Differences between suspected keratoconus and subclinical keratoconus via multiparameter analysis in Chinese populations
Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study...
Uloženo v:
| Vydáno v: | Scientific reports Ročník 15; číslo 1; s. 12412 - 10 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
11.04.2025
Nature Publishing Group Nature Portfolio |
| Témata: | |
| ISSN: | 2045-2322, 2045-2322 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (
P
< 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. |
|---|---|
| AbstractList | Abstract Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) ( P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety.Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. All the Chinese subjects were examined via the Pentacam and Corvis ST (Oculus, Wetzlar, Germany). The 90 parameters of the Belin/Ambrósio System, Topometric/KC System, and Corvis ST System were extracted from internal CSV files and analyzed. The differences in all the parameters between the two groups were compared, and ROC curves were created. LASSO regression was employed to simplify the number of parameters, and a logistic regression model was constructed for KC prediction. The suspected KC group, in contrast to the subclinical KC group, predominantly consisted of females and older patients. The highest AUC parameters of the three systems were PachyProgIndexMax [0.896 (0.839, 0.954), cutoff = 1.445], IHD [0.787 (0.691, 0.883), cutoff = 0.029], SPA1 [0.811 (0.718, 0.904), cutoff = 87.485]. For the first discovery, the corneal diameter in the suspected KC group (11.56 ± 0.38) was smaller than that in the subclinical KC group (11.91 ± 0.33) (P < 0.05) [AUC = 0.736 (0.641, 0.832), cutoff = 11.825]. Seven relevant parameters were identified via LASSO regression (AUC = 0.954), including IHD, Cornea Diameter, DARatioMax_2 mm, BADDy, BADD, PachyProgIndexMax, and CBI. The prediction accuracy of the logistic regression model was 0.902 (AUC = 0.964). Our model effectively predicts an elevated risk of suspected KC to subclinical KC and even KC in younger Chinese men, particularly those exhibiting increased corneal diameter and morphological and biomechanical parameters. This model might help with screening for preoperative refractive surgery, thereby improving surgical safety. |
| ArticleNumber | 12412 |
| Author | Zhang, Jiafan Feng, Qingqing Li, Hua Liu, Sai Shao, Ting Peng, Yusu Wang, Huifeng Long, Keli |
| Author_xml | – sequence: 1 givenname: Yusu surname: Peng fullname: Peng, Yusu organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 2 givenname: Qingqing surname: Feng fullname: Feng, Qingqing organization: Qingdao Central Hospital, University of Health and Rehabilitation Sciences – sequence: 3 givenname: Ting surname: Shao fullname: Shao, Ting organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 4 givenname: Jiafan surname: Zhang fullname: Zhang, Jiafan organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 5 givenname: Sai surname: Liu fullname: Liu, Sai organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 6 givenname: Huifeng surname: Wang fullname: Wang, Huifeng organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 7 givenname: Hua surname: Li fullname: Li, Hua organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University – sequence: 8 givenname: Keli surname: Long fullname: Long, Keli email: longkeli2002@aliyun.com organization: Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40216806$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kk1v1DAQhiNUREvpH-CAInHhErAdO7FPCC1flSpxgbM1ccZbL4kd7KRl_z2mWUqXAz7YI88z74zs92lx4oPHonhOyWtKavkmcSqUrAgTlSKENdX-UXHGCBcVqxk7eRCfFhcp7UhegilO1ZPilBNGG0mas-Lne2ctRvQGU9nhfIvoy7SkCc2MffkdI8zBBL-kEnyfM50ZnHcGhqPcjYNyXIbZTRBhxBljxmHYJ5dK58vNtfOYsJzCtAwwu-DTs-KxhSHhxeE8L759_PB187m6-vLpcvPuqjJc8bkCaQ1rjBS2y1vdGWGJ6XuqKCUIlGMNnHCpaiVpz6xoqWW8lhLBEobW1OfF5arbB9jpKboR4l4HcPruIsSthjg7M6CWtuMWc5-uabloheqyXN9w0QCIWoms9XbVmpZuxN6gnyMMR6LHGe-u9TbcaEqVYpTQrPDqoBDDjwXTrEeXDA4DeAxL0jWVioq2bVRGX_6D7sIS86MeKEIaIjP14uFI97P8-eEMsBUwMaQU0d4jlOjfTtKrk3R2kr5zkt7nonotShn2W4x_e_-n6hci6M6l |
| Cites_doi | 10.1136/bjo.2008.140012 10.1016/j.jcrs.2006.11.008 10.3928/15428877-20120102-03 10.1038/s41598-022-09160-6 10.1155/2018/7875148 10.1016/j.jcrs.2003.10.012 10.1155/2015/294197 10.1097/ICO.0000000000000408 10.1111/j.2517-6161.1996.tb02080.x 10.1007/s00276-011-0889-4 10.1097/ICO.0000000000002896 10.1016/j.survophthal.2018.05.004 10.1016/j.jcrs.2014.04.013 10.1016/j.ajo.2013.03.034 10.3928/1081597X-20180124-01 10.3928/1081597X-20200730-02 10.1136/bjo.2008.147371 10.3928/1081597X-20091209-07 10.1038/s41598-024-72054-2 10.1002/jbio.201500236 10.1016/s0886-3350(99)00195-9 10.1159/000146512 10.1186/s12886-021-02102-2 10.3928/1081597X-20210330-01 10.1016/j.jcrs.2014.05.052 10.3389/fmed.2021.732719 10.1080/08820538.2021.1896752 10.1186/s40662-020-00225-z 10.1155/2015/925414 10.1016/j.ajo.2018.08.005 10.3389/fbioe.2023.1158299 10.1111/j.1444-0938.2004.tb03155.x 10.1016/j.ajo.2022.12.016 10.1186/s12886-017-0584-2 10.1016/j.ajo.2014.03.018 10.1155/2019/1748579 10.3928/1081597X-20130719-06 10.1167/iovs.13-13715 10.3928/1081597X-20200212-03 10.3389/fmed.2022.834663 10.3389/fbioe.2022.839545 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2025 2025. The Author(s). Copyright Nature Publishing Group 2025 The Author(s) 2025 2025 |
| Copyright_xml | – notice: The Author(s) 2025 – notice: 2025. The Author(s). – notice: Copyright Nature Publishing Group 2025 – notice: The Author(s) 2025 2025 |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-025-90026-y |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 10 |
| ExternalDocumentID | oai_doaj_org_article_8fb4febc8b6745759b571d6456aa5395 PMC11992101 40216806 10_1038_s41598_025_90026_y |
| Genre | Journal Article |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GrantInformation_xml | – fundername: Department of Health of Shandong Province grantid: 202107020443; 202107020443; 202107020443; 202107020443; 202107020443; 202107020443; 202107020443; 202107020443 funderid: http://dx.doi.org/10.13039/501100010669 – fundername: Department of Health of Shandong Province grantid: 202107020443 |
| GroupedDBID | 0R~ 4.4 53G 5VS 7X7 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD AASML ABDBF ABUWG ACGFS ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AFPKN AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M1P M2P M7P M~E NAO OK1 PHGZT PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AAYXX AFFHD CITATION PHGZM PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM PUEGO 3V. 7XB 88A 8FK K9. M48 PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c494t-a8fc26c85fbc853bc5f0cdd19110ea14e3a404893981d2f571f24388eaf02efc3 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 1 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001465574200003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2045-2322 |
| IngestDate | Mon Nov 10 04:32:29 EST 2025 Tue Nov 04 02:04:52 EST 2025 Sat Nov 01 14:27:11 EDT 2025 Tue Oct 07 09:05:16 EDT 2025 Thu Aug 28 04:47:38 EDT 2025 Sat Nov 29 08:05:11 EST 2025 Sat Apr 12 01:21:50 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Subclinical keratoconus Suspected keratoconus Corneal diameter I-S value Prediction model |
| Language | English |
| License | 2025. The Author(s). Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c494t-a8fc26c85fbc853bc5f0cdd19110ea14e3a404893981d2f571f24388eaf02efc3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.proquest.com/docview/3189100608?pq-origsite=%requestingapplication% |
| PMID | 40216806 |
| PQID | 3189100608 |
| PQPubID | 2041939 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8fb4febc8b6745759b571d6456aa5395 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11992101 proquest_miscellaneous_3189157769 proquest_journals_3189100608 pubmed_primary_40216806 crossref_primary_10_1038_s41598_025_90026_y springer_journals_10_1038_s41598_025_90026_y |
| PublicationCentury | 2000 |
| PublicationDate | 2025-04-11 |
| PublicationDateYYYYMMDD | 2025-04-11 |
| PublicationDate_xml | – month: 04 year: 2025 text: 2025-04-11 day: 11 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2025 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | YS Rabinowitz (90026_CR19) 1999; 25 L Ding (90026_CR32) 2020; 36 L Hu (90026_CR18) 2021; 37 JA Gomes (90026_CR20) 2015; 34 A Luz (90026_CR7) 2016; 9 M Shirayama-Suzuki (90026_CR4) 2009; 93 90026_CR39 JF Alfonso (90026_CR28) 2010; 26 NQ Ali (90026_CR12) 2014; 55 H Hashemi (90026_CR25) 2022; 41 D Smadja (90026_CR17) 2013; 156 BT Lopes (90026_CR41) 2018; 195 90026_CR13 Y Liu (90026_CR35) 2021; 21 P Song (90026_CR15) 2022; 12 Y Li (90026_CR34) 2021; 8 Y Guo (90026_CR38) 2024; 14 K Shirama (90026_CR31) 1988; 131 J Ma (90026_CR9) 2018; 63 O Muftuoglu (90026_CR8) 2015; 41 MA Henriquez (90026_CR3) 2020; 36 G Nemeth (90026_CR11) 2013; 29 M Shajari (90026_CR27) 2018; 34 EA Awad (90026_CR22) 2017; 17 X Zhang (90026_CR14) 2022; 10 PR Ruiseñor Vázquez (90026_CR23) 2014; 158 G Xu (90026_CR30) 2021; 8 90026_CR26 CJ Roberts (90026_CR10) 2014; 40 90026_CR24 LL Guo (90026_CR36) 2021; 36 B Qin (90026_CR33) 2012; 43 R Vinciguerra (90026_CR37) 2022; 9 90026_CR40 S Klyce (90026_CR2) 2009; 93 PS Binder (90026_CR1) 2003; 29 F Orucoglu (90026_CR6) 2015; 2015 X Chen (90026_CR16) 2023; 11 JA Sanchis-Gimeno (90026_CR29) 2012; 34 D Chen (90026_CR5) 2007; 33 JS Saini (90026_CR21) 2004; 87 |
| References_xml | – volume: 93 start-page: 815 issue: 6 year: 2009 ident: 90026_CR4 publication-title: Br. J. Ophthalmol. doi: 10.1136/bjo.2008.140012 – volume: 33 start-page: 448 issue: 3 year: 2007 ident: 90026_CR5 publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2006.11.008 – volume: 43 start-page: 135 issue: 2 year: 2012 ident: 90026_CR33 publication-title: Ophthalmic Surg. Lasers Imaging: Official J. Int. Soc. Imaging Eye doi: 10.3928/15428877-20120102-03 – volume: 12 start-page: 5316 issue: 1 year: 2022 ident: 90026_CR15 publication-title: Sci. Rep. doi: 10.1038/s41598-022-09160-6 – ident: 90026_CR26 doi: 10.1155/2018/7875148 – volume: 29 start-page: 2419 issue: 12 year: 2003 ident: 90026_CR1 publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2003.10.012 – ident: 90026_CR13 doi: 10.1155/2015/294197 – volume: 34 start-page: 359 issue: 4 year: 2015 ident: 90026_CR20 publication-title: Cornea doi: 10.1097/ICO.0000000000000408 – ident: 90026_CR39 doi: 10.1111/j.2517-6161.1996.tb02080.x – volume: 34 start-page: 167 issue: 2 year: 2012 ident: 90026_CR29 publication-title: Surg. Radiologic Anatomy: SRA doi: 10.1007/s00276-011-0889-4 – volume: 41 start-page: 450 issue: 4 year: 2022 ident: 90026_CR25 publication-title: Cornea doi: 10.1097/ICO.0000000000002896 – volume: 63 start-page: 851 issue: 6 year: 2018 ident: 90026_CR9 publication-title: Surv. Ophthalmol. doi: 10.1016/j.survophthal.2018.05.004 – volume: 40 start-page: 991 issue: 6 year: 2014 ident: 90026_CR10 publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2014.04.013 – volume: 156 start-page: 237 issue: 2 year: 2013 ident: 90026_CR17 publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2013.03.034 – volume: 34 start-page: 254 issue: 4 year: 2018 ident: 90026_CR27 publication-title: J. Refractive Surg. (Thorofare N J. : 1995) doi: 10.3928/1081597X-20180124-01 – volume: 36 start-page: 688 issue: 10 year: 2020 ident: 90026_CR32 publication-title: J. Refractive Surg. (Thorofare N J. : 1995) doi: 10.3928/1081597X-20200730-02 – volume: 93 start-page: 845 issue: 7 year: 2009 ident: 90026_CR2 publication-title: Br. J. Ophthalmol. doi: 10.1136/bjo.2008.147371 – volume: 26 start-page: 891 issue: 11 year: 2010 ident: 90026_CR28 publication-title: J. Refractive Surg. (Thorofare N J. : 1995) doi: 10.3928/1081597X-20091209-07 – volume: 14 start-page: 21713 issue: 1 year: 2024 ident: 90026_CR38 publication-title: Sci. Rep. doi: 10.1038/s41598-024-72054-2 – volume: 9 start-page: 445 issue: 5 year: 2016 ident: 90026_CR7 publication-title: J. Biophotonics doi: 10.1002/jbio.201500236 – volume: 25 start-page: 1327 issue: 10 year: 1999 ident: 90026_CR19 publication-title: J. Cataract Refract. Surg. doi: 10.1016/s0886-3350(99)00195-9 – volume: 131 start-page: 192 issue: 3 year: 1988 ident: 90026_CR31 publication-title: Acta Anat. doi: 10.1159/000146512 – volume: 21 start-page: 339 issue: 1 year: 2021 ident: 90026_CR35 publication-title: BMC Ophthalmol. doi: 10.1186/s12886-021-02102-2 – volume: 37 start-page: 438 issue: 7 year: 2021 ident: 90026_CR18 publication-title: J. Refractive Surg. (Thorofare N J. : 1995) doi: 10.3928/1081597X-20210330-01 – volume: 41 start-page: 557 issue: 3 year: 2015 ident: 90026_CR8 publication-title: J. Cataract Refract. Surg. doi: 10.1016/j.jcrs.2014.05.052 – volume: 8 start-page: 732719 year: 2021 ident: 90026_CR30 publication-title: Front. Med. doi: 10.3389/fmed.2021.732719 – volume: 36 start-page: 671 issue: 8 year: 2021 ident: 90026_CR36 publication-title: Semin. Ophthalmol. doi: 10.1080/08820538.2021.1896752 – volume: 8 start-page: 2 issue: 1 year: 2021 ident: 90026_CR34 publication-title: Eye Vis. (London England) doi: 10.1186/s40662-020-00225-z – volume: 2015 start-page: 925414 year: 2015 ident: 90026_CR6 publication-title: J. Ophthalmol. doi: 10.1155/2015/925414 – volume: 195 start-page: 223 year: 2018 ident: 90026_CR41 publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2018.08.005 – volume: 11 start-page: 1158299 year: 2023 ident: 90026_CR16 publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2023.1158299 – volume: 87 start-page: 97 issue: 2 year: 2004 ident: 90026_CR21 publication-title: Clin. Experimental Optometry doi: 10.1111/j.1444-0938.2004.tb03155.x – ident: 90026_CR40 doi: 10.1016/j.ajo.2022.12.016 – volume: 17 start-page: 186 issue: 1 year: 2017 ident: 90026_CR22 publication-title: BMC Ophthalmol. doi: 10.1186/s12886-017-0584-2 – volume: 158 start-page: 32 issue: 1 year: 2014 ident: 90026_CR23 publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2014.03.018 – ident: 90026_CR24 doi: 10.1155/2019/1748579 – volume: 29 start-page: 558 issue: 8 year: 2013 ident: 90026_CR11 publication-title: J. Refractive Surg. (Thorofare N J. : 1995) doi: 10.3928/1081597X-20130719-06 – volume: 55 start-page: 3651 issue: 6 year: 2014 ident: 90026_CR12 publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.13-13715 – volume: 36 start-page: 270 issue: 4 year: 2020 ident: 90026_CR3 publication-title: J. Refractive Surg. (Thorofare N J. : 1995) doi: 10.3928/1081597X-20200212-03 – volume: 9 start-page: 834663 year: 2022 ident: 90026_CR37 publication-title: Front. Med. doi: 10.3389/fmed.2022.834663 – volume: 10 start-page: 839545 year: 2022 ident: 90026_CR14 publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2022.839545 |
| SSID | ssj0000529419 |
| Score | 2.4528682 |
| Snippet | Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of the... Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient's vision. To improve the safety of the... Abstract Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause serious damage to the patient’s vision. To improve the safety of... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 12412 |
| SubjectTerms | 692/308 692/499 692/699 Adolescent Adult China - epidemiology Cornea Cornea - pathology Corneal diameter Corneal Topography - methods Cross-Sectional Studies East Asian People Eye surgery Female Humanities and Social Sciences Humans I-S value Keratoconus Keratoconus - diagnosis Keratoconus - epidemiology Keratoconus - pathology Male Middle Aged multidisciplinary Prediction model Prediction models Regression analysis ROC Curve Science Science (multidisciplinary) Subclinical keratoconus Surgery Suspected keratoconus Young Adult |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9UwDLfQBBIXNL7LBgoSN6jWpEmaHLfBxGniANJuUZoP8YTUN63vTXv_PU7S97byIS5c67RybSe2FftngHfKxRi407WSjmGCEmitg6a1pzaKtu8d82XYRHd-ri4u9Jc7o75STViBBy6CO1Kx5zH0TvWy42maZC866iX6fWtFqzN6KUY9d5KpgurNNKd66pJpWnU0oqdK3WRM1DolHvVm5okyYP-foszfiyV_uTHNjuhsHx5NESQ5Lpw_hntheAIPykzJzVO4-TiNPMEDgExVWGRc547K4MmPBKK8xCR4PRI7eKT02-bIGe16YUkpNrSpfAulj8sLfglZDCSN3Q5jIJe7-V_jM_h29unr6ed6Gq9QO675qrYqOiadEhGli3pxIjbOe0zgaBMs5aG1vEnYNBpjWhZR7JHxVqlgY8NCdO1z2BuWQ3gJhHadjBS_Y_GdKLxWwkcpEngdU1KLCt5vRW0uC4qGybffrTJFMQYVY7JizKaCk6SN3cqEgJ0foF2YyS7Mv-yigsOtLs20LUeDBxiGR41sVAVvd2TcUOmWxA5huZ7WCPwhXcGLovodJ5hsU6kaWYGaGcWM1TllWHzPoN001fni-VfBh6393PL1d1m8-h-yOICHLBl-gqikh7C3ulqH13DfXa8W49WbvHN-ApeaH9Y priority: 102 providerName: Directory of Open Access Journals |
| Title | Differences between suspected keratoconus and subclinical keratoconus via multiparameter analysis in Chinese populations |
| URI | https://link.springer.com/article/10.1038/s41598-025-90026-y https://www.ncbi.nlm.nih.gov/pubmed/40216806 https://www.proquest.com/docview/3189100608 https://www.proquest.com/docview/3189157769 https://pubmed.ncbi.nlm.nih.gov/PMC11992101 https://doaj.org/article/8fb4febc8b6745759b571d6456aa5395 |
| Volume | 15 |
| WOSCitedRecordID | wos001465574200003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M7P dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M2P dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwEB6xLUh74f0ILFWQuEG0cRIn9gmxsCs4bBUhkMopchx7qZCSbtOu6L9nJnG6Cq8LlznUbjLOzNgez_gbgJdCW2sSLQOR6ggdFMMCaSQLKqYsj8tSR1VfbCKbz8ViIXN34Na6tMphTuwm6qrRdEZ-jLqHK1uYhuLN6jKgqlEUXXUlNA5gSkhlyQSmJ6fz_NP-lIXiWAmT7rZMGIvjFlcsulUW8UCSAxLsRitSB9z_p93m70mTv0ROuwXp7M7_DuUu3HZbUf9trzv34Iap78Otvjjl7gH8eO9qp-BM4rt0Lr_ddlczTeV_JzTmBr3pbeurusKWcrhlOWq7Wiq_z1pUlAeGYsTuPRCKv6x9qt9tWuOv9oXE2ofw5ez087sPgavTEOhEJptACaujVAtuSyRxqbkNdVWhJ8hCo1hiYpWEBHIjcXMcWZ4xGyWxEEbZMDJWx49gUje1eQI-y7LUMnyOwv9YXknBK5tyQsGLRCq5B68GWRWrHo6j6MLosSh6yRYo2aKTbLHz4ITEue9JUNrdD836onCWWQhbJtYg52WaJVSutEQGqxQ3lkrxmF55NEixcPbdFtci9ODFvhktk8ItqjbN1vXhOCDpweNed_acoNfOUhGmHoiRVo1YHbfUy28d-jejhGGcSD14PSjgNV9__xZP_z2MZ3AYkU0QiiU7gslmvTXP4aa-2izb9QwOskXWUTFzJjbrTi-Qnkc50QzpNP94nn_9CSWINaE |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoIL70eggJHgBFFjJ07sA0JAqVq1rDgUaW_GcWy6qpQsm93C_il-I-O8qvC69cAlh9hJxsnnmXE8Mx_AM2Gcs4mRoUgNwwWKpaG0koYF1Y7HeW5Y0ZJNZJOJmE7lxw340efC-LDKXic2irqojP9Hvo3YQ8sWpZF4Pf8aetYov7vaU2i0sDiw62-4ZKtf7e_g933O2O77o3d7YccqEJpEJstQC2dYagR3OR7i3HAXmaLAdQuNrKaJjXUS-ZIsEl055nhGHUtiIax2EbPOxHjfC3AR9XjmQ8iyaTb80_G7ZgmVXW5OFIvtGu2jz2FjPJR-uROuR_avoQn4k2_7e4jmL_u0jfnbvf6_vbgbcK1ztMmbdmbchA1b3oLLLfXm-jZ83-mYYVBPki5YjdSrJvHUFuTE15quTFWuaqLLAlvyPod01HY606SNydQ-yg1Bit3bMi9kVhLPTm5rS-YDTVp9Bz6dy7DvwmZZlfY-EJplqaN4H43XOF5IwQuXcl_jj4lU8gBe9NhQ87bYiGqCBGKhWiQpRJJqkKTWAbz18Bl6-kLhzYlq8UV1ekcJlyfOouR5miWejDVHAYsU3WateewfudWjRnXaq1ZnkAng6dCMesdvJunSVquuD8cByQDutVgdJEnQcUxFlAYgRigeiTpuKWfHTW1z6sOh0UwE8LIH_Jlcf38XD_49jCdwZe_ow6E63J8cPISrzM9HX6-TbsHmcrGyj-CSOV3O6sXjZkIT-HzeE-EnOJWLrA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lj9MwEB4ty0NceD8CCxgJThA1duLEPiAElIrVQtUDSHszjmOz1UpJadqF_jV-HeO8VuV12wOXHmo3HSffPBzPzAfwRBjnbGJkKFLDcINiaSitpGFBteNxnhtWtGQT2XQqDg_lbAd-9LUwPq2yt4mNoS4q49-RjxB76NmiNBIj16VFzMaTl4uvoWeQ8ietPZ1GC5EDu_mG27f6xf4Yn_VTxiZvP755F3YMA6FJZLIKtXCGpUZwl-NHnBvuIlMUuIehkdU0sbFOIt-eRWJYxxzPqGNJLITVLmLWmRivew7OZwnnXrs-sNnwfsefoCVUdnU6USxGNfpKX8_GeCj91ifcbPnChjLgT3Hu7-mav5zZNq5wcvV_vonX4EoXgJNXrcZchx1b3oCLLSXn5iZ8H3eMMWg_SZfERup1U5BqC3Lse1BXpirXNdFlgSN5X1u6NXYy16TN1dQ--w3Bi9Pb9i9kXhLPWm5rSxYDfVp9Cz6dybJvw25ZlfYuEJplqaN4HY2_cbyQghcu5b73HxOp5AE863GiFm0TEtUkD8RCtahSiCrVoEptAnjtoTTM9A3Emy-q5RfV2SMlXJ44i5LnKaI34zJHAYsUw2mteez_cq9HkOqsWq1O4RPA42EY7ZE_ZNKlrdbdHI4LkgHcaXE7SJJgQJmKKA1AbCF6S9TtkXJ-1PQ8pz5NGt1HAM978J_K9fd7ce_fy3gElxD_6v3-9OA-XGZeNX0bT7oHu6vl2j6AC-ZkNa-XDxvdJvD5rPXgJ8IslHk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Differences+between+suspected+keratoconus+and+subclinical+keratoconus+via+multiparameter+analysis+in+Chinese+populations&rft.jtitle=Scientific+reports&rft.au=Peng%2C+Yusu&rft.au=Feng%2C+Qingqing&rft.au=Shao%2C+Ting&rft.au=Zhang%2C+Jiafan&rft.date=2025-04-11&rft.issn=2045-2322&rft.eissn=2045-2322&rft.volume=15&rft.issue=1&rft.spage=12412&rft_id=info:doi/10.1038%2Fs41598-025-90026-y&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |