Targeted next-generation sequencing to diagnose drug-resistant tuberculosis: a systematic review and meta-analysis

Targeted next-generation sequencing (NGS) can rapidly and simultaneously detect mutations associated with resistance to tuberculosis drugs across multiple gene targets. The use of targeted NGS to diagnose drug-resistant tuberculosis, as described in publicly available data, has not been comprehensiv...

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Bibliographic Details
Published in:	The Lancet infectious diseases Vol. 24; no. 10; pp. 1162 - 1176
Main Authors:	Schwab, Tiana Carina, Perrig, Lisa, Göller, Pauline Carlotta, Guebely De la Hoz, Freddy Fernando, Lahousse, Adrien Philippe, Minder, Beatrice, Günther, Gunar, Efthimiou, Orestis, Omar, Shaheed Vally, Egger, Matthias, Fenner, Lukas
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.10.2024 Elsevier Limited
Subjects:	Accuracy Allergies Amikacin Antibiotics Antitubercular Agents - pharmacology Bayesian analysis Bias Bivariate analysis Capreomycin Clinical trials Drug resistance Drugs Ethambutol Fluoroquinolones Gene sequencing Genomes High-Throughput Nucleotide Sequencing - methods Humans Infections Infectious diseases Isoniazid Meta-analysis Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Next-generation sequencing Quality assessment Quality control R&D Research & development Rifampin Risk assessment Search engines Sensitivity analysis Sensitivity and Specificity Streptomycin Systematic review Target detection Technology assessment Tuberculosis Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology
ISSN:	1473-3099, 1474-4457, 1474-4457
Online Access:	Get full text
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