Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy

Metabolic homeostasis requires engagement of catabolic and anabolic pathways consuming nutrients that generate and consume energy and biomass. Our current understanding of cell homeostasis and metabolism, including how cells utilize nutrients, comes largely from tissue and cell models analyzed after...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 5850 - 16
Main Authors:	Habashy, Aliyah, Acree, Christopher, Kim, Keun-Young, Zahraei, Ali, Dufresne, Martin, Phan, Sebastien, Cutler, Melanie, Patterson, Emilee, Mulligan, Alexandra G., Burkewitz, Kristopher, Flynn, Charles Robert, Lantier, Louise, Deerinck, Thomas, McGuinness, Owen P., Spraggins, Jeffrey M., Ellisman, Mark H., Arrojo e Drigo, Rafael
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.07.2025 Nature Publishing Group Nature Portfolio
Subjects:	101/58 14 147/135 147/136 147/143 631/443/319/333 631/80/2373 Animals Biomass energy production Blood levels Carbon Isotopes - metabolism Catheters Cell culture Endoplasmic Reticulum - metabolism Fluctuations Fractionation Gas detectors Glucose Glucose - metabolism Glycogen - metabolism Hepatocytes Hepatocytes - metabolism Hepatocytes - ultrastructure Homeostasis Humanities and Social Sciences Humans Image processing Image segmentation Isotopes Learning algorithms Lipid Droplets - metabolism Lipids Liver Machine learning Male Metabolic flux Metabolism Metabolites Mice Microenvironments Microscopy Microscopy - methods Mitochondria - metabolism multidisciplinary Nutrients Organelles Oxidation Pattern formation Patterning Plasma Proteins Scanning electron microscopy Science Science (multidisciplinary) Spatial analysis Stable isotopes
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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