Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study

Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule inhibitor of the TRK kinases, had shown activity in preclinical models and in adults with tumours harbouring TRK fusions. This...

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Veröffentlicht in:	The lancet oncology Jg. 19; H. 5; S. 705 - 714
Hauptverfasser:	Laetsch, Theodore W, DuBois, Steven G, Mascarenhas, Leo, Turpin, Brian, Federman, Noah, Albert, Catherine M, Nagasubramanian, Ramamoorthy, Davis, Jessica L, Rudzinski, Erin, Feraco, Angela M, Tuch, Brian B, Ebata, Kevin T, Reynolds, Mark, Smith, Steven, Cruickshank, Scott, Cox, Michael C, Pappo, Alberto S, Hawkins, Douglas S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.05.2018 Elsevier Limited
Schlagworte:	Administration, Oral Adolescent Adolescents Age Age Factors Alanine Alanine transaminase Anthracycline Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Aspartate aminotransferase Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - genetics Cancer therapies Central nervous system Chemotherapy Child Child, Preschool Children Clinical trials Discoidin Domain Receptor 2 - antagonists & inhibitors Discoidin Domain Receptor 2 - genetics Drug Administration Schedule Female Fibrosarcoma Gene Fusion Humans Infant Infants Kinases Leukopenia Male Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - genetics Metastases Metastasis Nausea Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Neuroblastoma Neutrophils Oncology Papillary thyroid cancer Patients Pediatrics Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Pyrazoles - administration & dosage Pyrazoles - adverse effects Pyrimidines - administration & dosage Pyrimidines - adverse effects Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Receptor, trkA - antagonists & inhibitors Receptor, trkA - genetics Receptor, trkB - antagonists & inhibitors Receptor, trkB - genetics Safety Solid tumors Surgery Thyroid cancer Time Factors Toxicity Treatment Outcome Tumors United States Vomiting Young Adult United States
ISSN:	1470-2045, 1474-5488, 1474-5488
Online-Zugang:	Volltext
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