Differences between suspected keratoconus and subclinical keratoconus via multiparameter analysis in Chinese populations

Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study...

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Veröffentlicht in:	Scientific reports Jg. 15; H. 1; S. 12412 - 10
Hauptverfasser:	Peng, Yusu, Feng, Qingqing, Shao, Ting, Zhang, Jiafan, Liu, Sai, Wang, Huifeng, Li, Hua, Long, Keli
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 11.04.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	692/308 692/499 692/699 Adolescent Adult China - epidemiology Cornea Cornea - pathology Corneal diameter Corneal Topography - methods Cross-Sectional Studies East Asian People Eye surgery Female Humanities and Social Sciences Humans I-S value Keratoconus Keratoconus - diagnosis Keratoconus - epidemiology Keratoconus - pathology Male Middle Aged multidisciplinary Prediction model Prediction models Regression analysis ROC Curve Science Science (multidisciplinary) Subclinical keratoconus Surgery Suspected keratoconus Young Adult China Subclinical keratoconus Suspected keratoconus Corneal diameter I-S value Prediction model
ISSN:	2045-2322, 2045-2322
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Abstract	Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) ( P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety.
AbstractList	Abstract Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) ( P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety.Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety.
ArticleNumber	12412
Author	Zhang, Jiafan Feng, Qingqing Li, Hua Liu, Sai Shao, Ting Peng, Yusu Wang, Huifeng Long, Keli
Author_xml	– sequence: 1 givenname: Yusu surname: Peng fullname: Peng, Yusu organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 2 givenname: Qingqing surname: Feng fullname: Feng, Qingqing organization: Qingdao Central Hospital, University of Health and Rehabilitation Sciences – sequence: 3 givenname: Ting surname: Shao fullname: Shao, Ting organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 4 givenname: Jiafan surname: Zhang fullname: Zhang, Jiafan organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 5 givenname: Sai surname: Liu fullname: Liu, Sai organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 6 givenname: Huifeng surname: Wang fullname: Wang, Huifeng organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 7 givenname: Hua surname: Li fullname: Li, Hua organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 8 givenname: Keli surname: Long fullname: Long, Keli email: longkeli2002@aliyun.com organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University
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Keywords	Subclinical keratoconus Suspected keratoconus Corneal diameter I-S value Prediction model
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Snippet	Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the... Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the... Abstract Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of...
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SubjectTerms	692/308 692/499 692/699 Adolescent Adult China - epidemiology Cornea Cornea - pathology Corneal diameter Corneal Topography - methods Cross-Sectional Studies East Asian People Eye surgery Female Humanities and Social Sciences Humans I-S value Keratoconus Keratoconus - diagnosis Keratoconus - epidemiology Keratoconus - pathology Male Middle Aged multidisciplinary Prediction model Prediction models Regression analysis ROC Curve Science Science (multidisciplinary) Subclinical keratoconus Surgery Suspected keratoconus Young Adult
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Title	Differences between suspected keratoconus and subclinical keratoconus via multiparameter analysis in Chinese populations
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