UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation

The accumulation of foamy macrophages is a pathological hallmark of demyelinating brain disorders. Perturbed metabolism and efflux of intracellular lipids underlie the development of a harmful foamy macrophage phenotype in these disorders, yet, the molecular mechanisms underlying this dysregulation...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 8077 - 18
Main Authors:	Loix, Melanie, Vanherle, Sam, Bolkaerts, Laura, Verberk, Sanne G. S., Punt, Mattijs, Wouters, Flore, Moonen, Brecht, Verhagen, Rob, Van Wouw, Suzanne A. E., Jongejan, Aldo, Distel, Ben, Elgersma, Ype, Haidar, Mansour, Zelcer, Noam, Hendriks, Jerome J. A., Bogie, Jeroen F. J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.08.2025 Nature Publishing Group Nature Portfolio
Subjects:	13/109 13/31 13/51 14/19 38/39 38/88 45/90 45/91 631/250/371 631/337/458/582 631/45/287/1197 631/45/612/1237 631/80/389/2023 64/60 82/80 96/21 ABCA1 protein Accumulation Animals ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism ATP-binding protein Bone marrow Brain Brain - metabolism Central nervous system Cholesterol Degradation Demyelination Disorders Efflux Enzymes Foam Cells - metabolism Gene expression Genotype & phenotype Humanities and Social Sciences Humans Lipid metabolism Lipids Macrophages Male Metabolism Metabolites Mice Mice, Inbred C57BL Mice, Knockout Molecular modelling multidisciplinary Myelin Myelin Sheath - metabolism Myelination Nuclear transport Phenotypes Proteasome Endopeptidase Complex - metabolism Proteasomes Proteins Proteolysis Remyelination - physiology Science Science (multidisciplinary) Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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