Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study aims to investigate correlations between the...

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Bibliographic Details
Published in:Scientific reports Vol. 15; no. 1; pp. 12032 - 14
Main Authors: Miclea, Andrei, Zurawski, Jonathan, Healy, Brian C., Saxena, Shrishti, Lokhande, Hrishikesh, Quattrucci, Molly, Chu, Renxin, Weiner, Howard L., Bakshi, Rohit, Chitnis, Tanuja
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 08.04.2025
Nature Publishing Group
Nature Portfolio
Subjects:
692/617
692/699/375/1666
7 Tesla
Adult
Atrophy
Autoimmune diseases
Biomarkers
Biomarkers - blood
BLyS protein
Cortical lesions
Deep gray matter lesions
Demyelination
Female
Gray Matter - diagnostic imaging
Gray Matter - pathology
Humanities and Social Sciences
Humans
Leptomeningeal enhancement
Lesions
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Meninges
Meninges - diagnostic imaging
Meninges - pathology
Middle Aged
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Pathogenesis
Proteins
Science
Science (multidisciplinary)
Serum proteins
Substantia alba
Substantia grisea
Thalamus
Biomarkers
Cortical lesions
Leptomeningeal enhancement
Multiple sclerosis
Deep gray matter lesions
7 Tesla
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study aims to investigate correlations between the concentrations of 112 serum proteins and 7 Tesla MRI-defined measures of disease severity in patients with early MS. In this analysis, patients with CIS or MS having a 7 Tesla brain MRI and blood sample both within five years of MS diagnosis were included (n = 57). Correlational analysis was adjusted for sex, age, and disease duration. Correlation between serum proteins and MRI-defined cortical and thalamic gray matter lesions, leptomeningeal enhancement (presence and foci number), deep gray matter (DGM) structure volumes, whole brain parenchymal volume and total T2 white matter lesion volume was assessed. In this study, cortical lesions were associated with higher IL-15, TNF-alpha, and BAFF levels, and lower levels of FcRL2. Leptomeningeal enhancement was associated with higher levels of PLXNB3 and lower levels of nCDase and CNTN5. Higher IL-1B levels correlated with lower DGM volume while higher levels of CDH6, SIGLEC9, and HAGH correlated with higher DGM volume. These novel associations between serum immune proteins and 7 T MRI outcomes may have relevance as disease biomarkers in early stages of MS.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-95229-x