Semi-automated evaluation of trabecular meshwork and schlemm canal imaged with OCT in children with normal eyes vs. primary congenital glaucoma

Maldevelopment of Schlemm canal (SC) and trabecular meshwork (TM) is proposed in the pathogenesis of primary congenital glaucoma (PCG). This study aims to evaluate a semi-automated segmentation algorithm of SC and TM in pediatric patients scanned using overhead-mounted optical coherence tomography (...

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Bibliographic Details
Published in:Scientific reports Vol. 15; no. 1; pp. 12671 - 6
Main Authors: Wang, Bo, Gregston, Alden P., Naithani, Rizul, Alvarez, Samuel, Sigireddi, Rohini R., Freedman, Sharon F.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 12.04.2025
Nature Publishing Group
Nature Portfolio
Subjects:
692/308/3187
692/308/575
Algorithms
Automation
Canals (anatomy)
Child
Child, Preschool
Children
Eye
Female
Glaucoma
Glaucoma - congenital
Glaucoma - diagnostic imaging
Glaucoma - pathology
Humanities and Social Sciences
Humans
Infant
Male
multidisciplinary
Pathogenesis
Pediatrics
Schlemm's Canal
Science
Science (multidisciplinary)
Segmentation
Tomography, Optical Coherence - methods
Trabecular Meshwork - diagnostic imaging
Trabecular Meshwork - pathology
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Maldevelopment of Schlemm canal (SC) and trabecular meshwork (TM) is proposed in the pathogenesis of primary congenital glaucoma (PCG). This study aims to evaluate a semi-automated segmentation algorithm of SC and TM in pediatric patients scanned using overhead-mounted optical coherence tomography (OCT). Twenty-four children (33 eyes: 17 PCG, 16 normal), with mean age 1.3 ± 1.08 years, had anterior segment OCT imaging. Manual segmentation of SC and TM on individual B-scans represented the gold standard and was compared to semi-automated segmentation of the same structures. Intraclass correlation (ICC) compared the manual and semi-automated algorithm for several parameters: SC area (0.940), circularity (0.742), and aspect ratio (0.861); and TM thickness (0.807). Comparing eyes with PCG vs. normal, we found: (1) decreased SC area (4084 ± 4553µm 2 vs. 7362 ± 3961µm 2 , p  = 0.008), (2) increased SC circularity (0.46 ± 0.15 vs. 0.36 ± 0.14, p  = 0.011, 3) increased TM thickness (152 ± 43 μm vs. 110 ± 27 μm, p  < 0.001) and 4) decreased SC aspect ratio (5.35 ± 2.51 vs. 7.06 ± 2.48, p  = 0.012) in eyes with PCG. Semi-automated segmentation permits assessment of differences in SC and TM morphology in normal vs. PCG eyes. Further work is necessary to understand how SC and TM differ in these patients as well as other forms of childhood glaucoma.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-96963-y