Overexpression of POLQ confers a poor prognosis in early breast cancer patients

Depletion of POLQ (DNA polymerase theta) has recently been shown to render tumour cells more sensitive to radiotherapy whilst having little or no effect on normal tissues. This finding led us to investigate whether tumours that overexpress POLQ are associated with an adverse outcome. We therefore co...

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Vydáno v:	Oncotarget Ročník 1; číslo 3; s. 175
Hlavní autoři:	Higgins, Geoff S, Harris, Adrian L, Prevo, Remko, Helleday, Thomas, McKenna, W Gillies, Buffa, Francesca M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2010
Témata:	Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - therapy Disease Progression DNA Polymerase theta DNA Repair - genetics DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Female Follow-Up Studies Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Microarray Analysis Middle Aged Molecular Targeted Therapy Prognosis Radiation Tolerance - drug effects Treatment Outcome radiotherapy POLQ breast cancer Translational research prognosis
ISSN:	1949-2553, 1949-2553
On-line přístup:	Zjistit podrobnosti o přístupu
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