Differences in the levels of inflammatory markers between metabolically healthy obese and other obesity phenotypes in adults: A systematic review and meta-analysis

The aim of this study was to systematically review and analyze differences in the levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) comparing metabolically healthy but obese (MHO) with metabolically healthy non-obese (MHNO), metabolically unhealthy non...

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Vydané v:Nutrition, metabolism, and cardiovascular diseases Ročník 34; číslo 2; s. 251 - 269
Hlavní autori: Su, Zhouli, Efremov, Ljupcho, Mikolajczyk, Rafael
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier B.V 01.02.2024
Predmet:
Adult
Body Mass Index
C-reactive protein
Humans
Inflammation
Interleukin-6
meta-analysis
Metabolic Syndrome
Metabolically healthy obese
metabolism
nutrition
obesity
Obesity - diagnosis
Obesity, Metabolically Benign - diagnosis
Obesity, Morbid
Phenotype
Risk Factors
statistical models
systematic review
Tumor Necrosis Factor-alpha
Metabolically healthy obese
Tumor necrosis factor-alpha
Inflammation
C-reactive protein
Interleukin-6
ISSN:0939-4753, 1590-3729, 1590-3729
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Shrnutí:The aim of this study was to systematically review and analyze differences in the levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) comparing metabolically healthy but obese (MHO) with metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO) subjects. We searched PubMed, Embase, Web of Science, and Scopus for studies that matched the relevant search terms. Differences in inflammatory marker levels between MHO and the other three phenotypes were pooled as standardized mean differences (SMD) or differences of medians (DM) using a random-effects model. We included 91 studies reporting data on 435,007 individuals. The CRP levels were higher in MHO than in MHNO subjects (SMD = 0.63, 95% CI: 0.49, 0.76; DM = 0.83 mg/L, 95% CI: 0.56, 1.11). The CRP levels were higher in MHO than in MUNO subjects (SMD = 0.16, 95% CI: 0.05, 0.28; DM = 0.39 mg/L, 95% CI: 0.09, 0.69). The CRP levels were lower in MHO than in MUO individuals (SMD = −0.43, 95% CI: −0.54, −0.31; DM = −0.82 mg/L, 95% CI: −1.16, −0.48). The IL-6 levels in MHO were higher than in MHNO while lower than in MUO subjects. The TNF-α levels in MHO were higher than in MHNO individuals. This review provides evidence that CRP levels in MHO are higher than in MHNO and MUNO subjects but lower than in MUO individuals. Additionally, IL-6 levels in MHO are higher than in MHNO but lower than in MUO subjects, and TNF-α levels in MHO are higher than in MHNO individuals. PROSPERO number: CRD42021234948. •Levels of inflammatory markers in metabolically healthy obese (MHO): the first meta-analysis.•CRP levels in MHO are higher than in MHNO and MUNO but lower than in MUO subjects.•IL-6 levels in MHO are higher than in MHNO but lower than in MUO subjects.•TNF-α levels in MHO are higher than in MHNO subjects.
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ISSN:0939-4753
1590-3729
1590-3729
DOI:10.1016/j.numecd.2023.09.002