Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates proinflammatory and proatherogenic compounds in the arterial vascular wall and is a potential therapeutic target in coronary heart disease (CHD). We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association...

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Vydáno v:	European heart journal Ročník 33; číslo 2; s. 238
Hlavní autoři:	Grallert, Harald, Dupuis, Josée, Bis, Joshua C, Dehghan, Abbas, Barbalic, Maja, Baumert, Jens, Lu, Chen, Smith, Nicholas L, Uitterlinden, André G, Roberts, Robert, Khuseyinova, Natalie, Schnabel, Renate B, Rice, Kenneth M, Rivadeneira, Fernando, Hoogeveen, Ron C, Fontes, João Daniel, Meisinger, Christa, Keaney, Jr, John F, Lemaitre, Rozenn, Aulchenko, Yurii S, Vasan, Ramachandran S, Ellis, Stephen, Hazen, Stanley L, van Duijn, Cornelia M, Nelson, Jeanenne J, März, Winfried, Schunkert, Heribert, McPherson, Ruth M, Stirnadel-Farrant, Heide A, Psaty, Bruce M, Gieger, Christian, Siscovick, David, Hofman, Albert, Illig, Thomas, Cushman, Mary, Yamamoto, Jennifer F, Rotter, Jerome I, Larson, Martin G, Stewart, Alexandre F R, Boerwinkle, Eric, Witteman, Jacqueline C M, Tracy, Russell P, Koenig, Wolfgang, Benjamin, Emelia J, Ballantyne, Christie M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.01.2012
Témata:	1-Alkyl-2-acetylglycerophosphocholine Esterase Aged Coronary Artery Disease - genetics Coronary Disease - genetics Female Genetic Loci - genetics Genome-Wide Association Study Humans Male Middle Aged Phospholipases A2 - genetics Polymorphism, Single Nucleotide - genetics
ISSN:	1522-9645, 1522-9645
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