Mechanistic insights into synergistic effects using coupled PK-PD modeling

Develop a novel coupled PK-PD model and apply it to quantitatively evaluate the synergistic effects of Hydroxysafflor Yellow A (HSYA) combined with Calycosin (CA) in the treatment of ischemic stroke. A total of 6 rats were modelled for middle cerebral artery occlusion (MCAO). Plasma was collected fr...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 15631 - 14
Main Authors:	Sun, Jinzhou, Chen, Qianqian, Zhuang, Chumeng, Li, Xiaohong, Yu, Li, Jin, Weifeng
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.05.2025 Nature Publishing Group Nature Portfolio
Subjects:	631/114/2164 631/154/436/1729 Animals Anthraquinones - pharmacokinetics Anthraquinones - pharmacology Calycosin Caspase-9 Cerebral blood flow Chalcone - analogs & derivatives Coupled PK-PD Disease Models, Animal Drug interaction Drug Synergism Humanities and Social Sciences Hydroxysafflor yellow A Infarction, Middle Cerebral Artery - drug therapy Interleukin-1beta - blood Ischemia Isoflavones - pharmacokinetics Isoflavones - pharmacology Male Metabolic rate Models, Biological multidisciplinary Pharmacodynamics Quinones - pharmacokinetics Quinones - pharmacology Rats Rats, Sprague-Dawley Retention time Science Science (multidisciplinary) Stroke Synergistic effect Synergistic effects Hydroxysafflor yellow A Coupled PK-PD Synergistic effects Calycosin
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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