Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates proinflammatory and proatherogenic compounds in the arterial vascular wall and is a potential therapeutic target in coronary heart disease (CHD). We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association...

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Published in:	European heart journal Vol. 33; no. 2; p. 238
Main Authors:	Grallert, Harald, Dupuis, Josée, Bis, Joshua C, Dehghan, Abbas, Barbalic, Maja, Baumert, Jens, Lu, Chen, Smith, Nicholas L, Uitterlinden, André G, Roberts, Robert, Khuseyinova, Natalie, Schnabel, Renate B, Rice, Kenneth M, Rivadeneira, Fernando, Hoogeveen, Ron C, Fontes, João Daniel, Meisinger, Christa, Keaney, Jr, John F, Lemaitre, Rozenn, Aulchenko, Yurii S, Vasan, Ramachandran S, Ellis, Stephen, Hazen, Stanley L, van Duijn, Cornelia M, Nelson, Jeanenne J, März, Winfried, Schunkert, Heribert, McPherson, Ruth M, Stirnadel-Farrant, Heide A, Psaty, Bruce M, Gieger, Christian, Siscovick, David, Hofman, Albert, Illig, Thomas, Cushman, Mary, Yamamoto, Jennifer F, Rotter, Jerome I, Larson, Martin G, Stewart, Alexandre F R, Boerwinkle, Eric, Witteman, Jacqueline C M, Tracy, Russell P, Koenig, Wolfgang, Benjamin, Emelia J, Ballantyne, Christie M
Format:	Journal Article
Language:	English
Published:	England 01.01.2012
Subjects:	1-Alkyl-2-acetylglycerophosphocholine Esterase Aged Coronary Artery Disease - genetics Coronary Disease - genetics Female Genetic Loci - genetics Genome-Wide Association Study Humans Male Middle Aged Phospholipases A2 - genetics Polymorphism, Single Nucleotide - genetics
ISSN:	1522-9645, 1522-9645
Online Access:	Get more information
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