Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study aims to investigate correlations between the...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 12032 - 14
Main Authors:	Miclea, Andrei, Zurawski, Jonathan, Healy, Brian C., Saxena, Shrishti, Lokhande, Hrishikesh, Quattrucci, Molly, Chu, Renxin, Weiner, Howard L., Bakshi, Rohit, Chitnis, Tanuja
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.04.2025 Nature Publishing Group Nature Portfolio
Subjects:	692/617 692/699/375/1666 7 Tesla Adult Atrophy Autoimmune diseases Biomarkers Biomarkers - blood BLyS protein Cortical lesions Deep gray matter lesions Demyelination Female Gray Matter - diagnostic imaging Gray Matter - pathology Humanities and Social Sciences Humans Leptomeningeal enhancement Lesions Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Meninges Meninges - diagnostic imaging Meninges - pathology Middle Aged multidisciplinary Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology Pathogenesis Proteins Science Science (multidisciplinary) Serum proteins Substantia alba Substantia grisea Thalamus Biomarkers Cortical lesions Leptomeningeal enhancement Multiple sclerosis Deep gray matter lesions 7 Tesla
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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