Comprehensive Whole Genome Sequencing Dataset of Mycobacterium tuberculosis Strains Collected Across Italy

Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC), remains a major global health challenge. Whole genome sequencing (WGS) offers an invaluable tool for understanding the genetic diversity and drug resistance profiles of MTBC. This study provides a comprehensive WGS dataset o...

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Bibliographic Details
Published in:Scientific data Vol. 12; no. 1; pp. 624 - 8
Main Authors: Ghodousi, Arash, Cannas, Angela, Tagliani, Elisa, Batignani, Virginia, Bisognin, Francesco, Borroni, Emanuele, Butera, Ornella, Codecasa, Luigi Ruffo, Monte, Paola Dal, De Maio, Flavio, Delogu, Giovanni, Mattei, Giovanna, Matteo, Giulio, Messina, Francesco, Omrani, Maryam, Perilli, Cinzia, Sali, Michela, Sotgiu, Giovanni, Tadolini, Marina, Torri, Stefania, Vismara, Chiara, Girardi, Enrico, Cirillo, Daniela Maria
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 15.04.2025
Nature Publishing Group
Nature Portfolio
Subjects:
631/114/1314
692/699/255/1856
Collaboration
Data Descriptor
Datasets
Disease transmission
Drug resistance
Epidemiology
Evolution
Genetic diversity
Genome, Bacterial
Genomes
Global health
HIV
Human immunodeficiency virus
Humanities and Social Sciences
Humans
Infections
Infectious diseases
Italy - epidemiology
multidisciplinary
Mutation
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Public health
Regions
Science
Science (multidisciplinary)
Tuberculosis
Tuberculosis - epidemiology
Tuberculosis - microbiology
Whole Genome Sequencing
Italy
ISSN:2052-4463, 2052-4463
Online Access:Get full text
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Summary:Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC), remains a major global health challenge. Whole genome sequencing (WGS) offers an invaluable tool for understanding the genetic diversity and drug resistance profiles of MTBC. This study provides a comprehensive WGS dataset of 2,520 MTBC isolates collected from four Italian regions—Lombardy, Piedmont, Emilia-Romagna, and Lazio—between 2017 and 2020. The dataset includes genomic data along with associated metadata, such as geographic location and drug susceptibility profiles, providing a robust resource for studying TB epidemiology and transmission dynamics. This collection represents the largest publicly available MTBC WGS dataset from Italy and has been validated to ensure accuracy and completeness. By making this dataset accessible, we aim to support collaborative research, facilitate the exploration of MTBC evolution and drug resistance, and enhance TB surveillance efforts.
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ISSN:2052-4463
2052-4463
DOI:10.1038/s41597-025-04966-1