Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

Airway type 2 inflammation is usually corticosteroid sensitive, but the role of type 2 inflammation as a mechanism of asthma in patients receiving high-dose inhaled corticosteroids (ICSs) is uncertain. We sought to determine whether airway type 2 inflammation persists in patients treated with ICSs a...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 143; no. 1; pp. 104 - 113.e14
Main Authors:	Peters, Michael C., Kerr, Sheena, Dunican, Eleanor M., Woodruff, Prescott G., Fajt, Merritt L., Levy, Bruce D., Israel, Elliot, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Wenzel, Sally E., Fahy, John V.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2019 Elsevier Limited
Subjects:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adult Age Asthma Asthma - blood Asthma - drug therapy Asthma - immunology Biomarkers Biomarkers - blood Blood levels Body mass index Body weight Corticosteroids Cytokines Cytokines - blood Cytokines - immunology Eosinophils - immunology Eosinophils - metabolism Eosinophils - pathology Family medical history Female Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Health care Humans Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Immunomodulators Inflammation Inflammation - blood Inflammation - immunology Leukocyte Count Leukocytes (eosinophilic) Longitudinal Studies Male Middle Aged Patients Respiratory tract Severe asthma Sputum steroid resistance Th2 Cells - immunology Th2 Cells - metabolism type 2 inflammation Values steroid resistance Feno stT2-low T2GM biomarkers ROC SARP AUC CT RIN OLS ICS Severe asthma type 2 inflammation srT2-high BMI
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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