Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study

Gut microbes are crucial to human health, but microbial composition is often disturbed in a number of human diseases. Accumulating evidence points to nutritional modulation of the gut microbiota as a potentially beneficial therapeutic strategy. Vitamin C (ascorbic acid) may be of particular interest...

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Vydané v:Antioxidants Ročník 10; číslo 8; s. 1278
Hlavní autori: Otten, Antonius T., Bourgonje, Arno R., Peters, Vera, Alizadeh, Behrooz Z., Dijkstra, Gerard, Harmsen, Hermie J. M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Basel MDPI AG 12.08.2021
MDPI
Predmet:
Anti-inflammatory agents
antioxidant
Antioxidants
Ascorbic acid
Bacteria
Bacteroidetes
Body mass index
Dietary supplements
digestive system
Enterococcus
Gemmiger formicilis
genes
Genetic testing
gut microbiome
human health
humans
Inflammation
Intestinal microflora
intestinal microorganisms
Lachnospiraceae
Microbiota
micronutrient
Oxidative stress
pilot study
Prebiotics
rRNA 16S
Small intestine
Streptococcus thermophilus
therapeutics
Vitamin C
United States > US
ISSN:2076-3921, 2076-3921
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Shrnutí:Gut microbes are crucial to human health, but microbial composition is often disturbed in a number of human diseases. Accumulating evidence points to nutritional modulation of the gut microbiota as a potentially beneficial therapeutic strategy. Vitamin C (ascorbic acid) may be of particular interest as it has known antioxidant and anti-inflammatory properties. In this study, we investigated whether supplementation with high-dose vitamin C may favourably affect the composition of the gut microbiota. In this pilot study, healthy human participants received 1000 mg vitamin C supplementation daily for two weeks. Gut microbiota composition was analysed before and after intervention by performing faecal 16S rRNA gene sequencing. In total, 14 healthy participants were included. Daily supplementation of high-dose vitamin C led to an increase in the relative abundances of Lachnospiraceae (p < 0.05), whereas decreases were observed for Bacteroidetes (p < 0.01), Enterococci (p < 0.01) and Gemmiger formicilis (p < 0.05). In addition, trends for bacterial shifts were observed for Blautia (increase) and Streptococcus thermophilus (decrease). High-dose vitamin C supplementation for two weeks shows microbiota-modulating effects in healthy individuals, with several beneficial shifts of bacterial populations. This may be relevant as these bacteria have anti-inflammatory properties and strongly associate with gut health.
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These authors contributed equally to this work.
Authors share senior authorship.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10081278