19 start-page: 168 year: 2013 ident: ref_30 article-title: Immune Mechanisms in Malaria: New Insights in Vaccine Development publication-title: Nat. Med. doi: 10.1038/nm.3083 – volume: 39 start-page: 6398 year: 2021 ident: ref_6 article-title: A Phase IIA Extension Study Evaluating the Effect of Booster Vaccination with a Fractional Dose of RTS,S/AS01E in a Controlled Human Malaria Infection Challenge publication-title: Vaccine doi: 10.1016/j.vaccine.2021.09.024 – volume: 419 start-page: 527 year: 2002 ident: ref_37 article-title: Sequence of Plasmodium falciparum Chromosomes 2, 10, 11 and 14 publication-title: Nature doi: 10.1038/nature01094 – ident: ref_51 – volume: 195 start-page: 571 year: 2002 ident: ref_35 article-title: Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): Insight into TCR cross-restriction and alloreactivity publication-title: J. Exp. Med. doi: 10.1084/jem.20011194 – volume: 75 start-page: 131 year: 1996 ident: ref_8 article-title: Structural Analysis of the Glycosyl-Phosphatidylinositol Membrane Anchor of the Merozoite Surface Proteins-1 and -2 of Plasmodium Falciparum publication-title: Mol. Biochem. Parasitol. doi: 10.1016/0166-6851(95)02518-9 – volume: 24 start-page: 30 year: 2003 ident: ref_27 article-title: Malaria-Specific Antibody Subclasses in Immune Individuals: A Key Source of Information for Vaccine Design publication-title: Trends Immunol. doi: 10.1016/S1471-4906(02)00012-1 – volume: 41 start-page: 775 year: 2004 ident: ref_13 article-title: Characterization of a Reduced Peptide Bond Analogue of a Promiscuous CD4 T Cell Epitope Derived from the Plasmodium falciparum Malaria Vaccine Candidate Merozoite Surface Protein 1 publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2004.04.019 – ident: ref_1 – volume: 5 start-page: 1 year: 2015 ident: ref_28 article-title: CD4 T-Cell Subsets in Malaria: TH1/TH2 Revisited publication-title: Front. Immunol. – volume: 34 start-page: 319 year: 2009 ident: ref_39 article-title: SitePredicting the Cleavage of Proteinase Substrates publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2009.04.001 – volume: 154 start-page: 394 year: 2018 ident: ref_46 article-title: Improved Methods for Predicting Peptide Binding Affinity to MHC Class II Molecules publication-title: Immunology doi: 10.1111/imm.12889 – volume: 32 start-page: 3667 year: 2002 ident: ref_18 article-title: Amino Acid Dimorphism and Parasite Immune Evasion: Cellular Immune Responses to a Promiscuous Epitope of Plasmodium falciparum Merozoite Surface Protein 1 Displaying Dimorphic Amino Acid Polymorphism Are Highly Constrained publication-title: Eur. J. Immunol. doi: 10.1002/1521-4141(200212)32:12<3667::AID-IMMU3667>3.0.CO;2-C – volume: 18 start-page: 515 year: 1996 ident: ref_19 article-title: Identification of Plasmodium falciparum MSP-1 Peptides Able to Bind to Human Red Blood Cells publication-title: Parasite Immunol. doi: 10.1046/j.1365-3024.1996.d01-15.x – ident: ref_4 – volume: 10 start-page: 1 year: 2019 ident: ref_5 article-title: Concentration and Avidity of Antibodies to Different Circumsporozoite Epitopes Correlate with RTS,S/AS01E Malaria Vaccine Efficacy publication-title: Nat. Commun. – volume: 2 start-page: 34 year: 2017 ident: ref_3 article-title: Advances in Malaria Vaccine Development: Report from the 2017 Malaria Vaccine Symposium publication-title: NPJ Vaccines doi: 10.1038/s41541-017-0035-3 – volume: 6 start-page: 458 year: 1994 ident: ref_31 article-title: Role of Cytokines in Determining T-Lymphocyte Function publication-title: Curr. Opin. Immunol. doi: 10.1016/0952-7915(94)90128-7 – ident: ref_11 doi: 10.1371/journal.pone.0002830 – volume: 315 start-page: 418 year: 2004 ident: ref_36 article-title: Shortening and modifying the 1513 MSP-1 peptide’s alpha-helical region induces protection against malaria publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2004.01.072 – volume: 195 start-page: 273 year: 1987 ident: ref_10 article-title: Allelic Dimorphism in a Surface Antigen Gene of the Malaria Parasite Plasmodium Falciparum publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(87)90649-8 – volume: 45 start-page: W24 year: 2017 ident: ref_45 article-title: BepiPred-2.0: Improving Sequence-Based B-Cell Epitope Prediction Using Conformational Epitopes publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx346 – volume: 28 start-page: 1954 year: 2007 ident: ref_48 article-title: Antibodies Induced by Plasmodium falciparum Merozoite Surface Antigen-2-Designed Pseudopeptides Possess Neutralizing Properties of the in vitro Malarial Infection publication-title: Peptides doi: 10.1016/j.peptides.2007.07.029 – volume: 44 start-page: 15 year: 2023 ident: ref_53 article-title: Monkeypox: Potential vaccine development strategies publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2022.10.005 – volume: 6 start-page: 1 year: 2005 ident: ref_40 article-title: Bcipep: A Database of B-Cell Epitopes publication-title: BMC Genom. doi: 10.1186/1471-2164-6-79 – volume: 28 start-page: 2580 year: 2010 ident: ref_50 article-title: Genetic Linkage of Autologous T Cell Epitopes in a Chimeric Recombinant Construct Improves Anti-Parasite and Anti-Disease Protective Effect of a Malaria Vaccine Candidate publication-title: Vaccine doi: 10.1016/j.vaccine.2010.01.019 – volume: 10 start-page: 433 year: 2006 ident: ref_21 article-title: What Is Hidden Behind Peptide Bond Restriction and Alfa-Carbon Asymmetry of Conserved Antigens? Peptide Bond Isosters and Chirally Transformed Pseudopeptides as Novel Elements for Synthetic Vaccines and Therapeutic Agents Against Malaria publication-title: Curr. Org. Chem. doi: 10.2174/138527206776055358 – volume: 20 start-page: 2355 year: 2012 ident: ref_12 article-title: ChAd63-MVA-Vectored Blood-Stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy against Mosquito Bite Challenge in Humans publication-title: Mol. Ther. doi: 10.1038/mt.2012.223 – volume: 43 start-page: D405 year: 2015 ident: ref_41 article-title: The Immune Epitope Database (IEDB) 3.0 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku938 – volume: 25 start-page: 1189 year: 2009 ident: ref_38 article-title: Jalview Version 2-A Multiple Sequence Alignment Editor and Analysis Workbench publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp033 – ident: ref_14 – volume: 429 start-page: 75 year: 2012 ident: ref_22 article-title: Phi (Φ) and Psi (Ψ) Angles Involved in Malarial Peptide Bonds Determine Sterile Protective Immunity publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2012.10.089 – volume: 68 start-page: 1252 year: 2000 ident: ref_26 article-title: High Immunoglobulin G2 (IgG2) and Low IgG4 Levels Are Associated with Human Resistance to Plasmodium falciparum Malaria publication-title: Infect. Immun. doi: 10.1128/IAI.68.3.1252-1258.2000 – volume: 84 start-page: 1181 year: 2002 ident: ref_17 article-title: Protection against Experimental P. falciparum Malaria Is Associated with Short AMA-1 Peptide Analogue α-Helical Structures publication-title: Biochimie doi: 10.1016/S0300-9084(03)00002-6 – volume: 8 start-page: 278 year: 2017 ident: ref_42 article-title: The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.00278 – volume: 2021 start-page: 7785180 year: 2021 ident: ref_29 article-title: Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines publication-title: J. Immunol. Res. doi: 10.1155/2021/7785180 – volume: 11 start-page: 631019 year: 2021 ident: ref_52 article-title: Leishmania Spp Epitopes in Humans Naturally Resistant to the Disease: Working Toward a Synthetic Vaccine publication-title: Front. Cell Infect. Microbiol. doi: 10.3389/fcimb.2021.631019 – ident: ref_25 – volume: 368 start-page: 215 year: 1994 ident: ref_34 article-title: Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide publication-title: Nature doi: 10.1038/368215a0 – volume: 148 start-page: 110 year: 2004 ident: ref_20 article-title: Mapping the Anatomy of a Plasmodium falciparum MSP-1 Epitope Using Pseudopeptide-Induced Mono- and Polyclonal Antibodies and CD and NMR Conformation Analysis publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2004.04.010 – volume: 21 start-page: 243 year: 2008 ident: ref_44 article-title: Predicting Linear B-Cell Epitopes Using String Kernels publication-title: J. Mol. Recognit. doi: 10.1002/jmr.893 – volume: 11 start-page: 1057 year: 2012 ident: ref_7 article-title: Towards the Development of a Fully Protective Plasmodium falciparum Antimalarial Vaccine publication-title: Expert. Rev. Vaccines doi: 10.1586/erv.12.57 – volume: 451 start-page: 15 year: 2014 ident: ref_23 article-title: Protecting Capacity against Malaria of Chemically Defined Tetramer Forms Based on the Plasmodium falciparum Apical Sushi Protein as Potential Vaccine Components publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2014.06.143 – volume: 45 start-page: 913 year: 2013 ident: ref_24 article-title: Redefining an Epitope of a Malaria Vaccine Candidate, with Antibodies against the N-Terminal MSA-2 Antigen of Plasmodium Harboring Non-Natural Peptide Bonds publication-title: Amino Acids doi: 10.1007/s00726-013-1541-x – volume: 13 start-page: 349 year: 2014 ident: ref_33 article-title: Global distribution of malaria-resistant MHC-HLA alleles: The number and frequencies of alleles and malaria risk publication-title: Malar. J. doi: 10.1186/1475-2875-13-349 – volume: 72 start-page: 57 year: 2002 ident: ref_16 article-title: Mouse Models for Erythrocytic-Stage Malaria publication-title: Methods Mol. Med. – volume: 52 start-page: 457 year: 1998 ident: ref_15 article-title: Reduced Amide Pseudopeptide Analogues of a Malaria Peptide Possess Secondary Structural Elements Responsible for Induction of Functional Antibodies Which React with Native Proteins Expressed in Plasmodium falciparum Erythrocyte Stages publication-title: J. Pept. Res. doi: 10.1111/j.1399-3011.1998.tb01250.x – volume: 35 start-page: 98 year: 2015 ident: ref_2 article-title: Malaria Vaccine Clinical Trials: What’s on the Horizon publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2015.06.008 – volume: 33 start-page: 423 year: 2007 ident: ref_43 article-title: Prediction of Linear B-Cell Epitopes Using Amino Acid Pair Antigenicity Scale publication-title: Amino Acids doi: 10.1007/s00726-006-0485-9 – ident: ref_47 doi: 10.3390/molecules22111837 |
| SSID | ssj0021415 |
| Score | 2.381833 |
| Snippet | (1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the Plasmodium genus, responsible for increased extreme morbidity and... (1) Background: Malaria, a vector-borne infectious disease, is caused by parasites of the genus, responsible for increased extreme morbidity and mortality... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 2527 |
| SubjectTerms | Amino acids Animals Antibodies Antigens Antigens, Protozoan Blood Epitopes Humans Immunoglobulins Immunology Infections Malaria Malaria - prevention & control malaria vaccine Malaria, Falciparum - prevention & control Merozoite Surface Protein 1 Mice Molecular structure Parasites peptide-bond isostere Peptides Peptidomimetics Plasmodium falciparum Proteins Protozoan Proteins - chemistry site-directed modification synthetic epitopes Vaccination Vaccines |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection (Proquest) dbid: 7X7 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Li9RAEG50FfTi-xFdpQVPQti80znJuuyi4A4DqzK30I_qNTB5OMn4r_yPVnUyszMqe_EWOp2hYL5UfdVVqY-xt4ksMCgoOl4ymZ9AJHwpU-WbIilAYsDKpRuZ_zmfzcRiUcynA7d-aqvc-ETnqE2r6Yz8KMqRyAiKSO-7Hz6pRlF1dZLQuMlukWw24TxfXCVcIUansZIZY2p_VI-Cs9BTNTFKSUhmJxa5kf3_4pl_tkvuxJ-z-_9r-QN2b2Ke_HiEykN2A5pH7M7JRvDtMfs1k24IB58jo65bU61rbuWSmq5XePlpattq-MVQ1aT6BT13NQB-3AyVaqkfkQ8tP7-Yh_y0Q1fR4cL4JbBFpsurhp-jX9r5JVJiW_Z83eH1rG38jQW4Pj4yp6Yb09ZVTR9b8m9S62o8v3zCvp6dfjn56E9qDr5OimTwtTaRtTIHiRxR6DgFgamoAokcBEmQyUDkMgoBQKtMKyV0IdMgLrRNM2WMjZ-yg6Zt4DnjIdUyNRK3QKvEpIlSALExKWVbuGg9Fmz-11JPo85JcWNZYspDUCj_goLH3m0f6cY5H9dt_kBg2W6kEd1uoV1dltMbXwplImkl2k85twmkzdChakgs5XwQe-xwA5dy8ht9eYUVj73Z3kYcUBlHNtCu3R7krYUI0I5nIzK3lsRZQRPqAo-JPczumbp_p6m-u6niIX2XLGLx4nq7XrK7EfI837U0HrKDYbWGV-y2_jlU_eq1e_9-A6DwQkI priority: 102 providerName: ProQuest |
| Title | Natural Plasmodium falciparum Infection Stimulates Human Antibodies to MSP1 Epitopes Identified in Mice Infection Models upon Non-Natural Modified Peptidomimetic Vaccination |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36985500 https://www.proquest.com/docview/2791680218 https://www.proquest.com/docview/2792509807 https://pubmed.ncbi.nlm.nih.gov/PMC10057838 https://doaj.org/article/8bd2afa9cf6144d0af6030ce4f0642e3 |
| Volume | 28 |
| WOSCitedRecordID | wos000959222400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: Directory of Open Access Journals customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: DOA dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: PIMPY dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9NAEF_0FPRF_DZ6lhV8EsKl-dx9vDt6eGBD8FTqU9hPDDRJaVL_K_9HZzZJaVX0xZeQbDZlmpnN_GZ39jeEvI0FB6cgcXpJp35sQuYLkUhf85gbAQ4rE44y_0OW52y14sVBqS_MCRvogYcXd8akDoUVXFkMXXQgbAp2qUxsETobx_MZZHwKpsZQaw5-aVjDjCCoP6uHUrOmw3XEMMESMgdeyJH1_wlh_pooeeB5rh6SByNkpOeDqI_ILdM8Jvcup0ptT8iPXDj2DFoAFK5bXe1qasUas6W3cHo95ls19KavaizXZTrqJu_pedNXssVEQtq3dHlTzOliA2N8Aw3DFl4LEJVWDV3CB-Xgl7CE2rqjuw2c523jTxJA-_BIgdkyuq2rGndJ0i9CqWqYeHxKPl8tPl2-98cyDL6Kedz7SunQWpEZAeCOqSgxDGJIaQSAB0AvOjUsE-HcGKNkqqRkioskiEBjSSq1ttEzctK0jXlB6BwXIRUgrkDJWCexlMZEWicYJkGj9UgwqaVUI0c5lspYlxCroCbL3zTpkXf7RzYDQcffOl-grvcdkVvbNYDFlaPFlf-yOI-cTpZSjgO-K8MMcDZDwOSRN_vbYAe4_iIa0-5cHwCcnAUgx_PBsPaSRClHarnAI-zI5I5EPb7TVN8cHfgcNxSziL38H3_uFbkfAozzXcbiKTnptzvzmtxV3_uq287I7WyVuSObkTsXi7z4OHMDD66K62Xx9Sf7VjoU |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VglQuvB-BAosEFySrjp_rA0KltGrUJIrUgnJz92WwFNshdkD8KPiNzPiRJoB664Gbtd61Rut57szOB_DKExEaBUnHSzqwPONwSwhfWjryIiPQYIWibpk_DMdjPp1Gky341d2FobLKTifWiloXis7I95wQHRlOFund_KtFqFGUXe0gNBq2ODE_vmPIVr4dfMD_-9pxjg7PDo6tFlXAUl7kVZZS2kkSERqBvgpXrm84hkTSCLSFaIx1YHgonL4xRslASclVJHzbjVTiB1LrxMXvXoPrqMdDCvbC6UWA10dr2GROXTey97IG4NaUlL10fAKuWbN9NUTAv_zaP8sz1-zd0e3_bafuwK3Ws2b7jSjchS2T34Odgw7Q7j78HIu6yQibYMSQFTpdZiwRMyoqX-DjoC1Ly9lplWaEamZKVuc42H5epbKgektWFWx0OumzwzmqwjkONDedE_TkWZqzEerdtS8R0tysZMs5Po-L3OoowPFmyYSKinSRpRldJmWfhFJpcz77AD5eyW49hO28yM1jYH3K1Sp0TG0lPe17Uhrjau1TNImDSQ_sjo9i1bZyJ0SRWYwhHbFe_Bfr9eDNasm86WNy2eT3xJyridSCvB4oFp_jVqPFXGpHJALppzMFbYskQIOhjJdQTGvcHux27Bm3erGML3izBy9Xr5EPKE0lclMs6znol0fcRjoeNZKwosQNIurAZ_eAb8jIBqmbb_L0S901vU_3rrnLn1xO1wvYOT4bDePhYHzyFG466NNadfnmLmxXi6V5BjfUtyotF89r2WdwftUi9BsunKOO |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Zb9NAEB6VFAEv3EegwCLBC5IVx1fWDwiVHiJqE1kqoPbJ7GWwFNshdkD8KP4Av44ZHyEB1Lc-8Gatd63Res6d2fkAnnsiRKMg6XhJB5ZnHG4J4UtLh15oBBqskahb5h-PplN-ehpGW_CzuwtDZZWdTqwVtS4UnZEPnBE6Mpws0iBpyyKi_cPX8y8WIUhRprWD02hY5Mh8_4bhW_lqvI__-oXjHB6823trtQgDlvJCr7KU0k6SiJER6Ldw5fqGY3gkjUC7iIZZB4aPhDM0xigZKCm5CoVvu6FK_EBqnbj43UuwjS655_RgOxpPorNVuDdE29jkUV03tAdZA3drSsplOj7B2KxZwhow4F9e7p_FmmvW7_DG_7xvN-F663Oz3UZIbsGWyW_D1b0O6u4O_JiKuv0IizCWyAqdLjOWiBmVmy_wcdwWrOXspEozwjszJauzH2w3r1JZUCUmqwo2OYmG7GCOSnKOA80d6AR9fJbmbIIaee1LhEE3K9lyjs_TIrc6CnC8WRJRuZEusjSja6bsg1AqbU5u78L7C9mte9DLi9w8ADakLK5Cl9VW0tO-J6UxrtY-xZk4mPTB7ngqVm2Td8IamcUY7BEbxn-xYR9erpbMmw4n501-Q4y6mkjNyeuBYvEpbnVdzKV2RCKQfjpt0LZIAjQlyngJRbvG7cNOx6pxqzHL-Def9uHZ6jXyASWwRG6KZT0HPfaQ20jH_UYqVpS4QUi9-ew-8A152SB1802efq77qQ_pRjZ3-cPz6XoKV1By4uPx9OgRXHPQ2bXqus4d6FWLpXkMl9XXKi0XT1pFwODjRcvQL6C4rd0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Natural+Plasmodium+falciparum+Infection+Stimulates+Human+Antibodies+to+MSP1+Epitopes+Identified+in+Mice+Infection+Models+upon+Non-Natural+Modified+Peptidomimetic+Vaccination&rft.jtitle=Molecules+%28Basel%2C+Switzerland%29&rft.au=Zully+Johana+Rodr%C3%ADguez&rft.au=Fredy+Leonardo+Melo&rft.au=Angela+Torres&rft.au=Nikhil+Agrawal&rft.date=2023-03-10&rft.pub=MDPI+AG&rft.eissn=1420-3049&rft.volume=28&rft.issue=6&rft.spage=2527&rft_id=info:doi/10.3390%2Fmolecules28062527&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_8bd2afa9cf6144d0af6030ce4f0642e3 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1420-3049&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1420-3049&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1420-3049&client=summon |