Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation

With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed CHIP. How these mutations result in increased risk for numerous age-related diseases remains poorly understood. We conduct a multiracial meta-analysis o...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 4678 - 14
Main Authors:	Kirmani, Sara, Huan, Tianxiao, Van Amburg, Joseph C., Joehanes, Roby, Uddin, Md Mesbah, Nguyen, Ngoc Quynh H., Yu, Bing, Brody, Jennifer A., Fornage, Myriam, Bressler, Jan, Sotoodehnia, Nona, Ong, David A., Puddu, Fabio, Floyd, James S., Ballantyne, Christie M., Psaty, Bruce M., Raffield, Laura M., Natarajan, Pradeep, Conneely, Karen N., Weinstock, Joshua S., Carson, April P., Lange, Leslie A., Ferrier, Kendra, Heard-Costa, Nancy L., Murabito, Joanne, Bick, Alexander G., Levy, Daniel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.05.2025 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/100 13/31 38/91 45/22 45/23 45/41 631/208/176/1988 631/208/457 631/250/232 631/443/592/75 631/443/7 Age Age related diseases Aged Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Blood cells Cardiovascular diseases Cardiovascular Diseases - genetics Cardiovascular Diseases - mortality Cell culture CpG Islands - genetics DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetics Epigenome - genetics Female Gene Expression Regulation Gene regulation Genome-Wide Association Study Health risks Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Humanities and Social Sciences Humans Male Middle Aged Molecular modelling multidisciplinary Mutation Risk Science Science (multidisciplinary) Stem cells Transcriptomics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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