Genome-wide association study of pulpal and apical diseases

Infections of the dental pulp are common sequelae of microbial activity and host susceptibility, affecting >80% of adult population. We performed a genome-wide association study on endodontic infections utilizing Finnish health registry and genotype data from FinnGen. Cases [132,124 (27.2%)] had...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 6774 - 14
Main Authors:	Salminen, Aino, Hyvärinen, Kati, Ritari, Jarmo, Leppilahti, Jussi M., Palotie, Ulla, Vuollo, Ville, Kambur, Oleg, Reis, Kadri, Reigo, Anu, Palta, Priit, Perola, Markus, Sinisalo, Juha, Havulinna, Aki S., Mäntylä, Päivi, Gürsoy, Ulvi Kahraman, Suominen, A. Liisa, Rice, David P., Anttonen, Vuokko, Nieminen, Pekka, Pussinen, Pirkko J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.07.2025 Nature Publishing Group Nature Portfolio
Subjects:	45/43 692/308/2056 692/699/3017/3019 Adult Alleles Antigen processing Biological activity Case-Control Studies Chromosomes Codes Complications Dental pulp Diagnosis Drb1 protein Endodontics Female Finland Genes Genetic diversity Genetic Predisposition to Disease Genetic variance Genome-wide association studies Genome-Wide Association Study Genomes Genotype Genotype & phenotype Genotypes Gum disease Histocompatibility antigen HLA HLA-DQ beta-Chains - genetics HLA-DRB1 Chains - genetics Humanities and Social Sciences Humans Immune response (humoral) Immunogenetics Infections Major histocompatibility complex Male Males Microbial activity Microorganisms Middle Aged multidisciplinary Necrosis Pathogenesis Periapical Periodontitis - genetics Periapical Periodontitis - immunology Periodontitis Phenotypes Polymorphism, Single Nucleotide Pulpitis - genetics Pulpitis - immunology Science Science (multidisciplinary) Young Adult Finland
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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