Bioinformatics analysis identifies BST1 as a potential therapeutic target linked to neutrophil extracellular traps in patients with acute liver failure

Acute on chronic liver failure (ACLF) is a critical condition with a high mortality rate; however, the underlying mechanisms driving its progression remain poorly understood. Neutrophil extracellular traps (NETs), a recently discovered mechanism of cell death, may play a significant role in this pro...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 24549 - 9
Main Authors:	Tao, Mengyu, Fu, Jiwei, Wu, Xiaoping
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.07.2025 Nature Publishing Group Nature Portfolio
Subjects:	692/4017 692/4020/4021 692/53 Acute liver failure Acute-On-Chronic Liver Failure - genetics Animals Antigens, CD - genetics Antigens, CD - metabolism Bioinformatics CD4 antigen Cell death Computational Biology - methods Connectivity Datasets DEGs Disease Extracellular Traps - genetics Extracellular Traps - metabolism Female Gelatinase B Gene expression Gene Expression Profiling Gene Ontology Gene Regulatory Networks GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Humanities and Social Sciences Humans Immune microenvironment Immunological memory Infiltration Isoantigens Laboratory animals Leukocytes (neutrophilic) Liver Liver diseases Liver failure Liver Failure, Acute - genetics Lymphocytes T Macrophages Male Medical prognosis Memory cells Mice Molecular modelling Monocytes Mortality multidisciplinary Neutrophil extracellular traps Neutrophils Neutrophils - metabolism Pathogens Peripheral blood Plasma cells Protein-arginine deiminase Receptors, Cell Surface Science Science (multidisciplinary) Therapeutic targets TLR2 protein TLR4 protein Toll-like receptors WGCNA Immune microenvironment Acute liver failure DEGs WGCNA Neutrophil extracellular traps
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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